Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation

Telomeres: history, health, and hallmarks of aging

(2021) Deepavali Chakravarti et al.   CELL

Synergistic inflammatory signaling by cGAS may be involved in the development of atherosclerosis

(2021) Guan-Feng Lu et al.   Aging-US

Functional mechanisms and abnormalities of the nuclear lamina

(2021) Adam Karoutas et al.   NATURE CELL BIOLOGY

The Complexity of the cGAS-STING Pathway in CNS Pathologies

(2021) Amelia L. Fryer et al.   Frontiers in Neuroscience

Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging

(2021) Rashmi Upadhyay Pathak et al.   AGEING RESEARCH REVIEWS

Parental genome unification is highly error-prone in mammalian embryos

(2021) Tommaso Cavazza et al.   CELL

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

(2021) Mitchell L. Leibowitz et al.   NATURE GENETICS

Mechanistic origins of diverse genome rearrangements in cancer

(2021) Rashmi Dahiya et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

(2020) Isidro Cortés-Ciriano et al.   NATURE GENETICS

Unraveling LMNA Mutations in Metabolic Syndrome: Cellular Phenotype and Clinical Pitfalls

(2020) Camille Desgrouas et al.   Cells

Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome

(2020) Ray Kreienkamp et al.   Cells

Nuclear envelope dysfunction and its contribution to the aging process

(2020) Filipa Martins et al.   AGING CELL

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

(2020) Michele M. Nava et al.   CELL

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

The landscape of chromothripsis across adult cancer types

(2020) Natalia Voronina et al.   Nature Communications

Mitochondria in the Nuclei of Rat Myocardial Cells

(2020) Chupalav M. Eldarov et al.   Cells

Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells

(2020) Guillaume Bidault et al.   Cells

Lamin A/C Mechanotransduction in Laminopathies

(2020) Francesca Donnaloja et al.   Cells

Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone

(2020) Natividad Alcorta-Sevillano et al.   Cells

Nuclear Morphology and the Biology of Cancer Cells

(2020) Edgar G. Fischer   ACTA CYTOLOGICA

Nuclear Membrane Rupture and Its Consequences

(2020) John Maciejowski et al.   Annual Review of Cell and Developmental Biology

Lipid and protein dynamics that shape nuclear envelope identity

(2020) Shirin Bahmanyar et al.   MOLECULAR BIOLOGY OF THE CELL

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

(2020) Marina Vietri et al.   NATURE CELL BIOLOGY

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

(2020) John Maciejowski et al.   NATURE GENETICS

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

(2020) Manish Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Accumulation of LAP1:TRF2 Complex during DNA Damage Response Uncovers a Novel Role for LAP1

(2020) Cátia D. Pereira et al.   Cells

The nuclear envelope: target and mediator of the apoptotic process

(2020) Liora Lindenboim et al.   Cell Death Discovery

De Novo Variants in LMNB1 Cause Pronounced Syndromic Microcephaly and Disruption of Nuclear Envelope Integrity

(2020) Francesca Cristofoli et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Chromothripsis in human breast cancer

(2020) Michiel Bolkestein et al.   CANCER RESEARCH

TREX1 – Apex predator of cytosolic DNA metabolism

(2020) Sean R. Simpson et al.   DNA REPAIR

Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy

(2020) David A. Parry et al.   GENETICS IN MEDICINE

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

(2020) Gururaj Rao Kidiyoor et al.   Nature Communications

Chromothripsis drives the evolution of gene amplification in cancer

(2020) Ofer Shoshani et al.   NATURE

TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains

(2020) Jose A. Guerrero-Martínez et al.   Nature Communications

Lipid Droplet Nucleation

(2020) Abdou Rachid Thiam et al.   TRENDS IN CELL BIOLOGY

Signaling by cGAS–STING in Neurodegeneration, Neuroinflammation, and Aging

(2020) Bindu D. Paul et al.   TRENDS IN NEUROSCIENCES

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

(2019) Francesco Paonessa et al.   Cell Reports

The Nuclear Lamina as an Organizer of Chromosome Architecture

(2019) Yuri Y. Shevelyov et al.   Cells

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina

(2019) Bruce Nmezi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

(2019) Peter Ly et al.   NATURE GENETICS

Drug developers switch gears to inhibit STING

(2019) Cormac Sheridan   NATURE BIOTECHNOLOGY

The Structure of the Nuclear Pore Complex (An Update)

(2019) Daniel H. Lin et al.   Annual Review of Biochemistry

The Iceberg under Water: Unexplored Complexity of Chromoanagenesis in Congenital Disorders

(2019) Cinthya J. Zepeda-Mendoza et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

Neuroinflammation and the cGAS-STING pathway

(2019) Alfred C. Chin   JOURNAL OF NEUROPHYSIOLOGY

Cellular Plasticity in Cancer

(2019) Salina Yuan et al.   Cancer Discovery

Nuclear pores in genome architecture and enhancer function

(2019) Pau Pascual-Garcia et al.   CURRENT OPINION IN CELL BIOLOGY

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

(2019) Veijo T. Salo et al.   DEVELOPMENTAL CELL

Phosphatidic acid in membrane rearrangements

(2019) Mikhail A. Zhukovsky et al.   FEBS LETTERS

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle

(2019) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair

(2019) Muriel W Lambert   EXPERIMENTAL BIOLOGY AND MEDICINE

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

(2019) Francesco Maura et al.   Nature Communications

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

(2019) Maja Kneissig et al.   eLife

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

(2019) Ashley J. Earle et al.   NATURE MATERIALS

An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death

(2019) Natalie Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets

(2018) Anete Romanauska et al.   CELL

Polyploidy in tissue homeostasis and regeneration

(2018) Jan Inge Øvrebø et al.   DEVELOPMENT

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress

(2018) Afreen Haider et al.   DEVELOPMENTAL CELL

New biological research and understanding of Papanicolaou's test

(2018) Elizabeth R. Smith et al.   DIAGNOSTIC CYTOPATHOLOGY

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

(2018) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Constricted migration increases DNA damage and independently represses cell cycle

(2018) Charlotte R. Pfeifer et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Nuclear pores: the gate to neurodegeneration

(2018) Nan Li et al.   NATURE NEUROSCIENCE

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

(2018) Ray Kreienkamp et al.   Cell Reports

Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response

(2018) Simona Graziano et al.   Nucleus

Lipodystrophic laminopathies: Diagnostic clues

(2018) Cristina Guillín-Amarelle et al.   Nucleus

Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response

(2018) Simona Graziano et al.   Nucleus

Lipodystrophic laminopathies: Diagnostic clues

(2018) Cristina Guillín-Amarelle et al.   Nucleus

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome

(2018) Paul H. Kim et al.   Science Translational Medicine

Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions

(2018) Bing Ren et al.   AMERICAN JOURNAL OF PATHOLOGY

Assessment of fibroblast nuclear morphology aids interpretation of LMNA variants

(2018) Florence H. J. van Tienen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Breaking Bad: How Viruses Subvert the Cell Cycle

(2018) Ying Fan et al.   Frontiers in Cellular and Infection Microbiology

Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis

(2017) Can Zhou et al.   HUMAN MOLECULAR GENETICS

Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb

(2017) Zhe Yang et al.   MOLECULAR CANCER RESEARCH

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

(2017) Kristen M. Turner et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation

(2017) Vidhu Mathur et al.   NEURON

Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport

(2017) Fatima Gasset-Rosa et al.   NEURON

Nuclear envelopathies: a complex LINC between nuclear envelope and pathology

(2017) Alexandre Janin et al.   Orphanet Journal of Rare Diseases

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOBEC3B, a molecular driver of mutagenesis in human cancers

(2017) Jun Zou et al.   Cell and Bioscience

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

(2016) Stephanie A. Yazinski et al.   Annual Review of Genetics

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Nuclear morphologies: their diversity and functional relevance

(2016) Benjamin M. Skinner et al.   CHROMOSOMA

Lamins and metabolism

(2016) C. Charar et al.   CLINICAL SCIENCE

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

(2016) Bess Frost et al.   CURRENT BIOLOGY

A-type Lamins Form Distinct Filamentous Networks with Differential Nuclear Pore Complex Associations

(2016) Wei Xie et al.   CURRENT BIOLOGY

Deep nuclear invaginations are linked to cytoskeletal filaments – integrated bioimaging of epithelial cells in 3D culture

(2016) Danielle M. Jorgens et al.   JOURNAL OF CELL SCIENCE

Breaching the Barrier—The Nuclear Envelope in Virus Infection

(2016) Thomas C. Mettenleiter   JOURNAL OF MOLECULAR BIOLOGY

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

(2016) Faiyaz Notta et al.   NATURE

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

(2016) Allyson J. Merrell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

On TADs and LADs: Spatial Control Over Gene Expression

(2016) Adriana Gonzalez-Sandoval et al.   TRENDS IN GENETICS

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

(2016) Valentine Comaills et al.   Cell Reports

Mammalian telomeres and their partnership with lamins

(2016) Romina Burla et al.   Nucleus

Mammalian telomeres and their partnership with lamins

(2016) Romina Burla et al.   Nucleus

A Heterozygous ZMPSTE24 Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy

(2016) Damien Galant et al.   Cells

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

A germline chromothripsis event stably segregating in 11 individuals through three generations

(2015) Birgitte Bertelsen et al.   GENETICS IN MEDICINE

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

(2015) Brian D. Freibaum et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

(2015) Juan Fu et al.   Science Translational Medicine

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness

(2015) Takashi Furusawa et al.   Nature Communications

Nuclear entry of DNA viruses

(2015) Nikta Fay et al.   Frontiers in Microbiology

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

(2014) Amit Kumar et al.   CELL

Linker of Nucleoskeleton and Cytoskeleton Complex Proteins in Cardiac Structure, Function, and Disease

(2014) Matthew J Stroud et al.   CIRCULATION RESEARCH

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

(2014) M. Yu et al.   SCIENCE

Nesprin-1 role in DNA damage response

(2014) Ilknur Sur et al.   Nucleus

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

(2013) Oliver Dreesen et al.   JOURNAL OF CELL BIOLOGY

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

(2013) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Inner Nuclear Envelope Proteins SUN1 and SUN2 Play a Prominent Role in the DNA Damage Response

(2012) Kai Lei et al.   CURRENT BIOLOGY

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

Conditional expression of the TVA receptor allows clonal analysis of descendents from Cre-expressing progenitor cells

(2011) Kevin T. Beier et al.   DEVELOPMENTAL BIOLOGY

High prevalence of laminopathies among patients with metabolic syndrome

(2011) Anne Dutour et al.   HUMAN MOLECULAR GENETICS

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Nuclear Envelope Disruption Involving Host Caspases Plays a Role in the Parvovirus Replication Cycle

(2011) S. Cohen et al.   JOURNAL OF VIROLOGY

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition

(2011) Oliver G McDonald et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect

(2011) V. L. R. M. Verstraeten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The perinuclear actin cap in health and disease

(2011) Shyam B. Khatau et al.   Nucleus

Promotion of tumor development in prostate cancer by progerin

(2010) Yong Tang et al.   Cancer Cell International

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells

(2009) Maximiliano A. D'Angelo et al.   CELL

Lamin B1 maintains the functional plasticity of nucleoli

(2009) C. Martin et al.   JOURNAL OF CELL SCIENCE

Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1

(2008) Silvia Martin-Lluesma et al.   HEPATOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE