The role of glial-specific Kir4.1 in normal and pathological states of the CNS

Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease

(2015) Heather R. Minkel et al.   GLIA

Gap junction coupling confers isopotentiality on astrocyte syncytium

(2015) Baofeng Ma et al.   GLIA

New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling

(2015) M. L. Olsen et al.   JOURNAL OF NEUROSCIENCE

Group I metabotropic glutamate receptor agonist DHPG modulates Kir4.1 protein and mRNA in cultured rat retinal Müller cells

(2015) Feng Gao et al.   NEUROSCIENCE LETTERS

Kir4.1-mediated spatial buffering of K+: Experimental challenges in determination of its temporal and quantitative contribution to K+clearance in the brain

(2014) Brian Roland Larsen et al.   Channels

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

DNA methylation functions as a critical regulator of Kir4.1 expression during CNS development

(2014) Sinifunanya E. Nwaobi et al.   GLIA

Contribution of KCNJ10 Gene Polymorphisms in Childhood Epilepsy

(2014) Alper I. Dai et al.   JOURNAL OF CHILD NEUROLOGY

A HomozygousKCNJ10Mutation in Jack Russell Terriers and Related Breeds with Spinocerebellar Ataxia with Myokymia, Seizures, or Both

(2014) D. Gilliam et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study

(2014) Adipong Brickshawana et al.   LANCET NEUROLOGY

Lack of confirmation of anti-inward rectifying potassium channel 4.1 antibodies as reliable markers of multiple sclerosis

(2014) Elodie Nerrant et al.   Multiple Sclerosis Journal

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

Dual patch voltage clamp study of low membrane resistance astrocytes in situ

(2014) Baofeng Ma et al.   Molecular Brain

Generation and validation of a zebrafish model of EAST (epilepsy, ataxia, sensorineural deafness and tubulopathy) syndrome

(2013) F. Mahmood et al.   Disease Models & Mechanisms

Expression of Aquaporin 4 and Kir4.1 in Diabetic Rat Retina: Treatment with Minocycline

(2013) Y Zhang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Oligodendrocyte Precursor Cells Are Accurate Sensors of Local K+ in Mature Gray Matter

(2013) P. P. Maldonado et al.   JOURNAL OF NEUROSCIENCE

Astroglial potassium clearance contributes to short-term plasticity of synaptically evoked currents at the tripartite synapse

(2013) Jérémie Sibille et al.   JOURNAL OF PHYSIOLOGY-LONDON

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation

(2012) Esther Steiner et al.   GLIA

Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1G93Arat model

(2012) Danijela Bataveljić et al.   GLIA

Relationship between glial potassium regulation and axon excitability: A role for glial Kir4.1 channels

(2012) Virginia Bay et al.   GLIA

Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β

(2012) Emanuele Zurolo et al.   Journal of Neuroinflammation

Group I mGluR-Mediated Inhibition of Kir Channels Contributes to Retinal Muller Cell Gliosis in a Rat Chronic Ocular Hypertension Model

(2012) M. Ji et al.   JOURNAL OF NEUROSCIENCE

Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis

(2012) Rajneesh Srivastava et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human kir4.1 gene (KCNJ10)

(2011) Nadia Nabil Haj-Yasein et al.   GLIA

Altered electroretinograms in patients with KCNJ10 mutations and EAST syndrome

(2011) Dorothy A. Thompson et al.   JOURNAL OF PHYSIOLOGY-LONDON

A role for glia in the progression of Rett’s syndrome

(2011) Daniel T. Lioy et al.   NATURE

Autism with Seizures and Intellectual Disability: Possible Causative Role of Gain-of-function of the Inwardly-Rectifying K+ Channel Kir4.1

(2011) Federico Sicca et al.   NEUROBIOLOGY OF DISEASE

Peripheral inflammation suppresses inward rectifying potassium currents of satellite glial cells in the trigeminal ganglia

(2011) Mamoru Takeda et al.   PAIN

Genetic Deletion of Laminin Isoforms β2 and γ3 Induces a Reduction in Kir4.1 and Aquaporin-4 Expression and Function in the Retina

(2011) Petra G. Hirrlinger et al.   PLoS One

Variable loss of Kir4.1 channel function in SeSAME syndrome mutations

(2010) Xiaofang Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spinal cord injury causes a wide-spread, persistent loss of Kir4.1 and glutamate transporter 1: benefit of 17 -oestradiol treatment

(2010) M. L. Olsen et al.   BRAIN

Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice

(2010) Mikhail Inyushin et al.   EPILEPSIA

Molecular Mechanisms of EAST/SeSAME Syndrome Mutations in Kir4.1 (KCNJ10)

(2010) Monica Sala-Rabanal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Dysfunction of Astrocytic Inwardly Rectifying K+ Channels Specific to the Neocortical Epileptic Focus After Fluid Percussion Injury in the Rat

(2010) Tessandra H. Stewart et al.   JOURNAL OF NEUROPHYSIOLOGY

Astrocytes in the Retrotrapezoid Nucleus Sense H+ by Inhibition of a Kir4.1–Kir5.1-Like Current and May Contribute to Chemoreception by a Purinergic Mechanism

(2010) Ian C. Wenker et al.   JOURNAL OF NEUROPHYSIOLOGY

Implication of Kir4.1 Channel in Excess Potassium Clearance: An In Vivo Study on Anesthetized Glial-Conditional Kir4.1 Knock-Out Mice

(2010) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Molecular Basis of Decreased Kir4.1 Function in SeSAME/EAST Syndrome

(2010) D. M. Williams et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impact of global cerebral ischemia on K+ channel expression and membrane properties of glial cells in the rat hippocampus

(2010) Helena Pivonkova et al.   NEUROCHEMISTRY INTERNATIONAL

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function

(2010) M. Reichold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP, glia and central respiratory control

(2010) Joseph S. Erlichman et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis

(2009) Xiaofang Tang et al.   GLIA

Linkage and linkage disequilibrium scan for autism loci in an extended pedigree from Finland

(2009) Helena Kilpinen et al.   HUMAN MOLECULAR GENETICS

Analysis of Astroglial K+ Channel Expression in the Developing Hippocampus Reveals a Predominant Role of the Kir4.1 Subunit

(2009) G. Seifert et al.   JOURNAL OF NEUROSCIENCE

Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters

(2009) Ana María Estrada-Sánchez et al.   NEUROBIOLOGY OF DISEASE

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

Epilepsy, Ataxia, Sensorineural Deafness, Tubulopathy, andKCNJ10Mutations

(2009) Detlef Bockenhauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10

(2009) U. I. Scholl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult-onset Alexander disease: a series of eleven unrelated cases with review of the literature

(2008) D. Pareyson et al.   BRAIN

Functional implications for Kir4.1 channels in glial biology: from K+buffering to cell differentiation

(2008) Michelle L. Olsen et al.   JOURNAL OF NEUROCHEMISTRY

Silencing the Kir4.1 Potassium Channel Subunit in Satellite Glial Cells of the Rat Trigeminal Ganglion Results in Pain-Like Behavior in the Absence of Nerve Injury

(2008) J.-P. Vit et al.   JOURNAL OF NEUROSCIENCE

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

(2008) B.R. Miller et al.   NEUROSCIENCE

Proliferative gliosis causes mislocation and inactivation of inwardly rectifying K+ (Kir) channels in rabbit retinal glial cells

(2007) Elke Ulbricht et al.   EXPERIMENTAL EYE RESEARCH