Circulating Free DNA and Its Emerging Role in Autoimmune Diseases

Biological variability of cell-free DNA in healthy females at rest within a short time course

(2020) Katrin Brodbeck et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Circulating unmethylated insulin DNA as a biomarker of human beta cell death: a multi-laboratory assay comparison

(2020) Cate Speake et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

(2020) Eva Gonçalves Serra et al.   Nature Communications

Treatment of severe sepsis with nanoparticulate cell-free DNA scavengers

(2020) Jianati Dawulieti et al.   Science Advances

Somatic Evolution in Non-neoplastic IBD-Affected Colon

(2020) Sigurgeir Olafsson et al.   CELL

Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)

(2020) Christian Rolfo et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Circulating tumor necrosis factor‐α DNA are elevated in psoriasis

(2020) Ryoko Sakamoto et al.   JOURNAL OF DERMATOLOGY

Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes

(2020) Pier Vitale Nuzzo et al.   NATURE MEDICINE

Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients

(2020) Svend Birkelund et al.   Clinical Proteomics

Identification of Specific Joint-Inflammatogenic Cell-Free DNA Molecules From Synovial Fluids of Patients With Rheumatoid Arthritis

(2020) Cong Dong et al.   Frontiers in Immunology

Circulating Cell-Free Nucleic Acids as Epigenetic Biomarkers in Precision Medicine

(2020) Beenish Rahat et al.   Frontiers in Genetics

Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application

(2020) Melinda Szilágyi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical and analytical validation of FoundationOne Liquid CDx, a novel 324-Gene cfDNA-based comprehensive genomic profiling assay for cancers of solid tumor origin

(2020) Ryan Woodhouse et al.   PLoS One

Immunoregulatory properties of cell-free DNA in plasma of celiac disease patients – A pilot study

(2019) Iva Brynychova et al.   AUTOIMMUNITY

Life and death of circulating cell-free DNA

(2019) Anatoli Kustanovich et al.   CANCER BIOLOGY & THERAPY

The relevance of pyroptosis in the pathogenesis of liver diseases

(2019) Huiting Guo et al.   LIFE SCIENCES

Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer

(2019) Fabrice André et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell-Free Nucleic Acids and their Emerging Role in the Pathogenesis and Clinical Management of Inflammatory Bowel Disease

(2019) Zuzana Kubiritova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analysis of polygenic risk score usage and performance in diverse human populations

(2019) L. Duncan et al.   Nature Communications

Pyroptosis: A new frontier in cancer

(2019) Yuan Fang et al.   BIOMEDICINE & PHARMACOTHERAPY

The diverse origins of circulating cell-free DNA in the human body: a critical re-evaluation of the literature

(2018) Janine Aucamp et al.   BIOLOGICAL REVIEWS

Circulating cell-free nucleic acids: characteristics and applications

(2018) Ondrej Pös et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases

(2018) Peter Celec et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD

(2018) Ray K Boyapati et al.   INFLAMMATORY BOWEL DISEASES

Systemic activation of NLRP3 inflammasome in patients with severe primary Sjögren's syndrome fueled by inflammagenic DNA accumulations

(2018) Aigli G. Vakrakou et al.   JOURNAL OF AUTOIMMUNITY

Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis

(2018) Nicolas Fissolo et al.   Multiple Sclerosis Journal

Anti-cytokine therapy and plasma DNA in patients with rheumatoid arthritis

(2018) Lucia Lauková et al.   RHEUMATOLOGY INTERNATIONAL

Liquid biopsies to guide therapeutic decisions in rheumatoid arthritis

(2018) Roxana Coras et al.   Translational Research

Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation

(2018) Boris L. Gala-Lopez et al.   TRANSPLANTATION

Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis

(2018) Nicolas Fissolo et al.   Multiple Sclerosis Journal

Review: Cell Death, Nucleic Acids, and Immunity

(2018) Keith B. Elkon   Arthritis & Rheumatology

Biomarkers in Islet Cell Transplantation for Type 1 Diabetes

(2018) Fatimah T. AlRashidi et al.   Current Diabetes Reports

High levels of circulating cell-free DNA are a biomarker of active SLE

(2018) Yalan Xu et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The Clinical Impact of Comprehensive Genomic Testing of Circulating Cell-Free DNA in Advanced Lung Cancer

(2018) Smadar Laufer-Geva et al.   Journal of Thoracic Oncology

Principles of DNA methylation and their implications for biology and medicine

(2018) Yuval Dor et al.   LANCET

Cell-free mitochondrial DNA in progressive multiple sclerosis

(2018) Hannah Lowes et al.   MITOCHONDRION

Sequencing of Circulating Cell-free DNA during Pregnancy

(2018) Diana W. Bianchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell-free DNA as a biomarker of aging

(2018) Yee Voan Teo et al.   AGING CELL

Cell-free DNA release under psychosocial and physical stress conditions

(2018) E. M. Hummel et al.   Translational Psychiatry

Profile of the Roche cobas® EGFR mutation test v2 for non-small cell lung cancer

(2017) Umberto Malapelle et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Increased levels of cell-free mitochondrial DNA in the cerebrospinal fluid of patients with multiple sclerosis

(2017) Kristin N. Varhaug et al.   MITOCHONDRION

Epi proColon® 2.0 CE: A Blood-Based Screening Test for Colorectal Cancer

(2017) Yvette N. Lamb et al.   Molecular Diagnosis & Therapy

LINE-1 Hypermethylation in Serum Cell-Free DNA of Relapsing Remitting Multiple Sclerosis Patients

(2017) Marina Dunaeva et al.   MOLECULAR NEUROBIOLOGY

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

(2017) Cyra E Leurs et al.   Multiple Sclerosis Journal

New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes

(2017) M. Rohan Fernando et al.   PLoS One

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

(2017) Cyra E Leurs et al.   Multiple Sclerosis Journal

Prediction and Prevention of Autoimmune Disease in the 21st Century: A Review and Preview

(2016) Noel R. Rose   AMERICAN JOURNAL OF EPIDEMIOLOGY

Origins, structures, and functions of circulating DNA in oncology

(2016) A. R. Thierry et al.   CANCER AND METASTASIS REVIEWS

Significant association of the KIR2DL3/HLA-C1 genotype with susceptibility to Crohn’s disease

(2016) Roberto Díaz-Peña et al.   HUMAN IMMUNOLOGY

Circulating cell free DNA: a marker to predict the therapeutic response for biological DMARDs in rheumatoid arthritis

(2016) Teppei Hashimoto et al.   International Journal of Rheumatic Diseases

Autoimmune diseases — connecting risk alleles with molecular traits of the immune system

(2016) Maria Gutierrez-Arcelus et al.   NATURE REVIEWS GENETICS

Identification of tissue-specific cell death using methylation patterns of circulating DNA

(2016) Roni Lehmann-Werman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

Genetic and genomic markers of anti-TNF treatment response in rheumatoid arthritis

(2015) James Oliver et al.   Biomarkers in Medicine

Excretion of Host DNA in Feces Is Associated with Risk ofClostridium difficileInfection

(2015) Caroline Vincent et al.   Journal of Immunology Research

The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE

(2014) David S. Pisetsky   AUTOIMMUNITY

Dynamic pathology for circulating free DNA in a dextran sodium sulfate colitis mouse model

(2014) Yuhki Koike et al.   PEDIATRIC SURGERY INTERNATIONAL

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

(2013) Yun Liu et al.   NATURE BIOTECHNOLOGY

Decrease in circulating DNA, IL-10 and BAFF levels in newly-diagnosed SLE patients after corticosteroid and chloroquine treatment

(2012) Alma-Martina Cepika et al.   CELLULAR IMMUNOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

The Inhibition of Anti-DNA Binding to DNA by Nucleic Acid Binding Polymers

(2012) Nancy A. Stearns et al.   PLoS One

TLR9 is important for protection against intestinal damage and for intestinal repair

(2012) William Alfred Rose II et al.   Scientific Reports

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

(2011) Hai Huang et al.   HEPATOLOGY

Increased levels of circulating DNA in patients with systemic autoimmune diseases: A possible marker of disease activity in Sjögren’s syndrome

(2011) E Bartoloni et al.   LUPUS

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Urinary Biomarkers in Lupus Nephritis

(2010) Joyce Reyes-Thomas et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Analysing cell-free plasma DNA and SLE disease activity

(2010) Johanna Atamaniuk et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis

(2010) Gabriel J. Tobón et al.   JOURNAL OF AUTOIMMUNITY

Serum DNA Motifs Predict Disease and Clinical Status in Multiple Sclerosis

(2010) Julia Beck et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Methylation patterns of cell-free plasma DNA in relapsing–remitting multiple sclerosis

(2010) Thomas Liggett et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Circulating levels of adiponectin, oxidized LDL and C-reactive protein in Portuguese patients with psoriasis vulgaris, according to body mass index, severity and duration of the disease

(2009) Susana Coimbra et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity

(2008) Yehuda Shoenfeld et al.   JOURNAL OF AUTOIMMUNITY

Pathogenic anti-nucleosome antibodies

(2008) S Muller et al.   LUPUS

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE