Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism

Astrocyte Function is Modified by Alzheimer's Disease-like Pathology in Aged Mice

(2017) Oliver Peters et al.   JOURNAL OF ALZHEIMERS DISEASE

Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

(2016) C Yi et al.   CELL DEATH AND DIFFERENTIATION

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

(2016) Nicholas L Weilinger et al.   NATURE NEUROSCIENCE

Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse

(2016) J.F. Oliveira da Cruz et al.   NEUROSCIENCE

Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival

(2015) Beatriz C. Avendaño et al.   GLIA

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

Hemichannels: New pathways for gliotransmitter release

(2015) T.D. Montero et al.   NEUROSCIENCE

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

(2015) Juan A. Orellana et al.   Frontiers in Cellular Neuroscience

WIN 55,212-2, Agonist of Cannabinoid Receptors, Prevents Amyloid β1-42 Effects on Astrocytes in Primary Culture

(2015) Diana Aguirre-Rueda et al.   PLoS One

The dual face of connexin-based astroglial Ca2+ communication: A key player in brain physiology and a prime target in pathology

(2014) Marijke De Bock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Rising stars: Modulation of brain functions by astroglial type-1 cannabinoid receptors

(2014) Mathilde Metna-Laurent et al.   GLIA

Astrocytes in endocannabinoid signalling

(2014) M. Navarrete et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Connexons and pannexons: newcomers in neurophysiology

(2014) Giselle Cheung et al.   Frontiers in Cellular Neuroscience

Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet

(2014) Juan A. Orellana et al.   Frontiers in Cellular Neuroscience

Hemichannels in neurodegenerative diseases: is there a link to pathology?

(2014) Megan Bosch et al.   Frontiers in Cellular Neuroscience

The pannexins: past and present

(2014) Stephen R. Bond et al.   Frontiers in Physiology

Loss of Calcium/Calmodulin-dependent Protein Kinase II Activity in Cortical Astrocytes Decreases Glutamate Uptake and Induces Neurotoxic Release of ATP

(2013) Nicole M. Ashpole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain

(2012) I. Carrero et al.   EXPERIMENTAL NEUROLOGY

Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+Oscillations by Providing a Bimodal Ca2+-dependent Ca2+Entry Pathway

(2012) Marijke De Bock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death

(2012) Kentaro Nishida et al.   JOURNAL OF NEUROCHEMISTRY

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes

(2012) Cendra Agulhon et al.   Frontiers in Pharmacology

Glial connexin expression and function in the context of Alzheimer's disease

(2011) Annette Koulakoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity

(2011) N. Karpuk et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

(2011) Joana Arbeloa et al.   NEUROBIOLOGY OF DISEASE

Targeting Pannexin1 Improves Seizure Outcome

(2011) Marcelo F. Santiago et al.   PLoS One

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

(2010) Raf Ponsaerts et al.   FASEB JOURNAL

Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas

(2010) Nephi Stella   GLIA

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

GLIA modulates synaptic transmission

(2009) Gertrudis Perea et al.   BRAIN RESEARCH REVIEWS

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

(2009) Roger G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments

(2009) Nicolas Froger et al.   JOURNAL OF NEUROCHEMISTRY

WIN55,212-2 Inhibits Production of CX3CL1 by Human Astrocytes: Involvement of p38 MAP Kinase

(2009) W. S. Sheng et al.   Journal of Neuroimmune Pharmacology

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

(2009) R. Iglesias et al.   JOURNAL OF NEUROSCIENCE

Changing perspectives regarding late-life dementia

(2009) Majid Fotuhi et al.   Nature Reviews Neurology

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

(2008) R. Iglesias et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation

Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus

(2008) R. J. Thompson et al.   SCIENCE