Neutrophil dysregulation during sepsis: an overview and update

DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC

(2016) Patricia C. Liaw et al.   BLOOD REVIEWS

Role of cellular events in the pathophysiology of sepsis

(2016) Chandra Bhan et al.   INFLAMMATION RESEARCH

Assessment of Clinical Criteria for Sepsis

(2016) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

(2016) Matthew J. Delano et al.   JOURNAL OF CLINICAL INVESTIGATION

Is plasma neutrophil gelatinase-associated lipocalin a predictive biomarker for acute kidney injury in sepsis patients? A systematic review and meta-analysis

(2016) Sollip Kim et al.   JOURNAL OF CRITICAL CARE

CD64 index on neutrophils can diagnose sepsis and predict 30-day survival in subjects after ventilator-associated pneumonia

(2016) Igor Muzlovic et al.   Journal of Infection in Developing Countries

Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious

(2016) Fabiane Sônego et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

Up-regulation of Programmed Cell Death 1 Ligand 1 on Neutrophils May Be Involved in Sepsis-induced Immunosuppression

(2015) Jia-Feng Wang et al.   ANESTHESIOLOGY

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

sTREM-1 predicts intensive care unit and 28-day mortality in cancer patients with severe sepsis and septic shock

(2015) Cecilia Gómez Ravetti et al.   JOURNAL OF CRITICAL CARE

Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2

(2015) Sung Kyun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sepsis: An update in management

(2015) Benjamin T. Galen et al.   Journal of Hospital Medicine

Identification of a Novel Splice Variant Isoform of TREM-1 in Human Neutrophil Granules

(2015) Sankar Baruah et al.   JOURNAL OF IMMUNOLOGY

Insights into the Apoptotic Death of Immune Cells in Sepsis

(2015) Ying-yi Luan et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Marked alterations of neutrophil functions during sepsis-induced immunosuppression

(2015) Julie Demaret et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil extracellular traps contribute to the intestine damage in endotoxemic rats

(2015) Xin Gao et al.   JOURNAL OF SURGICAL RESEARCH

Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis

(2015) Kirsi-Maija Kaukonen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proinflammatory role of neutrophil extracellular traps in abdominal sepsis

(2014) Lingtao Luo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

(2014) Kirsi-Maija Kaukonen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Strategies to improve drug development for sepsis

(2014) Mitchell P. Fink et al.   NATURE REVIEWS DRUG DISCOVERY

Combining Immature and Total Neutrophil Counts to Predict Early Onset Sepsis in Term and Late Preterm Newborns

(2014) Thomas B. Newman et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Spontaneous Neutrophil Migration Patterns during Sepsis after Major Burns

(2014) Caroline N. Jones et al.   PLoS One

In Vivo Characterization of Neutrophil Extracellular Traps in Various Organs of a Murine Sepsis Model

(2014) Koji Tanaka et al.   PLoS One

Revisiting the white blood cell count: immature granulocytes count as a diagnostic marker to discriminate between SIRS and sepsis - a prospective, observational study

(2013) Axel Nierhaus et al.   BMC IMMUNOLOGY

Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Circulating soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as diagnostic and prognostic marker in neonatal sepsis

(2013) Amira A.M. Adly et al.   CYTOKINE

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

Genome-wide expression profiling in pediatric septic shock

(2013) Hector R. Wong   PEDIATRIC RESEARCH

Combination Biomarkers to Diagnose Sepsis in the Critically Ill Patient

(2012) Sébastien Gibot et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis

(2012) Tobias A. Fuchs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study

(2012) Longxiang Su et al.   BMC INFECTIOUS DISEASES

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome*

(2012) Silvia C. Trevelin et al.   CRITICAL CARE MEDICINE

The function of neutrophils in sepsis

(2012) Melissa A. Kovach et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Neutrophil CD64 expression as a biomarker in the early diagnosis of bacterial infection: a meta-analysis

(2012) Shan Li et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Novel Predictors of Sepsis Outperform the American Burn Association Sepsis Criteria in the Burn Intensive Care Unit Patient

(2012) Elizabeth A. Mann-Salinas et al.   Journal of Burn Care & Research

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study

(2012) Mitchell M Levy et al.   LANCET INFECTIOUS DISEASES

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis

(2012) Konstantinos Kambas et al.   PLoS One

Measurement of Plasma STREM-1 in Patients With Severe Sepsis Receiving Early Goal-Directed Therapy and Evaluation of Its Usefulness

