GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

Specific deletion connexin43 in astrocyte ameliorates cognitive dysfunction in APP/PS1 mice

(2018) Ren Runan et al.   LIFE SCIENCES

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures

(2018) Andrew T. McKenzie et al.   Scientific Reports

Slow Excitotoxicity in Alzheimer's Disease

(2018) Wei-Yi Ong et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease

(2017) Chenju Yi et al.   GLIA

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

variancePartition: interpreting drivers of variation in complex gene expression studies

(2016) Gabriel E. Hoffman et al.   BMC BIOINFORMATICS

Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

(2016) C Yi et al.   CELL DEATH AND DIFFERENTIATION

The human-specificCASP4gene product contributes to Alzheimer-related synaptic and behavioural deficits

(2016) Yuji Kajiwara et al.   HUMAN MOLECULAR GENETICS

Alzheimer disease: modeling an Aβ-centered biological network

(2016) D Campion et al.   MOLECULAR PSYCHIATRY

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

(2016) Minghui Wang et al.   Genome Medicine

Convergent genetic and expression data implicate immunity in Alzheimer's disease

(2015) Lesley Jones et al.   Alzheimers & Dementia

Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms

(2015) Julien Bruban et al.   FASEB JOURNAL

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

(2015) Neelroop N. Parikshak et al.   NATURE REVIEWS GENETICS

Early changes in extracellular matrix in Alzheimer's disease

(2015) F.-X. Lepelletier et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Syndromic and non-syndromic disease-linked Cx43 mutations

(2014) Dale W. Laird   FEBS LETTERS

Differentiating connexin hemichannels and pannexin channels in cellular ATP release

(2014) Alexander W. Lohman et al.   FEBS LETTERS

Astroglial Connexin43 Hemichannels Tune Basal Excitatory Synaptic Transmission

(2014) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond

(2014) Catheleyne D'hondt et al.   Frontiers in Physiology

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study

(2013) Masaaki Hokama et al.   CEREBRAL CORTEX

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

(2013) Zaira Esposito et al.   CNS Neuroscience & Therapeutics

Overview and Findings from the Religious Orders Study

(2013) David A. Bennett et al.   Current Alzheimer Research

Astrocyte-restricted disruption of connexin-43 impairs neuronal plasticity in mouse barrel cortex

(2013) Yong Han et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gap Junction Intercellular Communication Mediated by Connexin43 in Astrocytes Is Essential for Their Resistance to Oxidative Stress

(2013) Hoa T. Le et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Genes and pathways underlying regional and cell type changes in Alzheimer's disease

(2013) Jeremy A Miller et al.   Genome Medicine

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

(2012) I.-M. Wang et al.   Molecular Systems Biology

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Role of Gap Junction Protein Connexin43 in Astrogliosis Induced by Brain Injury

(2012) Nicolas Theodoric et al.   PLoS One

Glial connexin expression and function in the context of Alzheimer's disease

(2011) Annette Koulakoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Astroglial networks scale synaptic activity and plasticity

(2011) U. Pannasch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease

(2010) Yakeel T. Quiroz et al.   ANNALS OF NEUROLOGY

Astrocytic Aβ1-42 uptake is determined by Aβ-aggregation state and the presence of amyloid-associated proteins

(2010) Henrietta M. Nielsen et al.   GLIA

The Connexin43 C-Terminal Region Mediates Neuroprotection During Stroke

(2010) Michael G. Kozoriz et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Disentangling molecular relationships with a causal inference test

(2009) Joshua Millstein et al.   BMC GENETICS

Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation

(2009) S. E. Lutz et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Cytoskeletal pathologies of Alzheimer disease

(2009) James R. Bamburg et al.   CELL MOTILITY AND THE CYTOSKELETON

Pharmacological “cross-inhibition” of connexin hemichannels and swelling activated anion channels

(2008) Zu-Cheng Ye et al.   GLIA

A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

(2008) J. A. Miller et al.   JOURNAL OF NEUROSCIENCE

A Central Role of Connexin 43 in Hypoxic Preconditioning

(2008) J. H.-C. Lin et al.   JOURNAL OF NEUROSCIENCE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear

(2008) F. Anselmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia

(2007) Vahram Haroutunian et al.   NEUROBIOLOGY OF AGING