Dysregulated Immunity and Immunotherapy after Sepsis

Immunological Endotyping of Chronic Critical Illness After Severe Sepsis

(2021) Brittany P. Fenner et al.   Frontiers in Medicine

Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) after Polytrauma: A Rare Syndrome with Major Consequences

(2020) Lillian Hesselink et al.   Journal of Clinical Medicine

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

(2020) Andrew M. K. Law et al.   Cells

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival

(2020) Robert T. Mankowski et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes

(2020) Michael C. Cox et al.   AMERICAN JOURNAL OF SURGERY

The Hematopoietic Stem/Progenitor Cell Response to Hemorrhage, Injury and Sepsis

(2020) Lauren S. Kelly et al.   SHOCK

The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs*

(2019) Anna K. Gardner et al.   CRITICAL CARE MEDICINE

Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes

(2019) Scott C. Brakenridge et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Current Epidemiology of Surgical Sepsis

(2019) Scott C. Brakenridge et al.   ANNALS OF SURGERY

Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis

(2019) Jolie Barter et al.   MOLECULAR NEUROBIOLOGY

Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series

(2019) Didier Payen et al.   BMC INFECTIOUS DISEASES

Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness

(2019) Russell B. Hawkins et al.   SURGERY

Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult

(2018) Tyler J. Loftus et al.   CURRENT OPINION IN HEMATOLOGY

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients

(2018) Julie A. Stortz et al.   Journal of Trauma and Acute Care Surgery

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Chronic Critical Illness: Application of What We Know

(2018) Martin D. Rosenthal et al.   NUTRITION IN CLINICAL PRACTICE

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders

(2018) Anna Picca et al.   REJUVENATION RESEARCH

Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis

(2018) Julie A. Stortz et al.   SHOCK

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients

(2018) Julie A. Stortz et al.   Journal of Trauma and Acute Care Surgery

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

(2018) Hiroyuki Horiguchi et al.   Frontiers in Immunology

Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome

(2018) Russell B. Hawkins et al.   Frontiers in Immunology

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014

(2017) Chanu Rhee et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases

(2017) Kyunghee Byun et al.   PHARMACOLOGY & THERAPEUTICS

Exosomes, DAMPs and miRNA: Features of Stress Physiology and Immune Homeostasis

(2017) Monika Fleshner et al.   TRENDS IN IMMUNOLOGY

Elevated Levels of Plasma Mitochondrial DNA Are Associated with Clinical Outcome in Intra-Abdominal Infections Caused by Severe Trauma

(2017) Qiongyuan Hu et al.   Surgical Infections

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

(2016) Matthew J. Delano et al.   JOURNAL OF CLINICAL INVESTIGATION

Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1

(2016) Andriani C. Patera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The long-term burden of severe sepsis and septic shock

(2016) Faheem W. Guirgis et al.   Journal of Trauma and Acute Care Surgery

Innate cell communication kick-starts pathogen-specific immunity

(2016) Amariliz Rivera et al.   NATURE IMMUNOLOGY

Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression

(2016) Naeem K. Patil et al.   PHARMACOLOGICAL RESEARCH

Plasma Nuclear and Mitochondrial DNA Levels, and Markers of Inflammation, Shock, and Organ Damage in Patients with Septic Shock

(2016) Kim Timmermans et al.   SHOCK

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

The long-term burden of severe sepsis and septic shock

(2016) Faheem W. Guirgis et al.   Journal of Trauma and Acute Care Surgery

Timing of onset and burden of persistent critical illness in Australia and New Zealand: a retrospective, population-based, observational study

(2016) Theodore J Iwashyna et al.   Lancet Respiratory Medicine

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

Immunesenescence and inflammaging: A contributory factor in the poor outcome of the geriatric trauma patient

(2015) Jon Hazeldine et al.   AGEING RESEARCH REVIEWS

DAMPs activating innate immune responses in sepsis

(2015) Jung-Woo Kang et al.   AGEING RESEARCH REVIEWS

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

(2015) Lieping Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer

(2015) Kevin C. Conlon et al.   JOURNAL OF CLINICAL ONCOLOGY

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged

(2015) Dina C. Nacionales et al.   JOURNAL OF IMMUNOLOGY

STAT5 phosphorylation in T cell subsets from septic patients in response to recombinant human interleukin-7: a pilot study

(2015) Julie Demaret et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Soluble RAGE and the RAGE Ligands HMGB1 and S100A12 in Critical Illness

(2015) Catherine Ingels et al.   SHOCK

Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model

(2015) Xiao Yao et al.   PLoS One

Importance of Toll-like Receptor 2 in Mitochondrial Dysfunction during Polymicrobial Sepsis

(2014) Yu Gong et al.   ANESTHESIOLOGY

Circulating Immature Granulocytes With T-Cell Killing Functions Predict Sepsis Deterioration*

(2014) Estelle Guérin et al.   CRITICAL CARE MEDICINE

Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study

(2014) Mitchell M. Levy et al.   INTENSIVE CARE MEDICINE

A high frequency of MDSCs in sepsis patients, with the granulocytic subtype dominating in gram-positive cases

(2014) Helena Janols et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Computer versus paper system for recognition and management of sepsis in surgical intensive care

(2014) Chasen A. Croft et al.   Journal of Trauma and Acute Care Surgery

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

Parallels between Cancer and Infectious Disease

(2014) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reactivation of Multiple Viruses in Patients with Sepsis

(2014) Andrew H. Walton et al.   PLoS One

One-Year Trajectories of Care and Resource Utilization for Recipients of Prolonged Mechanical Ventilation

(2013) Mark Unroe   ANNALS OF INTERNAL MEDICINE

Development of a Genomic Metric That Can Be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients*

(2013) Alex G. Cuenca et al.   CRITICAL CARE MEDICINE

Acute Skeletal Muscle Wasting in Critical Illness

(2013) Zudin A. Puthucheary et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

S100A12 and Soluble Receptor for Advanced Glycation End Products Levels During Human Severe Sepsis

(2013) Ahmed Achouiti et al.   SHOCK

Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome

(2012) Monika Fleshner   BRAIN BEHAVIOR AND IMMUNITY

The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure

(2012) Thomas Maslanik et al.   BRAIN BEHAVIOR AND IMMUNITY

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

(2012) Lara M Kingeter et al.   Cellular & Molecular Immunology

Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study

(2012) Y. Lévy et al.   CLINICAL INFECTIOUS DISEASES

Decreased T-Cell Repertoire Diversity in Sepsis

(2012) Fabienne Venet et al.   CRITICAL CARE MEDICINE

ATP Hydrolysis Enhances RNA Recognition and Antiviral Signal Transduction by the Innate Immune Sensor, Laboratory of Genetics and Physiology 2 (LGP2)

(2012) Annie M. Bruns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-7 Restores Lymphocyte Functions in Septic Patients

(2012) F. Venet et al.   JOURNAL OF IMMUNOLOGY

Interleukin-7 Ameliorates Immune Dysfunction and Improves Survival in a 2-Hit Model of Fungal Sepsis

(2012) Jacqueline Unsinger et al.   JOURNAL OF INFECTIOUS DISEASES

Population Burden of Long-Term Survivorship After Severe Sepsis in Older Americans

(2012) Theodore J. Iwashyna et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia

(2012) S L Poe et al.   Mucosal Immunology

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unknown

(2011) Alex Cuenca et al.   MOLECULAR MEDICINE

The Inflammasomes: Molecular Effectors of Host Resistance Against Bacterial, Viral, Parasitic, and Fungal Infections

(2011) Alexander Skeldon et al.   Frontiers in Microbiology

Computer Protocol Facilitates Evidence-Based Care of Sepsis in the Surgical Intensive Care Unit

(2011) Bruce A. McKinley et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

The Epidemiology of Sepsis in General Surgery Patients

(2011) Laura J. Moore et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Long-term mortality and quality of life in sepsis: A systematic review*

(2010) Bradford D. Winters et al.   CRITICAL CARE MEDICINE

The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity

(2010) Je-In Youn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oxidative stress and endothelial dysfunction during sepsis

(2010) Olivier Huet   Frontiers in Bioscience-Landmark

Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock

(2010) Caroline Landelle et al.   INTENSIVE CARE MEDICINE

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function

(2010) Leif E. Sander et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

(2010) J. Unsinger et al.   JOURNAL OF IMMUNOLOGY

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

(2010) P. Brahmamdam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

A Ribonucleotide Reductase Inhibitor Reverses Burn-Induced Inflammatory Defects

(2010) Greg Noel et al.   SHOCK

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expectations and outcomes of prolonged mechanical ventilation*

(2009) Christopher E. Cox et al.   CRITICAL CARE MEDICINE

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

(2008) Claude Sportès et al.   JOURNAL OF EXPERIMENTAL MEDICINE