Review: The Emerging Role of Neutrophil Extracellular Traps in Sepsis and Sepsis-Associated Thrombosis

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Platelet Gene Expression and Function in COVID-19 Patients

(2020) Bhanu Kanth Manne et al.   BLOOD

miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis

(2020) Ana B. Arroyo et al.   HAEMATOLOGICA

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

(2019) José Perdomo et al.   Nature Communications

A Novel Assay for Neutrophil Extracellular Traps (NETs) Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients

(2019) Simon T Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice

(2019) Yanyan Yan et al.   Aging-US

Quantification of NETs formation in neutrophil and its correlation with the severity of sepsis and organ dysfunction

(2019) Sanni Kumar et al.   CLINICA CHIMICA ACTA

Heparin improves alveolarization and vascular development in hyperoxia-induced bronchopulmonary dysplasia by inhibiting neutrophil extracellular traps

(2019) Yuanyuan Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation

(2019) Binita Shrestha et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G

(2018) Eduardo J. Folco et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis

(2018) Bas G.J. Surewaard et al.   Cell Host & Microbe

Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial InjuryNovelty and Significance

(2018) Grégory Franck et al.   CIRCULATION RESEARCH

Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia

(2018) Yingjian Liang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke

(2018) Celina Ducroux et al.   STROKE

Neutrophils, NETs, and immunothrombosis

(2018) Steven P. Grover et al.   BLOOD

Platelet TLR4 at the crossroads of thrombosis and the innate immune response

(2018) Mirta Schattner   JOURNAL OF LEUKOCYTE BIOLOGY

Platelet biology and functions: new concepts and clinical perspectives

(2018) Paola E. J. van der Meijden et al.   Nature Reviews Cardiology

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia

(2017) Andrea T. Obi et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics

(2017) Wei Gao et al.   Frontiers in Physiology

Neutrophil Extracellular Traps Promote AngiogenesisHighlights

(2016) Lulwah Aldabbous et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NETs Activate Pulmonary Arterial Endothelial Cells

(2016) Marlene Rabinovitch   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Coagulation abnormalities identified by thromboelastometry in patients with severe sepsis

(2016) Barbara Adamik et al.   BLOOD COAGULATION & FIBRINOLYSIS

The membrane attack complex as an inflammatory trigger

(2016) B. Paul Morgan   IMMUNOBIOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

New Aspects of the Biology of Neutrophil Extracellular Traps

(2016) D. Dąbrowska et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Sepsis: pathophysiology and clinical management

(2016) Jeffrey E Gotts et al.   BMJ-British Medical Journal

Sepsis: pathophysiology and clinical management

(2016) Jeffrey E Gotts et al.   BMJ-British Medical Journal

NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways

(2016) Joshua Yuen et al.   Frontiers in Immunology

Platelets: New Bricks in the Building of Neutrophil Extracellular Traps

(2016) Agostina Carestia et al.   Frontiers in Immunology

Circulating Level of Neutrophil Extracellular Traps Is Not a Useful Biomarker for Assessing Disease Activity in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

(2016) Huan Wang et al.   PLoS One

Synergistic Action of Staphylococcus aureus α-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis

(2015) Michael E. Powers et al.   Cell Host & Microbe

Neutrophil extracellular traps can activate alternative complement pathways

(2015) H. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Platelets in inflammation and infection

(2015) Craig N. Jenne et al.   PLATELETS

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

(2014) Carmelo Carmona-Rivera et al.   ANNALS OF THE RHEUMATIC DISEASES

Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice

(2014) S. F. de Stoppelaar et al.   BLOOD

Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment

(2014) Mary Sandquist et al.   Expert Review of Clinical Immunology

Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes via FcγRIIIB and Mac-1

(2014) Martina Behnen et al.   JOURNAL OF IMMUNOLOGY

Neutrophil extracellular traps promote differentiation and function of fibroblasts

(2014) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

Neutrophils as new conductors of vascular homeostasis

(2014) D. M. Smadja   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients

(2014) Tomoya Hirose et al.   PLoS One

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

(2013) Matthew D. Neal et al.   PLoS One

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice

(2012) G. M. Thomas et al.   BLOOD

Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation

(2012) R. Darbousset et al.   BLOOD

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Complement, interferon and lupus

(2012) Keith B Elkon et al.   CURRENT OPINION IN IMMUNOLOGY

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction

(2012) Xiaofei Li et al.   THROMBOSIS AND HAEMOSTASIS

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

(2011) Alexander A. Chumanevich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Porphyromonas gingivalis Participates in Pathogenesis of Human Abdominal Aortic Aneurysm by Neutrophil Activation. Proof of Concept in Rats

(2011) Sandrine Delbosc et al.   PLoS One

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Microvascular thrombosis and multiple organ dysfunction syndrome

(2010) Satoshi Gando   CRITICAL CARE MEDICINE

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Valsartan preconditioning protects against myocardial ischemia–reperfusion injury through TLR4/NF-κB signaling pathway

(2009) Jian Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo

(2008) Mohan R. Dasu et al.   ATHEROSCLEROSIS