Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

Astrocyte Function is Modified by Alzheimer's Disease-like Pathology in Aged Mice

(2017) Oliver Peters et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

P2Y receptors in Alzheimer's disease

(2014) Laurie Erb et al.   BIOLOGY OF THE CELL

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease

(2013) Elena Alberdi et al.   AGING CELL

A Key Role for Connexin Hemichannels in Spreading Ischemic Brain Injury

(2013) Joanne O. Davidson et al.   CURRENT DRUG TARGETS

Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage

(2013) Daniela Durand et al.   NEUROPHARMACOLOGY

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

(2013) Christian Giaume et al.   Frontiers in Pharmacology

Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+Oscillations by Providing a Bimodal Ca2+-dependent Ca2+Entry Pathway

(2012) Marijke De Bock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer's Disease Model Mice

(2012) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Aβ leads to Ca2+ signaling alterations and transcriptional changes in glial cells

(2012) Ambra A. Grolla et al.   NEUROBIOLOGY OF AGING

Glial hemichannels and their involvement in aging and neurodegenerative diseases

(2012) Juan A. Orellana et al.   REVIEWS IN THE NEUROSCIENCES

Glial connexin expression and function in the context of Alzheimer's disease

(2011) Annette Koulakoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex

(2011) Pascal Fossat et al.   CEREBRAL CORTEX

Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

(2011) Sebastian Jimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity

(2011) N. Karpuk et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Astrocytic Gap Junctional Communication is Reduced in Amyloid-β-Treated Cultured Astrocytes, but not in Alzheimer's Disease Transgenic Mice

(2010) Nancy F Cruz et al.   ASN Neuro

The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein

(2010) Cécile Delarasse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

(2010) Nicolas Froger et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

(2009) Elke De Vuyst et al.   CELL CALCIUM

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Occurrence of Aging-Dependent Reticulon 3 Immunoreactive Dystrophic Neurites Decreases Cognitive Function

(2009) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

(2009) R. Iglesias et al.   JOURNAL OF NEUROSCIENCE

The P2X7 receptor–pannexin connection to dye uptake and IL-1β release

(2009) Pablo Pelegrin et al.   Purinergic Signalling

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Non-junction functions of pannexin-1 channels

(2009) Brian A. MacVicar et al.   TRENDS IN NEUROSCIENCES

Minocycline and neurodegenerative diseases

(2008) Hye-Sun Kim et al.   BEHAVIOURAL BRAIN RESEARCH

P2Y1receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL-6 release in hippocampal cultures

(2008) Takumi Fujita et al.   GLIA

Stimulated Efflux of Amino Acids and Glutathione from Cultured Hippocampal Slices by Omission of Extracellular Calcium

(2008) Malin H. Stridh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE

Drawing conclusions

(2008) Jenny Meyer   NATURE

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE