Targeting Neutrophils in Sepsis: From Mechanism to Translation

Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis

(2021) Amir Boufenzer et al.   Cellular & Molecular Immunology

P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation

(2020) Alexandre Mansour et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular CIRP and TREM‐1 axis promotes ICAM‐1‐Rho‐mediated NETosis in sepsis

(2020) Atsushi Murao et al.   FASEB JOURNAL

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

(2020) Xuemei Xie et al.   NATURE IMMUNOLOGY

Neutralizing the pathological effects of extracellular histones with small polyanions

(2020) Connor H. O’ Meara et al.   Nature Communications

Reactive Oxygen Species Interact With NLRP3 Inflammasomes and Are Involved in the Inflammation of Sepsis: From Mechanism to Treatment of Progression

(2020) Shuai Zhao et al.   Frontiers in Physiology

Immune Checkpoint Inhibition in Sepsis

(2019) Richard S. Hotchkiss et al.   CRITICAL CARE MEDICINE

Understanding how Fc-modification transforms a pathogenic HIT-like monoclonal antibody into a novel treatment for sepsis

(2019) Kandace Gollomp et al.   BLOOD

Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke

(2019) Can Yang Zhang et al.   Science Advances

Current gaps in sepsis immunology: new opportunities for translational research

(2019) Ignacio Rubio et al.   LANCET INFECTIOUS DISEASES

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G

(2018) Eduardo J. Folco et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multicentric Standardized Flow Cytometry Routine Assessment of Patients With Sepsis to Predict Clinical Worsening

(2018) Thomas Daix et al.   CHEST

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

PAD4 Deficiency Leads to Decreased Organ Dysfunction and Improved Survival in a Dual Insult Model of Hemorrhagic Shock and Sepsis

(2018) Bethany M. Biron et al.   JOURNAL OF IMMUNOLOGY

Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs)

(2018) Rihito Kanamaru et al.   Scientific Reports

Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay

(2018) Felix Ellett et al.   Nature Biomedical Engineering

Kinase activity is impaired in neutrophils of sepsis patients

(2018) Arie J. Hoogendijk et al.   HAEMATOLOGICA

Immature Neutrophils Released in Acute Inflammation Exhibit Efficient Migration despite Incomplete Segmentation of the Nucleus

(2018) Erinke van Grinsven et al.   JOURNAL OF IMMUNOLOGY

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

(2017) Andrew Rhodes et al.   INTENSIVE CARE MEDICINE

Neutrophil dysregulation during sepsis: an overview and update

(2017) Xiao-Fei Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Spleen-derived IFN-γ induces generation of PD-L1 + -suppressive neutrophils during endotoxemia

(2017) Jeroen D. Langereis et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Visualizing the function and fate of neutrophils in sterile injury and repair

(2017) Jing Wang et al.   SCIENCE

AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol

(2017) Damon P Eisen et al.   BMJ Open

Wip1 Deficiency Promotes Neutrophil Recruitment to the Infection Site and Improves Sepsis Outcome

(2017) Xiao-Fei Shen et al.   Frontiers in Immunology

Phosphatase Wip1 in Immunity: An Overview and Update

(2017) Xiao-Fei Shen et al.   Frontiers in Immunology

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

P2Y12Receptor Modulates Sepsis-Induced InflammationSignificance

(2016) Elisabetta Liverani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophil heterogeneity: implications for homeostasis and pathogenesis

(2016) C. Silvestre-Roig et al.   BLOOD

Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives

(2016) Julio Lahoz-Beneytez et al.   BLOOD

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model

(2016) Bethany M. Biron et al.   Journal of Innate Immunity

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

Mechanical Ventilation Induces Neutrophil Extracellular Trap Formation

(2015) Christopher Yildiz et al.   ANESTHESIOLOGY

ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia

(2015) A. Woodfin et al.   BLOOD

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Prehospital Aspirin Use Is Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically Ill Patients

(2015) Wei Chen et al.   CRITICAL CARE MEDICINE

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo

(2015) Bartomeu Colom et al.   IMMUNITY

Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2

(2015) Sung Kyun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Acute-Phase Deaths from Murine Polymicrobial Sepsis Are Characterized by Innate Immune Suppression Rather Than Exhaustion

(2015) Evan L. Chiswick et al.   JOURNAL OF IMMUNOLOGY

Marked alterations of neutrophil functions during sepsis-induced immunosuppression

(2015) Julie Demaret et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis

(2015) Safiah H. C. Mai et al.   SHOCK

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

(2015) Adam P. Levine et al.   PLoS One

Neutrophil Extracellular Traps in Sepsis

(2014) Gabriela Camicia et al.   SHOCK

Citrullinated histone H3: A novel target for the treatment of sepsis

(2014) Yongqing Li et al.   SURGERY

Hypoxia-inducible factor 2  regulates key neutrophil functions in humans, mice, and zebrafish

(2013) A. A. R. Thompson et al.   BLOOD

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Innate Immune Functions of Immature Neutrophils in Patients With Sepsis and Severe Systemic Inflammatory Response Syndrome*

(2013) Geneviève Drifte et al.   CRITICAL CARE MEDICINE

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

Depletion of blood neutrophils from patients with sepsis: treatment for the future?

(2013) Sion M. Lewis et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

IFN-γ-Stimulated Neutrophils Suppress Lymphocyte Proliferation through Expression of PD-L1

(2013) Stan de Kleijn et al.   PLoS One

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1

(2012) G. Liu et al.   BLOOD

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis

(2012) Damon P. Eisen et al.   CRITICAL CARE MEDICINE

The function of neutrophils in sepsis

(2012) Melissa A. Kovach et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Transcriptome Kinetics of Circulating Neutrophils during Human Experimental Endotoxemia

(2012) Stan de Kleijn et al.   PLoS One

Generation of Nitric Oxide and Reactive Oxygen Species by Neutrophils and Monocytes From Septic Patients and Association With Outcomes

(2012) Sidnéia Sousa Santos et al.   SHOCK

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands

(2011) A. Kohler et al.   BLOOD

C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients

(2011) A. C. Morris et al.   BLOOD

Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization

(2011) Meenu Mishra et al.   CELLULAR MICROBIOLOGY

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Mobilization from the Bone Marrow during Polymicrobial Sepsis Is Dependent on CXCL12 Signaling

(2011) M. J. Delano et al.   JOURNAL OF IMMUNOLOGY

Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20

(2011) Yanbao Xiong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phosphoinositide-3 Kinase γ Activity Contributes to Sepsis and Organ Damage by Altering Neutrophil Recruitment

(2010) Erica L. Martin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Essential Role of CCR2 in Neutrophil Tissue Infiltration and Multiple Organ Dysfunction in Sepsis

(2010) Fabricio O. Souto et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome

(2010) Mark W. Hall et al.   INTENSIVE CARE MEDICINE

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection

(2010) M. J. Delano et al.   JOURNAL OF IMMUNOLOGY

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections

(2009) A. A. Navarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor- 

(2008) R. C. Reddy et al.   BLOOD

Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression

(2008) D. D. Danikas et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease

(2008) J. Cooley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IMMATURE CIRCULATING NEUTROPHILS IN SEPSIS HAVE IMPAIRED PHAGOCYTOSIS AND CALCIUM SIGNALING

(2008) Ravi Taneja et al.   SHOCK