- Home
- Publications
- Publication Search
- Publication Details
Title
The Complexity of the cGAS-STING Pathway in CNS Pathologies
Authors
Keywords
-
Journal
Frontiers in Neuroscience
Volume 15, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-02-09
DOI
10.3389/fnins.2021.621501
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Interferon-β plays a detrimental role in experimental traumatic brain injury by enhancing neuroinflammation that drives chronic neurodegeneration
- (2020) James P. Barrett et al. JOURNAL OF NEUROSCIENCE
- Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
- (2020) Ethan R. Roy et al. JOURNAL OF CLINICAL INVESTIGATION
- Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage
- (2020) Yucong Peng et al. Journal of Neuroinflammation
- cGAS/STING Pathway Activation Contributes to Delayed Neurodegeneration in Neonatal Hypoxia-Ischemia Rat Model: Possible Involvement of LINE-1
- (2020) Marcin Gamdzyk et al. MOLECULAR NEUROBIOLOGY
- Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
- (2020) Manish Sharma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
- (2020) Chien-Hsiung Yu et al. CELL
- Neuroinflammatory responses of microglia in central nervous system trauma
- (2020) Donald C Shields et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- IFN Regulatory Factor 3 in Health and Disease
- (2020) Thomas M. Petro JOURNAL OF IMMUNOLOGY
- Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity
- (2020) Henrique Lemos et al. Journal for ImmunoTherapy of Cancer
- The STING-IFN-β-Dependent Axis Is Markedly Low in Patients with Relapsing-Remitting Multiple Sclerosis
- (2020) Lars Masanneck et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Ataxia‐telangiectasia: A review of clinical features and molecular pathology
- (2019) Parisa Amirifar et al. PEDIATRIC ALLERGY AND IMMUNOLOGY
- Structural basis of STING binding with and phosphorylation by TBK1
- (2019) Conggang Zhang et al. NATURE
- Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
- (2019) Guijun Shang et al. NATURE
- Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
- (2019) Arshed Nazmi et al. GLIA
- Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation
- (2019) Yuk Yuen Lan et al. AGING CELL
- Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy
- (2019) Min Luo et al. JOURNAL OF CONTROLLED RELEASE
- Toll-like receptors in the pathogenesis of neuroinflammation
- (2019) V. Kumar JOURNAL OF NEUROIMMUNOLOGY
- STING is required for host defense against neuropathological West Nile virus infection
- (2019) Kathryn McGuckin Wuertz et al. PLoS Pathogens
- Bioactive modulators targeting STING adaptor in cGAS-STING pathway
- (2019) Xi Feng et al. DRUG DISCOVERY TODAY
- Aberrant ER-stress induced neuronal-IFNβ elicits white matter injury due to microglial activation and T-cell infiltration after TBI
- (2019) Tanusree Sen et al. JOURNAL OF NEUROSCIENCE
- Interferon target-gene expression and epigenomic signatures in health and disease
- (2019) Franck J. Barrat et al. NATURE IMMUNOLOGY
- Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective
- (2019) Han Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis
- (2019) Tatyana A. Shelkovnikova et al. Cell Reports
- Type I Interferons and Cancer: An Evolving Story Demanding Novel Clinical Applications
- (2019) Eleonora Aricò et al. Cancers
- Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus
- (2018) Yasuhiro Kato et al. ANNALS OF THE RHEUMATIC DISEASES
- TMEM173 variants and potential importance to human biology and disease
- (2018) Seema Patel et al. GENES AND IMMUNITY
- Targeting IRF3 as a YAP agonist therapy against gastric cancer
- (2018) Shi Jiao et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy
- (2018) David R. Wilson et al. Nanomedicine-Nanotechnology Biology and Medicine
- Beyond ALS and FTD: the phenotypic spectrum of TBK1 mutations includes PSP-like and cerebellar phenotypes
- (2018) Carlo Wilke et al. NEUROBIOLOGY OF AGING
- Parkin and PINK1 mitigate STING-induced inflammation
- (2018) Danielle A. Sliter et al. NATURE
- Targeting STING with covalent small-molecule inhibitors
- (2018) Simone M. Haag et al. NATURE
- Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
- (2018) Anne Louise Hansen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- STING SNP R293Q Is Associated with a Decreased Risk of Aging-Related Diseases
- (2018) Lutz Hamann et al. GERONTOLOGY
- STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury
- (2018) Amar Abdullah et al. Journal of Neuroinflammation
- cGAS Micro-Manages Genotoxic Stress
- (2017) Mona Motwani et al. IMMUNITY
- Senescence and aging: Causes, consequences, and therapeutic avenues
- (2017) Domhnall McHugh et al. JOURNAL OF CELL BIOLOGY
- Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death
- (2017) Bridget Larkin et al. JOURNAL OF IMMUNOLOGY
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- (2017) Selene Glück et al. NATURE CELL BIOLOGY
- The far-reaching scope of neuroinflammation after traumatic brain injury
- (2017) Dennis W. Simon et al. Nature Reviews Neurology
- Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation
- (2017) Vidhu Mathur et al. NEURON
- TBK1: a new player in ALS linking autophagy and neuroinflammation
- (2017) James A. Oakes et al. Molecular Brain
- Herpes Simplex Encephalitis: an Update
- (2017) John W. Gnann et al. Current Infectious Disease Reports
- Familial chilblain lupus due to a gain-of-function mutation in STING
- (2016) Nadja König et al. ANNALS OF THE RHEUMATIC DISEASES
- Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson's disease
- (2016) Bevan S. Main et al. GLIA
- The Common R71H-G230A-R293Q HumanTMEM173Is a Null Allele
- (2016) Seema Patel et al. JOURNAL OF IMMUNOLOGY
- Neuroinflammation: the devil is in the details
- (2016) Damon J. DiSabato et al. JOURNAL OF NEUROCHEMISTRY
- Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration
- (2016) Hongwei Qin et al. JOURNAL OF NEUROSCIENCE
- Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
- (2016) Qing Chen et al. NATURE
- Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
- (2016) Qi Chen et al. NATURE IMMUNOLOGY
- Ataxia telangiectasia: a review
- (2016) Cynthia Rothblum-Oviatt et al. Orphanet Journal of Rare Diseases
- Human TBK1: A Gatekeeper of Neuroinflammation
- (2016) Liyana Ahmad et al. TRENDS IN MOLECULAR MEDICINE
- Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
- (2016) Line S. Reinert et al. Nature Communications
- Type-I Interferon Responses: From Friend to Foe in the Battle against Chronic Viral Infection
- (2016) Armstrong Murira et al. Frontiers in Immunology
- Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype
- (2016) Myles R. Minter et al. Acta Neuropathologica Communications
- The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy
- (2015) Robert O. Watson et al. Cell Host & Microbe
- DNA sensors are expressed in astrocytes and microgliain vitroand are upregulated during gliosis in neurodegenerative disease
- (2015) Donal J. Cox et al. GLIA
- DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
- (2015) Anetta Härtlova et al. IMMUNITY
- Mitochondrial DNA stress primes the antiviral innate immune response
- (2015) A. Phillip West et al. NATURE
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- Suppression of systemic autoimmunity by the innate immune adaptor STING
- (2015) Shruti Sharma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
- (2015) E. T. Cirulli et al. SCIENCE
- Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
- (2015) S. Liu et al. SCIENCE
- STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
- (2015) Juan Fu et al. Science Translational Medicine
- Rat and human STINGs profile similarly towards anticancer/antiviral compounds
- (2015) Heng Zhang et al. Scientific Reports
- Interferon-Stimulated Genes: A Complex Web of Host Defenses
- (2014) William M. Schneider et al. Annual Review of Immunology
- The role of type I interferons in intestinal infection, homeostasis, and inflammation
- (2014) Hyeseon Cho et al. IMMUNOLOGICAL REVIEWS
- Type I Interferon in the Pathogenesis of Lupus
- (2014) M. K. Crow JOURNAL OF IMMUNOLOGY
- Activation of the STING Adaptor Attenuates Experimental Autoimmune Encephalitis
- (2014) H. Lemos et al. JOURNAL OF IMMUNOLOGY
- Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1
- (2014) T. Abe et al. JOURNAL OF VIROLOGY
- Evaluating TBK1 as a Therapeutic Target in Cancers with Activated IRF3
- (2014) Asli Muvaffak et al. MOLECULAR CANCER RESEARCH
- Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
- (2014) Lingyin Li et al. Nature Chemical Biology
- Activated STING in a Vascular and Pulmonary Syndrome
- (2014) Yin Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inflammation-driven carcinogenesis is mediated through STING
- (2014) Jeonghyun Ahn et al. Nature Communications
- STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer
- (2014) D. Chandra et al. Cancer Immunology Research
- Anticancer Flavonoids Are Mouse-Selective STING Agonists
- (2013) Sujeong Kim et al. ACS Chemical Biology
- Fueling autoimmunity: type I interferon in autoimmune diseases
- (2013) Jeremy Di Domizio et al. Expert Review of Clinical Immunology
- Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses
- (2013) L. Huang et al. JOURNAL OF IMMUNOLOGY
- Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
- (2013) J. Conlon et al. JOURNAL OF IMMUNOLOGY
- Progressive Neurodegeneration After Experimental Brain Trauma
- (2013) David J. Loane et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
- (2013) Xu Zhang et al. MOLECULAR CELL
- ELF4 is critical for induction of type I interferon and the host antiviral response
- (2013) Fuping You et al. NATURE IMMUNOLOGY
- Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease
- (2013) Juliet M. Taylor et al. NEUROBIOLOGY OF AGING
- STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
- (2013) J. Petrasek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
- (2013) X.-D. Li et al. SCIENCE
- Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection
- (2013) R. K. Subbarao Malireddi et al. Frontiers in Cellular and Infection Microbiology
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
- (2012) Y. Tanaka et al. Science Signaling
- The Mechanism of Action of Interferon-β in Relapsing Multiple Sclerosis
- (2011) Bernd C. Kieseier CNS DRUGS
- AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function
- (2011) D. G. Hardie GENES & DEVELOPMENT
- STING is a direct innate immune sensor of cyclic di-GMP
- (2011) Dara L. Burdette et al. NATURE
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Type I Interferons Mediate the Innate Cytokine Response to Recombinant Fowlpox Virus but Not the Induction of Plasmacytoid Dendritic Cell-Dependent Adaptive Immunity
- (2010) E. L. Lousberg et al. JOURNAL OF VIROLOGY
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
- (2009) Hiroki Ishikawa et al. NATURE
- Innate immune response to viral infection
- (2008) Shohei Koyama et al. CYTOKINE
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
- Phenotype and Course of Hutchinson–Gilford Progeria Syndrome
- (2008) Melissa A. Merideth et al. NEW ENGLAND JOURNAL OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started