The effects of sepsis on endothelium and clinical implications

Poldip2 Deficiency Protects Against Lung Edema and Vascular Inflammation in a Model of Acute Respiratory Distress Syndrome

(2019) Steven J Forrester et al.   CLINICAL SCIENCE

Sepsis - Whatʼs new in 2019?

(2019) Mark E. Nunnally et al.   Current Opinion in Anesthesiology

A Peptide Inhibitor of NADPH Oxidase (NOX2) Activation Markedly Decreases Mouse Lung Injury and Mortality Following Administration of Lipopolysaccharide (LPS)

(2019) Aron B. Fisher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inter-α-inhibitor Ameliorates Endothelial Inflammation in Sepsis

(2019) Vandy P. Stober et al.   LUNG

Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization

(2019) Renyikun Yuan et al.   PHARMACOLOGICAL RESEARCH

Advance in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation

(2019) Toshiaki Iba et al.   Journal of Clinical Medicine

Toll‐like receptor 4: A promising therapeutic target for pneumonia caused by Gram‐negative bacteria

(2019) Junying Ding et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sox17 is required for endothelial regeneration following inflammation-induced vascular injury

(2019) Menglin Liu et al.   Nature Communications

Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial Hyperpermeability via the Axl/NF-κB Signaling Pathway

(2019) Jingjing Ni et al.   Frontiers in Pharmacology

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure

(2019) Alpha A. Fowler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Angiopoietin 2 Levels in the Risk Stratification and Mortality Outcome Prediction of Sepsis-Associated Coagulopathy

(2018) Stephen Statz et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammation

(2018) Liang Zhong et al.   FASEB JOURNAL

Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain

(2018) Marina S. Hernandes et al.   Journal of Neuroinflammation

Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia

(2018) Ranran Li et al.   PLoS One

Targeting β1-integrin inhibits vascular leakage in endotoxemia

(2018) Laura Hakanpaa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Activation: The Ang/Tie Axis in Sepsis

(2018) Aleksandra Leligdowicz et al.   Frontiers in Immunology

Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis

(2018) Yan He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Astragaloside IV improves vascular endothelial dysfunction by inhibiting the TLR4/NF-κB signaling pathway

(2018) Bin Leng et al.   LIFE SCIENCES

MiR-130b attenuates vascular inflammation via negatively regulating tumor progression locus 2 (Tpl2) expression

(2017) Peng Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

What is the Preferred Resuscitation Fluid for Patients with Severe Sepsis and Septic Shock?

(2017) Michael E. Winters et al.   JOURNAL OF EMERGENCY MEDICINE

Human resistin protects against endotoxic shock by blocking LPS–TLR4 interaction

(2017) Jessica C. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway

(2017) Hongwei Gao et al.   Cell Death & Disease

The use of the soluble adhesion molecules sE-selectin, sICAM-1, sVCAM-1, sPECAM-1 and their ligands CD11a and CD49d as diagnostic and prognostic biomarkers in septic and critically ill non-septic ICU patients

(2016) Anders G. Kjaergaard et al.   APMIS

MicroRNA-150 Suppression of Angiopoetin-2 Generation and Signaling Is Crucial for Resolving Vascular InjurySignificance

(2016) Charu Rajput et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LncRNA-HOTAIR promotes TNF-α production in cardiomyocytes of LPS-induced sepsis mice by activating NF-κB pathway

(2016) Hongwei Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Plasma syndecan-1 levels identify a cohort of patients with severe sepsis at high risk for intubation after large-volume intravenous fluid resuscitation

(2016) Michael A. Puskarich et al.   JOURNAL OF CRITICAL CARE

MicroRNA Regulation of Endothelial Junction Proteins and Clinical Consequence

(2016) Yugang Zhuang et al.   MEDIATORS OF INFLAMMATION

Circulating Endothelial Cells and Endothelial Progenitor Cells in Pediatric Sepsis

(2016) Asmaa Mohamad Zahran et al.   PEDIATRIC EMERGENCY CARE

Amelioration of sepsis by TIE2 activation–induced vascular protection

(2016) Sangyeul Han et al.   Science Translational Medicine

The Endothelium in Sepsis

(2016) Can Ince et al.   SHOCK

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension

(2016) Surawee Chuaiphichai et al.   VASCULAR PHARMACOLOGY

Regulatory role of microRNA-30b and plasminogen activator inhibitor-1 in the pathogenesis of cognitive impairment

(2016) XIUQIN LI et al.   Experimental and Therapeutic Medicine

Zwitterionic chitosan for the systemic treatment of sepsis

(2016) Eun Jung Cho et al.   Scientific Reports

Reactive Oxygen Species–Associated Molecular Signature Predicts Survival in Patients with Sepsis

(2016) Christian Bime et al.   Pulmonary Circulation

Reactive Oxygen Species in Endothelial Function　– From Disease to Adaptation –

(2015) Siobhan M. Craige et al.   CIRCULATION JOURNAL

Dexamethasone Suppressed LPS-Induced Matrix Metalloproteinase and Its Effect on Endothelial Glycocalyx Shedding

(2015) Na Cui et al.   MEDIATORS OF INFLAMMATION

Inflammation-Induced Increases in Plasma Endocan Levels are Associated With Endothelial Dysfunction in Humans in vivo

(2015) Laura AE Cox et al.   SHOCK

The role of platelets in inflammation

(2015) Robert Storey et al.   THROMBOSIS AND HAEMOSTASIS

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases

(2015) Paul R. Clark et al.   PLoS One

The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis

(2015) Lukas Martin et al.   PLoS One

miR-96 and miR-330 overexpressed and targeted AQP5 in lipopolysaccharide-induced rat lung damage of disseminated intravascular coagulation

(2014) Yanfen Zhang et al.   BLOOD COAGULATION & FIBRINOLYSIS

Lung-Targeted RNA Interference Against Angiopoietin-2 Ameliorates Multiple Organ Dysfunction and Death in Sepsis

(2014) Thomas Stiehl et al.   CRITICAL CARE MEDICINE

Elevated biomarkers of endothelial dysfunction/activation at ICU admission are associated with sepsis development

(2014) Alice G. Vassiliou et al.   CYTOKINE

Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions

(2014) W. Zheng et al.   GENES & DEVELOPMENT

ARF6 Inhibition Stabilizes the Vasculature and Enhances Survival during Endotoxic Shock

(2014) C. T. Davis et al.   JOURNAL OF IMMUNOLOGY

The role of Nox2-derived ROS in the development of cognitive impairment after sepsis

(2014) Marina S Hernandes et al.   Journal of Neuroinflammation

Antithrombin and mortality in severe pneumonia patients with sepsis-associated disseminated intravascular coagulation: an observational nationwide study

(2014) T. Tagami et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

(2014) Alpha A Fowler et al.   Journal of Translational Medicine

ICAM-1 Targeted Nanogels Loaded with Dexamethasone Alleviate Pulmonary Inflammation

(2014) M. Carme Coll Ferrer et al.   PLoS One

MicroRNA-147b Regulates Vascular Endothelial Barrier Function by Targeting ADAM15 Expression

(2014) Victor Chatterjee et al.   PLoS One

Levels of microRNA-181b and plasminogen activator inhibitor-1 are associated with hypertensive disorders complicating pregnancy

(2014) YAN-SHAN CHEN et al.   Experimental and Therapeutic Medicine

Role of Vitamin C in the Function of the Vascular Endothelium

(2013) James M. May et al.   ANTIOXIDANTS & REDOX SIGNALING

A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*

(2013) Jean-Louis Vincent et al.   CRITICAL CARE MEDICINE

MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways

(2013) Henry S. Cheng et al.   EMBO Molecular Medicine

Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy

(2013) Xavier Delabranche et al.   INTENSIVE CARE MEDICINE

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

(2013) Tilman Ziegler et al.   JOURNAL OF CLINICAL INVESTIGATION

Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies

(2013) Alan Mortensen et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Reactive Oxygen Species Modulate the Barrier Function of the Human Glomerular Endothelial Glycocalyx

(2013) Anurag Singh et al.   PLoS One

Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo

(2013) Vladimir V. Shuvaev et al.   PLoS One

Effect of TRIF on permeability and apoptosis in bovine microvascular endothelial cells exposed to lipopolysaccharide

(2013) Jason Dubbert et al.   VETERINARY JOURNAL

Endothelial connexin43 mediates acid-induced increases in pulmonary microvascular permeability

(2012) Kaushik Parthasarathi   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Microparticles: biomarkers and beyond

(2012) Dylan Burger et al.   CLINICAL SCIENCE

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

(2012) Sascha David et al.   CRITICAL CARE MEDICINE

Disseminated intravascular coagulation: a review for the internist

(2012) Marcel Levi et al.   Internal and Emergency Medicine

Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability

(2012) Weiquan Zhu et al.   NATURE

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recombinant thrombomodulin improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat LPS model

(2012) Toshiaki Iba et al.   THROMBOSIS RESEARCH

Vascular adhesion protein-1 and syndecan-1 in septic shock

(2011) M. SALLISALMI et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Recombinant Tissue Factor Pathway Inhibitor in Severe Community-acquired Pneumonia

(2011) Richard G. Wunderink et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer

(2011) S B Villadsen et al.   BRITISH JOURNAL OF CANCER

Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury*

(2011) Bernard J. Fisher et al.   CRITICAL CARE MEDICINE

Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis

(2011) Sascha David et al.   CYTOKINE

Complement-mediated injury and protection of endothelium: Lessons from atypical haemolytic uraemic syndrome

(2011) Heather Kerr et al.   IMMUNOBIOLOGY

Effects of Sepiapterin Infusion on Renal Oxygenation and Early Acute Renal Injury After Suprarenal Aortic Clamping in Rats

(2011) Matthieu Legrand et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Microparticles (Ectosomes) Shed by Stored Human Platelets Downregulate Macrophages and Modify the Development of Dendritic Cells

(2011) S. Sadallah et al.   JOURNAL OF IMMUNOLOGY

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin–lipopolysaccharide binding interactions

(2010) Rachel L. Soon et al.   ANALYTICAL BIOCHEMISTRY

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Angiopoietin-2 Stimulation of Endothelial Cells Induces αvβ3 Integrin Internalization and Degradation

(2010) Markus Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis

(2010) X. Wittebole et al.   MEDIATORS OF INFLAMMATION

Sepsis and Endothelial Permeability

(2010) Warren L. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combination of Imipenem and TAK-242, a Toll-Like Receptor 4 Signal Transduction Inhibitor, Improves Survival in a Murine Model of Polymicrobial Sepsis

(2010) Takukyu Sha et al.   SHOCK

Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endothelium

(2009) John X. Wilson   BIOFACTORS

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

(2009) K Takashima et al.   BRITISH JOURNAL OF PHARMACOLOGY

Detrimental hemodynamic and inflammatory effects of microparticles originating from septic rats*

(2009) Satar Mortaza et al.   CRITICAL CARE MEDICINE

The impact of the glycocalyx on microcirculatory oxygen distribution in critical illness

(2009) Daniel Chappell et al.   Current Opinion in Anesthesiology

The endothelium in acute lung injury/acute respiratory distress syndrome

(2009) Nikolaos A Maniatis et al.   Current Opinion in Critical Care

Sepsis and Major Abdominal Surgery Lead to Flaking of the Endothelial Glycocalix

(2009) Jochen Steppan et al.   JOURNAL OF SURGICAL RESEARCH

Albumin Augmentation Improves Condition of Guinea Pig Hearts After 4 hr of Cold Ischemia

(2009) Matthias Jacob et al.   TRANSPLANTATION

Monocyte-Endothelial Cell Interactions in the Development of Atherosclerosis

(2009) Javier Mestas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

(2008) J. Dalli et al.   BLOOD

The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury

(2008) Melanie van der Heijden et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Oxidative stress and anti-oxidative mobilization in burn injury

(2007) Arti Parihar et al.   BURNS