(2012) Su Jin Jeong et al.   SHOCK

Delta Neutrophil Index

(2012) Yoonmi Seok et al.   SHOCK

Myeloid nuclear differentiation antigen, neutrophil apoptosis and sepsis

(2012) Eric Milot et al.   Frontiers in Immunology

The Pathogenesis of Sepsis

(2011) Deborah J. Stearns-Kurosawa et al.   Annual Review of Pathology-Mechanisms of Disease

Delta neutrophil index as an early marker of disease severity in critically ill patients with sepsis

(2011) Byung Hoon Park et al.   BMC INFECTIOUS DISEASES

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization

(2011) Meenu Mishra et al.   CELLULAR MICROBIOLOGY

Bacterial lipoprotein-induced tolerance is reversed by overexpression of IRAK-1

(2011) Chong Hui Li et al.   IMMUNOLOGY AND CELL BIOLOGY

LOX-1 Deletion Improves Neutrophil Responses, Enhances Bacterial Clearance, and Reduces Lung Injury in a Murine Polymicrobial Sepsis Model

(2011) Zhuang Wu et al.   INFECTION AND IMMUNITY

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Mobilization from the Bone Marrow during Polymicrobial Sepsis Is Dependent on CXCL12 Signaling

(2011) M. J. Delano et al.   JOURNAL OF IMMUNOLOGY

Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20

(2011) Yanbao Xiong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Protease inhibitors decrease IgG shedding from Staphylococcus aureus, increasing complement activation and phagocytosis efficiency

(2011) M. F. Fernandez Falcon et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Divergent Role OF Heme Oxygenase Inhibition in the Pathogenesis of Sepsis

(2011) Andressa Freitas et al.   SHOCK

Nonhematopoietic Toll-Like Receptor 2 Contributes to Neutrophil and Cardiac Function Impairment During Polymicrobial Sepsis

(2011) Lin Zou et al.   SHOCK

Hydrogen Sulfide Improves Neutrophil Migration and Survival in Sepsis via K+ATPChannel Activation

(2010) Fernando Spiller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phosphoinositide-3 Kinase γ Activity Contributes to Sepsis and Organ Damage by Altering Neutrophil Recruitment

(2010) Erica L. Martin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of Neutrophil Migration by Hemopexin Leads to Increased Mortality Due to Sepsis in Mice

(2010) Fernando Spiller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Essential Role of CCR2 in Neutrophil Tissue Infiltration and Multiple Organ Dysfunction in Sepsis

(2010) Fabricio O. Souto et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil gelatinase-associated lipocalin

(2010) Michael Haase et al.   Current Opinion in Critical Care

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection

(2010) M. J. Delano et al.   JOURNAL OF IMMUNOLOGY

Neutrophil CD64 expression as marker of bacterial infection: A systematic review and meta-analysis

(2010) Joan Cid et al.   JOURNAL OF INFECTION

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Interleukin-33 safeguards neutrophils in sepsis

(2010) Thierry Roger et al.   NATURE MEDICINE

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

(2010) Jose C Alves-Filho et al.   NATURE MEDICINE

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NEUTROPHIL PARALYSIS IN SEPSIS

(2010) José C. Alves-Filho et al.   SHOCK

Inhibition of Guanylyl Cyclase Restores Neutrophil Migration and Maintains Bactericidal Activity Increasing Survival in Sepsis

(2010) Heitor A. Paula-Neto et al.   SHOCK

Macroscopic Postmortem Findings in 235 Surgical Intensive Care Patients with Sepsis

(2009) Christian Torgersen et al.   ANESTHESIA AND ANALGESIA

Neutrophil CD64: a diagnostic marker for infection and sepsis

(2009) Johannes J.M.L. Hoffmann   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Effects of sepsis on neutrophil chemotaxis

(2009) Raju C Reddy et al.   CURRENT OPINION IN HEMATOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

(2009) J. C. Alves-Filho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Short-Term Heat Exposure Inhibits Inflammation by Abrogating Recruitment of and Nuclear Factor-κB Activation in Neutrophils Exposed to Chemotactic Cytokines

(2008) Mira Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor- 

(2008) R. C. Reddy et al.   BLOOD

IMMATURE CIRCULATING NEUTROPHILS IN SEPSIS HAVE IMPAIRED PHAGOCYTOSIS AND CALCIUM SIGNALING

(2008) Ravi Taneja et al.   SHOCK

Nitric Oxide Regulates Neutrophil Migration through Microparticle Formation

(2007) Sarah Nolan et al.   AMERICAN JOURNAL OF PATHOLOGY