Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

(2016) Paul W. Tetteh et al.   Cell Stem Cell

Cellular Homeostasis and Repair in the Mammalian Liver

(2015) Ben Z. Stanger   Annual Review of Physiology

Recent Advances in Cell Replacement Therapies for the Treatment of Type 1 Diabetes

(2015) Kathryn Cogger et al.   ENDOCRINOLOGY

Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments

(2015) Margaret A. Goodell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling

(2015) Jean Defourny et al.   Nature Communications

Turning terminally differentiated skeletal muscle cells into regenerative progenitors

(2015) Heng Wang et al.   Nature Communications

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung

(2015) Rajan Jain et al.   Nature Communications

The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma

(2015) Nathan M Krah et al.   eLife

Dynamics of Lgr6 + Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis

(2015) Anja Füllgrabe et al.   Stem Cell Reports

Conversion of one cell type into another: implications for understanding organ development, pathogenesis of cancer and generating cells for therapy: Figure 1

(2014) James L. Corbett et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Liver cell reprogramming

(2014) Kilangsungla Yanger et al.   CELL CYCLE

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

Stem Cells to Insulin Secreting Cells: Two Steps Forward and Now a Time to Pause?

(2014) Jake A. Kushner et al.   Cell Stem Cell

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells

(2014) Rui Zhao et al.   DEVELOPMENTAL CELL

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration

(2014) Michio W. Painter et al.   NEURON

Sequential histone-modifying activities determine the robustness of transdifferentiation

(2014) S. Zuryn et al.   SCIENCE

Plasticity of epithelial stem cells in tissue regeneration

(2014) C. Blanpain et al.   SCIENCE

De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts

(2014) Yi-Ju Chen et al.   Cell Reports

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations

(2013) Mahalia E. Page et al.   Cell Stem Cell

Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species

(2013) Tatiana Sandoval-Guzmán et al.   Cell Stem Cell

Transdifferentiation and remodeling of post-embryonic C. elegans cells by a single transcription factor

(2013) M. R. Riddle et al.   DEVELOPMENT

Adrenocortical Zonation Results from Lineage Conversion of Differentiated Zona Glomerulosa Cells

(2013) Bethany D. Freedman et al.   DEVELOPMENTAL CELL

Control of Cell Identity in Pancreas Development and Regeneration

(2013) Ben Z. Stanger et al.   GASTROENTEROLOGY

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

Spatial organization within a niche as a determinant of stem-cell fate

(2013) Panteleimon Rompolas et al.   NATURE

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

(2013) Luc Baeyens et al.   NATURE BIOTECHNOLOGY

Detection and minimally invasive treatment of early squamous lung cancer

(2013) Johannes M.A. Daniels et al.   Therapeutic Advances in Medical Oncology

Regeneration and Transdetermination in Drosophila Imaginal Discs

(2012) Melanie I. Worley et al.   Annual Review of Genetics

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice

(2012) Augusto Villanueva et al.   GASTROENTEROLOGY

Hydra, a fruitful model system for 270 years

(2012) Brigitte Galliot   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The planarian neoblast: the rambling history of its origin and some current black boxes

(2012) Jaume Baguñ   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

(2012) Sayaka Sekiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Paracrine Interactions Within Islets of Langerhans

(2012) Duk-Su Koh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Skin shedding and tissue regeneration in African spiny mice (Acomys)

(2012) Ashley W. Seifert et al.   NATURE

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

Dynamics between Stem Cells, Niche, and Progeny in the Hair Follicle

(2011) Ya-Chieh Hsu et al.   CELL

The stem cell niche: lessons from the Drosophila testis

(2011) M. de Cuevas et al.   DEVELOPMENT

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

The Cellular Basis for Animal Regeneration

(2011) Elly M. Tanaka et al.   DEVELOPMENTAL CELL

Epigenetic reprogramming during tissue regeneration

(2011) Tomonori Katsuyama et al.   FEBS LETTERS

Risk of Malignant Progression in Barrett's Esophagus Patients: Results from a Large Population-Based Study

(2011) S. Bhat et al.   JNCI-Journal of the National Cancer Institute

Deregulation of Hippo kinase signalling in Human hepatic malignancies

(2011) Hua Li et al.   LIVER INTERNATIONAL

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

(2011) Pengyu Huang et al.   NATURE

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

(2011) Chris Jopling et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Incidence of Adenocarcinoma among Patients with Barrett's Esophagus

(2011) Frederik Hvid-Jensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Transient Inactivation of Rb and ARF Yields Regenerative Cells from Postmitotic Mammalian Muscle

(2010) Kostandin V. Pajcini et al.   Cell Stem Cell

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

Oocyte-type linker histone B4 is required for transdifferentiation of somatic cells in vivo

(2010) Nobuyasu Maki et al.   FASEB JOURNAL

Schwann Cell Dedifferentiation Is Independent of Mitogenic Signaling and Uncoupled to Proliferation

(2010) Paula V. Monje et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment

(2010) T. Nakagawa et al.   SCIENCE

Physiological cellular reprogramming and cancer

(2010) Fernando Abollo-Jiménez et al.   SEMINARS IN CANCER BIOLOGY

A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration

(2009) Valentina Greco et al.   Cell Stem Cell

Dedifferentiating Spermatogonia Outcompete Somatic Stem Cells for Niche Occupancy in the Drosophila Testis

(2009) X. Rebecca Sheng et al.   Cell Stem Cell

Notch signaling controls liver development by regulating biliary differentiation

(2009) Y. Zong et al.   DEVELOPMENT

Expression of stem cell pluripotency factors during regeneration in newts

(2009) Nobuyasu Maki et al.   DEVELOPMENTAL DYNAMICS

Barrett's oesophagus

(2009) Nicholas J Shaheen et al.   LANCET

Cells keep a memory of their tissue origin during axolotl limb regeneration

(2009) Martin Kragl et al.   NATURE

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro transdifferentiation of adult hematopoietic stem cells: An alternative source of engraftable hepatocytes

(2008) Satish Khurana et al.   JOURNAL OF HEPATOLOGY

Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation

(2008) Rhona Mirsky et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Mouse differentiating spermatogonia can generate germinal stem cells in vivo

(2008) Vilma Barroca et al.   NATURE CELL BIOLOGY

A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation

(2008) S. Jarriault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA