Autophagy in cancer metastasis

The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer

(2016) Sylvain Ladoire et al.   Autophagy

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

(2016) Zhenyu Zhong et al.   CELL

Uncoordinated 51-like kinase 2 signaling pathway regulates epithelial-mesenchymal transition in A549 lung cancer cells

(2016) Young Hwan Kim et al.   FEBS LETTERS

Atg7cooperates withPtenloss to drive prostate cancer tumor growth

(2016) Urmila Santanam et al.   GENES & DEVELOPMENT

Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model

(2016) Song Chen et al.   GENES & DEVELOPMENT

NBR1 enables autophagy-dependent focal adhesion turnover

(2016) Candia M. Kenific et al.   JOURNAL OF CELL BIOLOGY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death

(2016) F S Salah et al.   Cell Death & Disease

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

(2016) Marina N. Sharifi et al.   Cell Reports

Evolutionary trends and functional anatomy of the human expanded autophagy network

(2015) Andreas Till et al.   Autophagy

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing

(2015) Andrés Tittarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells

(2015) Myriam Catalano et al.   Molecular Oncology

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

(2015) Pui-Mun Wong et al.   Nature Communications

Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma

(2015) X. Xie et al.   Cancer Discovery

Instructive Roles of Extracellular Matrix on Autophagy

(2014) Thomas Neill et al.   AMERICAN JOURNAL OF PATHOLOGY

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Genetic interactions betweenDrosophila melanogasterAtg1 and paxillin reveal a role for paxillin in autophagosome formation

(2014) Guang-Chao Chen et al.   Autophagy

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

ITPR1 Protects Renal Cancer Cells against Natural Killer Cells by Inducing Autophagy

(2014) Y. Messai et al.   CANCER RESEARCH

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors

(2014) Matthieu Bertrand et al.   CELL CYCLE

ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7

(2014) Z Lu et al.   CELL DEATH AND DIFFERENTIATION

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

(2014) Sandra S. McAllister et al.   NATURE CELL BIOLOGY

Regulation of cell proliferation and migration by p62 through stabilization of Twist1

(2014) L. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion

(2014) R. Lock et al.   Cancer Discovery

Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness

(2014) Francesc Baixauli et al.   Frontiers in Immunology

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

(2013) Nan Chen et al.   Autophagy

Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells

(2013) Yuan-Fei Peng et al.   Autophagy

The pre-metastatic niche: finding common ground

(2013) Jaclyn Sceneay et al.   CANCER AND METASTASIS REVIEWS

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell-Mediated Lysis

(2013) I. Akalay et al.   CANCER RESEARCH

Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

(2013) A. Belaid et al.   CANCER RESEARCH

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

(2013) Jun Li et al.   CARCINOGENESIS

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy

(2013) Bernadette Carroll et al.   DEVELOPMENTAL CELL

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy and Cellular Immune Responses

(2013) Yuting Ma et al.   IMMUNITY

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

(2013) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

Secretory versus Degradative Autophagy: Unconventional Secretion of Inflammatory Mediators

(2013) Shanya Jiang et al.   Journal of Innate Immunity

Tumour suppressor gene function in carcinoma-associated fibroblasts: from tumour cells via EMT and back again?

(2013) Lauren E Drake et al.   JOURNAL OF PATHOLOGY

High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer

(2013) Hong Zhao et al.   MEDICAL ONCOLOGY

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation

(2013) M Roh-Johnson et al.   ONCOGENE

Promoting Colonization in Metastatic HCC Cells by Modulation of Autophagy

(2013) Yuan-Fei Peng et al.   PLoS One

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

(2013) J. Baginska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress

(2013) Aditi U. Gurkar et al.   Nature Communications

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells

(2012) Patricia Vázquez et al.   Autophagy

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Inhibition of autophagy impairs tumor cell invasion in an organotypic model

(2012) Robin L. Macintosh et al.   CELL CYCLE

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production

(2012) Claudia Capparelli et al.   CELL CYCLE

Regulation of autophagosome formation by Rho kinase

(2012) Andrzej Mleczak et al.   CELLULAR SIGNALLING

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagy Promotes Intracellular Degradation of Type I Collagen Induced by Transforming Growth Factor (TGF)-β1

(2012) Sung Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells

(2012) S Galavotti et al.   ONCOGENE

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

(2012) A Avivar-Valderas et al.   ONCOGENE

Basal Autophagy Decreased During the Differentiation of Human Adult Mesenchymal Stem Cells

(2012) Lisa Oliver et al.   STEM CELLS AND DEVELOPMENT

Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

(2012) Vojo Deretic et al.   TRENDS IN CELL BIOLOGY

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

(2011) Antje S. Löffler et al.   Autophagy

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

(2011) M. Z. Noman et al.   CANCER RESEARCH

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

(2011) C. Grange et al.   CANCER RESEARCH

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

(2011) Dolores Di Vizio et al.   CELL CYCLE

Autophagy positively regulates the CD44+CD24-/lowbreast cancer stem-like phenotype

(2011) Sílvia Cufí et al.   CELL CYCLE

The diverse roles of Rac signaling in tumorigenesis

(2011) Natalie A. Mack et al.   CELL CYCLE

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome

(2011) R. Lazova et al.   CLINICAL CANCER RESEARCH

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs

(2011) Robert R. Langley et al.   INTERNATIONAL JOURNAL OF CANCER

Overcoming anoikis - pathways to anchorage-independent growth in cancer

(2011) M. C. Guadamillas et al.   JOURNAL OF CELL SCIENCE

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

(2011) Emma Sandilands et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Evidence for Epithelial-Mesenchymal Transition in Cancer Stem Cells of Head and Neck Squamous Cell Carcinoma

(2011) Chao Chen et al.   PLoS One

Autophagy in Human Embryonic Stem Cells

(2011) Thien Tra et al.   PLoS One

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Overexpression of Microtubule-Associated Protein-1 Light Chain 3 Is Associated with Melanoma Metastasis and Vasculogenic Mimicry

(2011) Chunrong Han et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer

(2010) Roberta Pang et al.   Cell Stem Cell

Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation

(2010) Marieke A.M. Frasa et al.   CURRENT BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation

(2010) Atsushi Nakano et al.   NATURE CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Malignant Precursor Cells Pre-Exist in Human Breast DCIS and Require Autophagy for Survival

(2010) Virginia Espina et al.   PLoS One

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment

(2010) P. Kadandale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)

(2010) A. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Autophagy Is Activated by TGF-  and Potentiates TGF- -Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells

(2009) K. Kiyono et al.   CANCER RESEARCH

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Autophagy and metastasis: another double-edged sword

(2009) Candia M Kenific et al.   CURRENT OPINION IN CELL BIOLOGY

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

Micrometastatic disease and metastatic outgrowth: clinical issues and experimental approaches

(2009) Patricia M McGowan et al.   Future Oncology

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in cutaneous malignant melanoma

(2009) Rossitza Lazova et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

(2008) A. Apel et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

The actin cytoskeleton in cancer cell motility

(2008) Michael F. Olson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Extracellular matrix regulation of autophagy

(2008) Rebecca Lock et al.   CURRENT OPINION IN CELL BIOLOGY

Migratory neighbors and distant invaders: tumor-associated niche cells

(2008) J. Wels et al.   GENES & DEVELOPMENT

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL