Cell-Free DNA in Rheumatoid Arthritis

A Cationic Metal–Organic Framework to Scavenge Cell-Free DNA for Severe Sepsis Management

(2021) Feng Liu et al.   NANO LETTERS

The Trinity of cGAS, TLR9, and ALRs Guardians of the Cellular Galaxy Against Host-Derived Self-DNA

(2021) Vijay Kumar   Frontiers in Immunology

Circulating Free DNA and Its Emerging Role in Autoimmune Diseases

(2021) Patricia Mondelo-Macía et al.   Journal of Personalized Medicine

Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living

(2020) Ellen Heitzer et al.   TRENDS IN MOLECULAR MEDICINE

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Treatment of severe sepsis with nanoparticulate cell-free DNA scavengers

(2020) Jianati Dawulieti et al.   Science Advances

Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response

(2020) Dmitry S. Mikhaylenko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The genetics of rheumatoid arthritis

(2020) Laura E Dedmon   RHEUMATOLOGY

Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients

(2020) Svend Birkelund et al.   Clinical Proteomics

Identification of Specific Joint-Inflammatogenic Cell-Free DNA Molecules From Synovial Fluids of Patients With Rheumatoid Arthritis

(2020) Cong Dong et al.   Frontiers in Immunology

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Controlling cancer-induced inflammation with a nucleic acid scavenger prevents lung metastasis in murine models of breast cancer

(2020) Eda K. Holl et al.   MOLECULAR THERAPY

A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis

(2019) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

Liquid Biopsy: General Concepts

(2019) Geoffroy Poulet et al.   ACTA CYTOLOGICA

Life and death of circulating cell-free DNA

(2019) Anatoli Kustanovich et al.   CANCER BIOLOGY & THERAPY

Epigenetic Changes in the Pathogenesis of Rheumatoid Arthritis

(2019) Marina V. Nemtsova et al.   Frontiers in Genetics

DNA Methylation as a Future Therapeutic and Diagnostic Target in Rheumatoid Arthritis

(2019) Marzena Ciechomska et al.   Cells

The evolution in our understanding of the genetics of rheumatoid arthritis and the impact on novel drug discovery

(2019) Filip Machaj et al.   Expert Opinion on Drug Discovery

Accumulation of cytosolic dsDNA contributes to fibroblast-like synoviocytes-mediated rheumatoid arthritis synovial inflammation

(2019) Jingnan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Expression and activity of AIM2-inflammasome in rheumatoid arthritis patients

(2019) Gwendolyne Méndez-Frausto et al.   IMMUNOBIOLOGY

Complement C1q synergizes with PTX3 in promoting NLRP3 inflammasome over-activation and pyroptosis in rheumatoid arthritis

(2019) Xun-yao Wu et al.   JOURNAL OF AUTOIMMUNITY

An overview of apoptosis assays detecting DNA fragmentation

(2018) Pavlína Majtnerová et al.   MOLECULAR BIOLOGY REPORTS

Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis

(2018) Ibtehaj Naqvi et al.   MOLECULAR THERAPY

Clinical Utility of Analyzing Circulating Tumor DNA in Patients with Metastatic Colorectal Cancer

(2018) Yoshiaki Nakamura et al.   ONCOLOGIST

Anti-cytokine therapy and plasma DNA in patients with rheumatoid arthritis

(2018) Lucia Lauková et al.   RHEUMATOLOGY INTERNATIONAL

Review: The Tumor-Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine

(2018) Sungyong You et al.   Arthritis & Rheumatology

Identification of differentially expressed genes in synovial tissue of rheumatoid arthritis and osteoarthritis in patients

(2018) Wen Chao Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Apoptosis and apoptotic body: disease message and therapeutic target potentials

(2018) Xuebo Xu et al.   BIOSCIENCE REPORTS

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

(2018) Huiyi Liang et al.   Nature Communications

Association Between MTHFR C677T Polymorphism and Methotrexate Treatment Outcome in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis

(2017) Wenjing Shao et al.   Genetic Testing and Molecular Biomarkers

Immunopathogenesis of Rheumatoid Arthritis

(2017) Gary S. Firestein et al.   IMMUNITY

Macrophage Extracellular Traps: A Scoping Review

(2017) Ryan S. Doster et al.   Journal of Innate Immunity

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Are gene polymorphisms related to treatment outcomes of methotrexate in patients with rheumatoid arthritis? A systematic review and meta-analysis

(2017) Yuehong Chen et al.   PHARMACOGENOMICS

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Characterization of the release and biological significance of cell-free DNA from breast cancer cell lines

(2017) Wei Wang et al.   Oncotarget

Circulating cell-free DNA: A promising marker of regional lymphonode metastasis in breast cancer patients

(2017) M. Agostini et al.   Cancer Biomarkers

Meta-analysis revealsPTPN221858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population

(2016) Gowher Nabi et al.   AUTOIMMUNITY

Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin

(2016) Matthew W. Snyder et al.   CELL

The potential of liquid biopsies

(2016) Anna Buder et al.   CURRENT OPINION IN ONCOLOGY

Genetic data: The new challenge of personalized medicine, insights for rheumatoid arthritis patients

(2016) George N. Goulielmos et al.   GENE

Circulating cell free DNA: a marker to predict the therapeutic response for biological DMARDs in rheumatoid arthritis

(2016) Teppei Hashimoto et al.   International Journal of Rheumatic Diseases

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of tissue-specific cell death using methylation patterns of circulating DNA

(2016) Roni Lehmann-Werman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis

(2016) Young Ho Lee et al.   RHEUMATOLOGY INTERNATIONAL

Human neutrophils in auto-immunity

(2016) Nathalie Thieblemont et al.   SEMINARS IN IMMUNOLOGY

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis

(2016) Darren Plant et al.   Arthritis & Rheumatology

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

(2015) Si Ming Man et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Analysis of associations between polymorphisms within genes coding for tumour necrosis factor (TNF)-alpha and TNF receptors and responsiveness to TNF-alpha blockers in patients with rheumatoid arthritis

(2015) Jerzy Swierkot et al.   JOINT BONE SPINE

Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

(2015) Yan Wang et al.   MEDIATORS OF INFLAMMATION

Genetics of rheumatoid arthritis in Asia—present and future

(2015) Kazuhiko Yamamoto et al.   Nature Reviews Rheumatology

A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis

(2015) A Julià et al.   PHARMACOGENOMICS JOURNAL

Genetic Variations in Pattern Recognition Receptor Loci Are Associated with Anti-TNF Response in Patients with Rheumatoid Arthritis

(2015) Jacob Sode et al.   PLoS One

Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets

(2015) John W. Whitaker et al.   PLoS One

DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS

(2015) John R Glossop et al.   Epigenomics

Digital PCR analysis of plasma cell-free DNA for non-invasive detection of drug resistance mechanisms in EGFR mutant NSCLC: Correlation with paired tumor samples

(2015) Hidenobu Ishii et al.   Oncotarget

Strategies for H-score Normalization of Preanalytical Technical Variables with Potential Utility to Immunohistochemical-Based Biomarker Quantitation in Therapeutic Reponse Diagnostics

(2015) William E. Pierceall et al.   Analytical Cellular Pathology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Circulating cell-free DNA in serum as a biomarker for diagnosis and prognostic prediction of colorectal cancer

(2014) T B Hao et al.   BRITISH JOURNAL OF CANCER

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1  Released from Dying Cells

(2014) T. Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

The disease formerly known as rheumatoid arthritis

(2014) Gary S Firestein   ARTHRITIS RESEARCH & THERAPY

Circulating free mitochondrial DNA concentration and its association with erlotinib treatment in patients with adenocarcinoma of the lung

(2014) CHU-YUN HUANG et al.   Oncology Letters

The 158VV Fcgamma receptor 3A genotype is associated with response to rituximab in rheumatoid arthritis: results of an Italian multicentre study

(2013) Luca Quartuccio et al.   ANNALS OF THE RHEUMATIC DISEASES

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

(2013) S. Ueki et al.   BLOOD

Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression

(2013) Lorenzo de la Rica et al.   JOURNAL OF AUTOIMMUNITY

Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes

(2013) K. Nakano et al.   JOURNAL OF IMMUNOLOGY

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

(2013) John W Whitaker et al.   Genome Medicine

Fcγ receptor type IIIA polymorphism influences treatment outcomes in patients with rheumatoid arthritis treated with rituximab

(2012) A Ruyssen-Witrand et al.   ANNALS OF THE RHEUMATIC DISEASES

DNA methylome signature in rheumatoid arthritis

(2012) Kazuhisa Nakano et al.   ANNALS OF THE RHEUMATIC DISEASES

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nucleic acid-binding polymers as anti-inflammatory agents

(2011) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treating rheumatoid arthritis to target: recommendations of an international task force

(2010) J. S. Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker

(2009) Jörg Ellinger et al.   BJU INTERNATIONAL

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

Nucleic acid-sensing Toll-like receptors: Beyond ligand search☆

(2008) K MIYAKE   ADVANCED DRUG DELIVERY REVIEWS