The genetics of rheumatoid arthritis

The association between NAT2 acetylator status and adverse drug reactions of sulfasalazine: a systematic review and meta-analysis

(2020) Jeong Yee et al.   Scientific Reports

Identification of rheumatoid arthritis causal genes using functional genomics

(2019) James Ding et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry

(2019) Elke Schaeffeler et al.   GENETICS IN MEDICINE

Benefits and limitations of genome-wide association studies

(2019) Vivian Tam et al.   NATURE REVIEWS GENETICS

Improved power and precision with whole genome sequencing data in genome-wide association studies of inflammatory biomarkers

(2019) Julia Höglund et al.   Scientific Reports

Linking of genetic risk variants to disease-specific gene expression via multi-omics studies in rheumatoid arthritis

(2019) Akari Suzuki et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Systematic approach demonstrates enrichment of multiple interactions between non-HLArisk variants andHLA-DRB1risk alleles in rheumatoid arthritis

(2018) Lina-Marcela Diaz-Gallo et al.   ANNALS OF THE RHEUMATIC DISEASES

From genome-wide associations to candidate causal variants by statistical fine-mapping

(2018) Daniel J. Schaid et al.   NATURE REVIEWS GENETICS

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

(2018) John C. Taylor et al.   PHARMACOGENOMICS JOURNAL

Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

(2018) Harm-Jan Westra et al.   NATURE GENETICS

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis

(2018) Jonathan Massey et al.   PHARMACOGENOMICS JOURNAL

Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis

(2017) Qi Qiu et al.   MEDICINE

Are gene polymorphisms related to treatment outcomes of methotrexate in patients with rheumatoid arthritis? A systematic review and meta-analysis

(2017) Yuehong Chen et al.   PHARMACOGENOMICS

Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia

(2017) Shu-Guang Liu et al.   Oncotarget

Contribution of a Non-classical HLA Gene, HLA-DOA , to the Risk of Rheumatoid Arthritis

(2016) Yukinori Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Meta-analysis revealsPTPN221858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population

(2016) Gowher Nabi et al.   AUTOIMMUNITY

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Genetic studies of rheumatoid arthritis

(2015) Kazuhiko YAMAMOTO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations

(2014) Yukinori Okada et al.   HUMAN MOLECULAR GENETICS

Association between tumor necrosis factor-α (TNF-α) promoter −308 G/A and response to TNF-α blockers in rheumatoid arthritis: a meta-analysis

(2014) Zhen Zeng et al.   Modern Rheumatology

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

(2014) Suk-Kyun Yang et al.   NATURE GENETICS

Pharmacogenomics of NAT2 and ABCG2 influence the toxicity and efficacy of sulphasalazine containing DMARD regimens in early rheumatoid arthritis

(2014) M D Wiese et al.   PHARMACOGENOMICS JOURNAL

Protective Effect of the HLA-DRB1*13:02 Allele in Japanese Rheumatoid Arthritis Patients

(2014) Shomi Oka et al.   PLoS One

Novel Risk Loci for Rheumatoid Arthritis in Han Chinese and Congruence With Risk Variants in Europeans

(2014) Lei Jiang et al.   Arthritis & Rheumatology

The 158VV Fcgamma receptor 3A genotype is associated with response to rituximab in rheumatoid arthritis: results of an Italian multicentre study

(2013) Luca Quartuccio et al.   ANNALS OF THE RHEUMATIC DISEASES

Brief Report: Identification ofBACH2andRAD51Bas Rheumatoid Arthritis Susceptibility Loci in a Meta-Analysis of Genome-Wide Data

(2013) Kate McAllister et al.   ARTHRITIS AND RHEUMATISM

Genetics of Rheumatoid Arthritis — A Comprehensive Review

(2013) Júlia Kurkó et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

SLC19A180G allele as a biomarker of methotrexate-related gastrointestinal toxicity in Portuguese rheumatoid arthritis patients

(2013) Aurea Lima et al.   PHARMACOGENOMICS

Fcγ receptor type IIIA polymorphism influences treatment outcomes in patients with rheumatoid arthritis treated with rituximab

(2012) A Ruyssen-Witrand et al.   ANNALS OF THE RHEUMATIC DISEASES

The interferon signature in autoimmune diseases

(2012) Lars Rönnblom et al.   CURRENT OPINION IN RHEUMATOLOGY

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Pharmacogenetic Polymorphisms Contributing to Toxicity Induced by Methotrexate in the Southern Spanish Population with Rheumatoid Arthritis

(2012) José Cristian Plaza-Plaza et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms

(2011) S A Owen et al.   PHARMACOGENOMICS JOURNAL

Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA

(2010) J. L. Nam et al.   ANNALS OF THE RHEUMATIC DISEASES

Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: A meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein

(2010) Diane van der Woude et al.   ARTHRITIS AND RHEUMATISM

Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci

(2010) Darren Plant et al.   ARTHRITIS AND RHEUMATISM

The contribution of H LA to rheumatoid arthritis

(2010) C. M. Deighton et al.   CLINICAL GENETICS

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study

(2010) C. K. Iannaccone et al.   RHEUMATOLOGY

Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis

(2009) H. Hayashi et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Specific interaction between genotype, smoking and autoimmunity to citrullinated α-enolase in the etiology of rheumatoid arthritis

(2009) Hiba Mahdi et al.   NATURE GENETICS

TNF-α −308 G/A polymorphism and responsiveness to TNF-α blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis

(2009) D D O'Rielly et al.   PHARMACOGENOMICS JOURNAL

Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate

(2009) Y. C. Lee et al.   RHEUMATOLOGY

Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies

(2009) C. Meune et al.   RHEUMATOLOGY

Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis

(2008) James R. Maxwell et al.   HUMAN MOLECULAR GENETICS

How to Interpret a Genome-wide Association Study

(2008) Thomas A. Pearson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Linkage disequilibrium — understanding the evolutionary past and mapping the medical future

(2008) Montgomery Slatkin   NATURE REVIEWS GENETICS