Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

(2016) Andrew M. Cobb et al.   AGING CELL

Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody

(2016) Ian Holt et al.   BMC CELL BIOLOGY

The increasing relevance of nuclear envelope myopathies

(2016) Peter Meinke et al.   CURRENT OPINION IN NEUROLOGY

Targeting the sarcomere to correct muscle function

(2015) Peter M. Hwang et al.   NATURE REVIEWS DRUG DISCOVERY

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation

(2014) Antoine Muchir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells

(2014) M. H. Wilson et al.   DEVELOPMENT

Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response

(2014) Indroneal Banerjee et al.   PLoS Genetics

Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization

(2014) Peter Meinke et al.   PLoS Genetics

SUN proteins and nuclear envelope spacing

(2014) Natalie E Cain et al.   Nucleus

Nuclear Positioning

(2013) Gregg G. Gundersen et al.   CELL

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Contribution of SUN1 Mutations to the Pathomechanism in Muscular Dystrophies

(2013) Ping Li et al.   HUMAN MUTATION

Dilated cardiomyopathy: the complexity of a diverse genetic architecture

(2013) Ray E. Hershberger et al.   Nature Reviews Cardiology

Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells

(2012) Meredith H. Wilson et al.   JOURNAL OF CELL SCIENCE

Multiple Novel Nesprin-1 and Nesprin-2 Variants Act as Versatile Tissue-Specific Intracellular Scaffolds

(2012) Dipen Rajgor et al.   PLoS One

The LINC complex and human disease

(2011) Peter Meinke et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of the Spectrin-Like Domains of Nesprin-1α by the Evolutionarily Conserved “Adaptive” Domain

(2010) Zhixia Zhong et al.   Cellular and Molecular Bioengineering

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

(2010) Wei Wu et al.   CIRCULATION

The genetics of dilated cardiomyopathy

(2010) Lisa Dellefave et al.   CURRENT OPINION IN CARDIOLOGY

Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development

(2010) K. Natalie Randles et al.   DEVELOPMENTAL DYNAMICS

Novel LMNA mutations in patients with Emery-Dreifuss muscular dystrophy and functional characterization of four LMNA mutations

(2010) Juergen Scharner et al.   HUMAN MUTATION

Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis

(2010) Michaela Brosig et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma–lamin A complexes

(2010) Javier Rodríguez et al.   JOURNAL OF CELL BIOLOGY

Identification of an emerin–β-catenin complex in the heart important for intercalated disc architecture and β-catenin localisation

(2009) Matthew A. Wheeler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nesprin 1 is critical for nuclear positioning and anchorage

(2009) Jianlin Zhang et al.   HUMAN MOLECULAR GENETICS

Novel Nuclear Nesprin-2 Variants Tether Active Extracellular Signal-regulated MAPK1 and MAPK2 at Promyelocytic Leukemia Protein Nuclear Bodies and Act to Regulate Smooth Muscle Cell Proliferation

(2009) Derek T. Warren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zili Inhibits Transforming Growth Factor-β Signaling by Interacting with Smad4

(2009) Huaqin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian SUN Protein Interaction Networks at the Inner Nuclear Membrane and Their Role in Laminopathy Disease Processes

(2009) Farhana Haque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nesprin-1 mutations in human and murine cardiomyopathy

(2009) Megan J. Puckelwartz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice

(2009) K. Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoforms

(2008) Jennifer G. Simpson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms

(2008) Zhenyue Chen et al.   CARDIOVASCULAR RESEARCH

Differentiation of C2C12 myoblasts expressing lamin A mutated at a site responsible for Emery–Dreifuss muscular dystrophy is improved by inhibition of the MEK–ERK pathway and stimulation of the PI3-kinase pathway

(2008) Catherine Favreau et al.   EXPERIMENTAL CELL RESEARCH

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness

(2008) P.J. Stewart-Hutchinson et al.   EXPERIMENTAL CELL RESEARCH

Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice

(2008) M. J. Puckelwartz et al.   HUMAN MOLECULAR GENETICS

Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope

(2008) José María González et al.   JOURNAL OF CELL BIOLOGY

Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin

(2008) Y. Luke et al.   JOURNAL OF CELL SCIENCE

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols