Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets

Computational schemes for the prediction and annotation of enhancers from epigenomic assays

(2015) John W. Whitaker et al.   METHODS

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

The Rheumatoid Arthritis Risk GeneLBHRegulates Growth in Fibroblast-like Synoviocytes

(2015) Anna-Karin H. Ekwall et al.   Arthritis & Rheumatology

Phosphoinositide 3-Kinase   Regulates Migration and Invasion of Synoviocytes in Rheumatoid Arthritis

(2014) B. Bartok et al.   JOURNAL OF IMMUNOLOGY

Essential Role of Elmo1 in Dock2-Dependent Lymphocyte Migration

(2014) C. Stevenson et al.   JOURNAL OF IMMUNOLOGY

Predicting the human epigenome from DNA motifs

(2014) John W Whitaker et al.   NATURE METHODS

Network analysis identifies protein clusters of functional importance in juvenile idiopathic arthritis

(2014) Adam Stevens et al.   ARTHRITIS RESEARCH & THERAPY

Prolonged Tumor Necrosis Factor α Primes Fibroblast-like Synoviocytes in a Gene-Specific Manner by Altering Chromatin

(2014) Christopher Sohn et al.   Arthritis & Rheumatology

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

(2013) Wei Xie et al.   CELL

Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes

(2013) K. Nakano et al.   JOURNAL OF IMMUNOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Genetic insights into common pathways and complex relationships among immune-mediated diseases

(2013) Miles Parkes et al.   NATURE REVIEWS GENETICS

Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis

(2013) Hongyan Li et al.   Nature Communications

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

(2013) John W Whitaker et al.   Genome Medicine

DNA methylome signature in rheumatoid arthritis

(2012) Kazuhisa Nakano et al.   ANNALS OF THE RHEUMATIC DISEASES

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

(2012) Eli A Stahl et al.   NATURE GENETICS

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

(2012) K. Hanawa-Suetsugu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor- , in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

(2011) G. R. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Transcriptome analysis reveals specific changes in osteoarthritis synovial fibroblasts

(2011) Manuel J Del Rey et al.   ANNALS OF THE RHEUMATIC DISEASES

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

(2011) G. C. Hon et al.   GENOME RESEARCH

Genome-scale analysis of aberrant DNA methylation in colorectal cancer

(2011) T. Hinoue et al.   GENOME RESEARCH

Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria

(2011) Soumita Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

(2011) Alexandra Zhernakova et al.   PLoS Genetics

Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo

(2010) Michael R. Elliott et al.   NATURE

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An α-Helical Extension of the ELMO1 Pleckstrin Homology Domain Mediates Direct Interaction to DOCK180 and Is Critical in Rac Signaling

(2008) David Komander et al.   MOLECULAR BIOLOGY OF THE CELL