Autophagy and tumorigenesis

The pleiotropic functions of autophagy in metastasis

(2021) Timothy Marsh et al.   JOURNAL OF CELL SCIENCE

Beyond Autophagy: The Expanding Roles of ATG8 Proteins

(2021) Jose L. Nieto-Torres et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy and Cancer Dormancy

(2021) Yunus Akkoc et al.   Frontiers in Oncology

LC3C mediates selective autophagy of the MET RTK, inhibiting cancer cell invasion

(2020) Emily S. Bell et al.   Autophagy

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

(2020) Timothy Marsh et al.   DEVELOPMENTAL CELL

Intestinal Alkaline Phosphatase Exerts Anti-Inflammatory Effects Against Lipopolysaccharide by Inducing Autophagy

(2020) Sudha B. Singh et al.   Scientific Reports

Autophagy suppresses breast cancer metastasis by degrading NBR1

(2020) Timothy Marsh et al.   Autophagy

The Frequency of Ras Mutations in Cancer

(2020) Ian A. Prior et al.   CANCER RESEARCH

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

FIP200 suppresses immune checkpoint therapy responses in breast cancers by limiting AZI2/TBK1/IRF signaling independent of its canonical autophagy function

(2020) Takako Okamoto et al.   CANCER RESEARCH

Autophagy Roles in Genome Maintenance

(2020) Susanna Ambrosio et al.   Cancers

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

(2020) Keith A. Lawson et al.   NATURE

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells

(2020) Jaya Bhushan et al.   mBio

Targeting autophagy to overcome drug resistance: further developments

(2020) Haocai Chang et al.   Journal of Hematology & Oncology

Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

(2020) Khoosheh Khayati et al.   eLife

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Autophagy inhibition to augment mTOR inhibition: A phase I/II trial of everolimus and hydroxychloroquine in patients with previously treated renal cell carcinoma

(2019) Naomi B. Haas et al.   CLINICAL CANCER RESEARCH

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

(2019) Chih-Shia Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

(2019) Kirsten L. Bryant et al.   NATURE MEDICINE

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis

(2019) Vrushank Bhatt et al.   GENES & DEVELOPMENT

Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation

(2019) Nina Germic et al.   CELL DEATH AND DIFFERENTIATION

Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells

(2019) Dong Sun Oh et al.   Autophagy

Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?

(2019) Yoshihiro Ohue et al.   CANCER SCIENCE

Emerging Principles of Selective ER Autophagy

(2019) Simon Wilkinson   JOURNAL OF MOLECULAR BIOLOGY

Anticancer autophagy inhibitors attract ‘resurgent’ interest

(2019) Elie Dolgin   NATURE REVIEWS DRUG DISCOVERY

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

(2019) Lindsay DeVorkin et al.   Cell Reports

Role of tumor and host autophagy in cancer metabolism

(2019) Laura Poillet-Perez et al.   GENES & DEVELOPMENT

Targeting mTOR for cancer therapy

(2019) Hui Hua et al.   Journal of Hematology & Oncology

Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

(2019) Junghyun Lim et al.   eLife

Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response

(2019) Faustino Mollinedo et al.   Annals of Translational Medicine

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Autophagy: A novel mechanism of chemoresistance in cancers

(2019) Xinyu Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

(2019) Søs Grønbæk Holdgaard et al.   Nature Communications

Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization

(2019) Marta Pérez-Hernández et al.   Cancers

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer

(2019) Braicu et al.   Cancers

LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion

(2019) Emily S. Bell et al.   Cell Reports

Functions of autophagy in the tumor microenvironment and cancer metastasis

(2018) Erin E. Mowers et al.   FEBS Journal

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms

(2018) Annan Yang et al.   Cancer Discovery

STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarcinoma

(2018) Ferdinandos Skoulidis et al.   Cancer Discovery

ATG5 is required for B cell polarization and presentation of particulate antigens

(2018) Florent Arbogast et al.   Autophagy

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

(2018) Larissa D. Cunha et al.   CELL

Autophagy maintains tumour growth through circulating arginine

(2018) Laura Poillet-Perez et al.   NATURE

Macropinocytosis and autophagy crosstalk in nutrient scavenging

(2018) Oliver Florey et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma

(2017) Emma C. Scott et al.   HAEMATOLOGICA

Autophagy Roles in the Modulation of DNA Repair Pathways

(2017) Luciana Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LC3-Associated Phagocytosis and Inflammation

(2017) Bradlee L. Heckmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Microenvironmental autophagy promotes tumour growth

(2017) Nadja S. Katheder et al.   NATURE

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways

(2017) Fang Tang et al.   ONCOLOGY REPORTS

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

(2017) Andrew M. Waters et al.   Cold Spring Harbor Perspectives in Medicine

Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma

(2017) Emma C. Scott et al.   HAEMATOLOGICA

Autophagy-dependent regulation of tumor metastasis by myeloid cells

(2017) Masahisa Jinushi et al.   PLoS One

Revisiting autophagy addiction of tumor cells

(2016) Beat Nyfeler et al.   Autophagy

Autophagy induction for the treatment of cancer

(2016) Federico Pietrocola et al.   Autophagy

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Atg7cooperates withPtenloss to drive prostate cancer tumor growth

(2016) Urmila Santanam et al.   GENES & DEVELOPMENT

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication

(2016) Mario Mauthe et al.   JOURNAL OF CELL BIOLOGY

At the crossroads of autophagy and infection: Noncanonical roles for ATG proteins in viral replication

(2016) Tina Solvik et al.   JOURNAL OF CELL BIOLOGY

Autophagy inhibition upregulates CD4+ tumor infiltrating lymphocyte expression via miR-155 regulation and TRAIL activation

(2016) Paul Zarogoulidis et al.   Molecular Oncology

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

Autophagy in cancer metastasis

(2016) E E Mowers et al.   ONCOGENE

Autophagy and p53

(2016) Eileen White   Cold Spring Harbor Perspectives in Medicine

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

DNA Damage Response and Autophagy: A Meaningful Partnership

(2016) Aristides G. Eliopoulos et al.   Frontiers in Genetics

The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

(2015) Sandrine Obba et al.   Autophagy

Cross-cancer profiling of molecular alterations within the human autophagy interaction network

(2015) Chandra B Lebovitz et al.   Autophagy

Untangling knots between autophagic targets and candidate drugs, in cancer therapy

(2015) Tao Xie et al.   CELL PROLIFERATION

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

The non-canonical role of Atg family members as suppressors of innate antiviral immune signaling

(2014) Fumihiko Takeshita et al.   Autophagy

Combined MTOR and autophagy inhibition

(2014) Reshma Rangwala et al.   Autophagy

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

(2014) Xiao-Hong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

(2014) Saurabh V. Laddha et al.   MOLECULAR CANCER RESEARCH

Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity

(2014) Robin Mathew et al.   MOLECULAR CELL

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Autophagy supports genomic stability by degrading retrotransposon RNA

(2014) Huishan Guo et al.   Nature Communications

Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-Driven Cancers

(2014) A. M. Strohecker et al.   Cancer Discovery

Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors

(2014) J. M. M. Levy et al.   Cancer Discovery

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

(2013) A. Belaid et al.   CANCER RESEARCH

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

(2013) Jun Li et al.   CARCINOGENESIS

Mitochondrial Dysfunction Indirectly Elevates ROS Production by the Endoplasmic Reticulum

(2013) Michael P. Murphy   Cell Metabolism

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Mitochondrial Autophagy

(2013) Robert L. Thomas et al.   CIRCULATION JOURNAL

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance

(2013) Muhammad Baghdadi et al.   IMMUNITY

The Mechanism and Physiological Function of Macroautophagy

(2013) Daniel J. Klionsky et al.   Journal of Innate Immunity

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

(2013) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer

(2013) Y. Huo et al.   Cancer Discovery

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells

(2012) Enrico Desideri et al.   Autophagy

Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions

(2012) A. Jacquel et al.   BLOOD

Induction of autophagy is essential for monocyte-macrophage differentiation

(2012) Y. Zhang et al.   BLOOD

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

(2012) Lin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

(2012) Jill Henault et al.   IMMUNITY

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma

(2012) Eric A. Collisson et al.   Cancer Discovery

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome

(2011) R. Lazova et al.   CLINICAL CANCER RESEARCH

Tumor-Derived Autophagosome Vaccine: Induction of Cross-Protective Immune Responses against Short-lived Proteins through a p62-Dependent Mechanism

(2011) C. G. Twitty et al.   CLINICAL CANCER RESEARCH

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

(2011) Seth A. Wander et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Role of autophagy in suppression of inflammation and cancer

(2010) Eileen White et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Autophagy and Its Role in MHC-Mediated Antigen Presentation

(2009) V. L. Crotzer et al.   JOURNAL OF IMMUNOLOGY

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

(2008) Claudine Kraft et al.   NATURE CELL BIOLOGY