Astroglial Connexins in Neurodegenerative Diseases

Pannexin‐1 in the CNS: emerging concepts in health and disease

(2020) Albert K. Yeung et al.   JOURNAL OF NEUROCHEMISTRY

Glial connexins and pannexins in the healthy and diseased brain

(2020) Christian BA Giaume et al.   PHYSIOLOGICAL REVIEWS

Blood-brain barrier integrity in the pathogenesis of Alzheimer’s disease

(2020) Zhangsen Huang et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species

(2020) Juan C. Sáez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress

(2020) Melissa L. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β regulates gap junction protein Connexin 43 trafficking in cultured primary astrocytes

(2020) Mahua Maulik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glymphatic failure as a final common pathway to dementia

(2020) Maiken Nedergaard et al.   SCIENCE

Altered Expression of Glial Gap Junction Proteins Cx43, Cx30, and Cx47 in the 5XFAD Model of Alzheimer’s Disease

(2020) Stella Angeli et al.   Frontiers in Neuroscience

Astrocyte function from information processing to cognition and cognitive impairment

(2019) Mirko Santello et al.   NATURE NEUROSCIENCE

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke

(2019) Moises Freitas-Andrade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Connexin 43 hemichannels and pannexin‐1 channels contribute to the α‐synuclein‐induced dysfunction and death of astrocytes

(2019) Esteban F. Díaz et al.   GLIA

Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity

(2018) Layal Maatouk et al.   CELL DEATH AND DIFFERENTIATION

Cx43 Channel Gating and Permeation: Multiple Phosphorylation-Dependent Roles of the Carboxyl Terminus

(2018) José Ek-Vitorín et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Specific deletion connexin43 in astrocyte ameliorates cognitive dysfunction in APP/PS1 mice

(2018) Ren Runan et al.   LIFE SCIENCES

Amyotrophic Lateral Sclerosis: An Update for 2018

(2018) Björn Oskarsson et al.   MAYO CLINIC PROCEEDINGS

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy

(2018) Nefeli Slavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

(2018) Atsushi Fujita et al.   Journal of Neuroinflammation

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Connexin-43 Gap Junctions Are Responsible for the Hypothalamic Tanycyte-Coupled Network

(2018) Antonia Recabal et al.   Frontiers in Cellular Neuroscience

GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

(2018) Yuji Kajiwara et al.   Acta Neuropathologica Communications

Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease

(2017) Chenju Yi et al.   GLIA

Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex

(2017) Claire Meunier et al.   JOURNAL OF NEUROSCIENCE

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

(2017) Carolina Cunha et al.   MOLECULAR NEUROBIOLOGY

Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain

(2017) Marijke De Bock et al.   NEUROCHEMICAL RESEARCH

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle

(2017) Jerome Clasadonte et al.   NEURON

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

(2017) Michael G. Erkkinen et al.   Cold Spring Harbor Perspectives in Biology

Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

(2016) C Yi et al.   CELL DEATH AND DIFFERENTIATION

High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring

(2016) Carola J. Maturana et al.   Developmental Neurobiology

A structural and functional comparison of gap junction channels composed of connexins and innexins

(2016) I. Martha Skerrett et al.   Developmental Neurobiology

Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism

(2016) Rosario Gajardo-Gómez et al.   GLIA

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

(2016) Akshata A. Almad et al.   GLIA

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Defects in trafficking bridge Parkinson's disease pathology and genetics

(2016) Asa Abeliovich et al.   NATURE

Immune Quiescence of the Brain Is Set by Astroglial Connexin 43

(2015) A.-C. Boulay et al.   JOURNAL OF NEUROSCIENCE

Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection

(2015) Rainer Schulz et al.   PHARMACOLOGY & THERAPEUTICS

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

(2015) Juan A. Orellana et al.   Frontiers in Cellular Neuroscience

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Altered Inhibition of Cx26 Hemichannels by pH and Zn2+in the A40V Mutation Associated with Keratitis-Ichthyosis-Deafness Syndrome

(2014) Helmuth A. Sanchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord

(2014) David Bravo et al.   PAIN

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes

(2014) Verónica Abudara et al.   Frontiers in Cellular Neuroscience

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

(2014) Ricardo Cabezas et al.   Frontiers in Cellular Neuroscience

Pannexins form gap junctions with electrophysiological and pharmacological properties distinct from connexins

(2014) Giriraj Sahu et al.   Scientific Reports

Gap Junction Intercellular Communication Mediated by Connexin43 in Astrocytes Is Essential for Their Resistance to Oxidative Stress

(2013) Hoa T. Le et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gastrodin ameliorates Parkinson’s disease by downregulating connexin 43

(2013) YU WANG et al.   Molecular Medicine Reports

Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: Gap junctions versus hemichannels

(2013) Jegan Iyyathurai et al.   NEUROPHARMACOLOGY

Updates in the medical management of Parkinson disease

(2012) H. H. FERNANDEZ   CLEVELAND CLINIC JOURNAL OF MEDICINE

Deletion of Astroglial Connexins Weakens the Blood–Brain Barrier

(2012) Pascal Ezan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Manipulating Connexin Communication Channels: Use of Peptidomimetics and the Translational Outputs

(2012) W. Howard Evans et al.   JOURNAL OF MEMBRANE BIOLOGY

Critical Role of Connexin 43 in Secondary Expansion of Traumatic Spinal Cord Injury

(2012) C. Huang et al.   JOURNAL OF NEUROSCIENCE

Pannexin channels are not gap junction hemichannels

(2011) Gina E. Sosinsky et al.   Channels

Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic mice

(2011) J. I. Nagy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges

(2011) B. D. Lynn et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity

(2011) N. Karpuk et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease

(2011) Hideyuki Takeuchi et al.   PLoS One

Targeting Pannexin1 Improves Seizure Outcome

(2011) Marcelo F. Santiago et al.   PLoS One

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

(2011) P. Diaz-Amarilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astroglial networks scale synaptic activity and plasticity

(2011) U. Pannasch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasticity of astroglial networks in olfactory glomeruli

(2011) L. Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

(2010) Nicolas Froger et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

Functional significance of the negative-feedback regulation of ATP release via pannexin-1 hemichannels under ischemic stress in astrocytes

(2010) Sadahiro Iwabuchi et al.   NEUROCHEMISTRY INTERNATIONAL

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels

(2010) J. M. Garre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAT Peptide and Its Conjugates: Proteolytic Stability

(2009) Jacob Grunwald et al.   BIOCONJUGATE CHEMISTRY

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

(2009) Elke De Vuyst et al.   CELL CALCIUM

Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels

(2009) Juan A. Orellana et al.   GLIA

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

(2009) R. Iglesias et al.   JOURNAL OF NEUROSCIENCE

Modulation of connexin 43 in rotenone-induced model of Parkinson's disease

(2009) A. Kawasaki et al.   NEUROSCIENCE

Different properties of P2X7 receptor in hippocampal and cortical astrocytes

(2009) Fabio Bianco et al.   Purinergic Signalling

Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

(2008) Juan A. Orellana et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential modulation of unapposed connexin 43 hemichannel electrical conductance by protein kinase C isoforms

(2008) G. Hawat et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE