Lipid metabolic reprogramming in cancer cells

Alkylphospholipids – A Promising Class of Chemotherapeutic Agents with a Broad Pharmacological Spectrum

(2016) Juliana De Almeida Pachioni et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

The role of lipid droplets and adipocytes in cancer. Raman imaging of cell cultures: MCF10A, MCF7, and MDA-MB-231 compared to adipocytes in cancerous human breast tissue

(2015) Halina Abramczyk et al.   ANALYST

Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells

(2015) Samir F. El-Mashtoly et al.   ANALYTICAL CHEMISTRY

Cholesterol homeostasis and autophagic flux in perifosine-treated human hepatoblastoma HepG2 and glioblastoma U-87 MG cell lines

(2015) Pablo Ríos-Marco et al.   BIOCHEMICAL PHARMACOLOGY

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

(2015) M. R. Ricciardi et al.   BLOOD

Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study

(2015) David de Gonzalo-Calvo et al.   BMC CANCER

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

(2015) Colin A. Flaveny et al.   CANCER CELL

Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry

(2015) S. Guenther et al.   CANCER RESEARCH

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

Uncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer

(2015) Fabiola Bovenga et al.   Cell Metabolism

Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer

(2015) L. Zhang et al.   CLINICAL CANCER RESEARCH

Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells

(2015) Silviu Sbiera et al.   ENDOCRINOLOGY

Saturated and mono-unsaturated lysophosphatidylcholine metabolism in tumour cells: a potential therapeutic target for preventing metastases

(2015) Anna Raynor et al.   Lipids in Health and Disease

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism

(2015) Emelyn H. Shroff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

(2015) Fabienne Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenes strike a balance between cellular growth and homeostasis

(2015) Bo Qiu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

HIF2 -Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

(2015) B. Qiu et al.   Cancer Discovery

ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients

(2015) Teodoro Vargas et al.   Oncotarget

The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination

(2015) Federica Maione et al.   Scientific Reports

Nelfinavir and Nelfinavir Analogs Block Site-2 Protease Cleavage to Inhibit Castration-Resistant Prostate Cancer

(2015) Min Guan et al.   Scientific Reports

Stress Responses from the Endoplasmic Reticulum in Cancer

(2015) Hironori Kato et al.   Frontiers in Oncology

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models

(2014) Sun-Hee Kim et al.   INVESTIGATIONAL NEW DRUGS

Aspirin and COX-2 Inhibitor Use in Patients With Stage III Colon Cancer

(2014) Kimmie Ng et al.   JNCI-Journal of the National Cancer Institute

Cholesterol depletion by methyl-β-cyclodextrin augments tamoxifen induced cell death by enhancing its uptake in melanoma

(2014) Naoshad Mohammad et al.   Molecular Cancer

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

(2014) Antonina V. Kurtova et al.   NATURE

Novel prospects of statins as therapeutic agents in cancer

(2014) Simona Pisanti et al.   PHARMACOLOGICAL RESEARCH

Cancer Cells Differentially Activate and Thrive on De Novo Lipid Synthesis Pathways in a Low-Lipid Environment

(2014) Veerle W. Daniëls et al.   PLoS One

Alteration of the lipid profile in lymphomas induced by MYC overexpression

(2014) L. S. Eberlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

(2014) L. Xu et al.   Science Translational Medicine

Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging

(2014) Luca Tirinato et al.   STEM CELLS

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

(2014) Daniel Ackerman et al.   TRENDS IN CELL BIOLOGY

Involvement of eicosanoids in the pathogenesis of pancreatic cancer: The roles of cyclooxygenase-2 and 5-lipoxygenase

(2014) Lawrence M Knab   WORLD JOURNAL OF GASTROENTEROLOGY

Direct Visualization of De novo Lipogenesis in Single Living Cells

(2014) Junjie Li et al.   Scientific Reports

Induction of ER stress-mediated apoptosis by ceramide via disruption of ER Ca2+ homeostasis in human adenoid cystic carcinoma cells

(2014) Zhe Liu et al.   Cell and Bioscience

Characterization of MYC-Induced Tumorigenesis by in Situ Lipid Profiling

(2013) Richard H. Perry et al.   ANALYTICAL CHEMISTRY

Alkylphospholipids deregulate cholesterol metabolism and induce cell-cycle arrest and autophagy in U-87 MG glioblastoma cells

(2013) Pablo Ríos-Marco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

(2013) Alicia Llorente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity

(2013) K. J. Williams et al.   CANCER RESEARCH

High-resolution imaging mass spectrometry reveals detailed spatial distribution of phosphatidylinositols in human breast cancer

(2013) Masahiro Kawashima et al.   CANCER SCIENCE

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

(2013) N Sanchez-Macedo et al.   CELL DEATH AND DIFFERENTIATION

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

(2013) C. A. von Roemeling et al.   CLINICAL CANCER RESEARCH

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

(2013) Joao Tomé-Carneiro et al.   CURRENT PHARMACEUTICAL DESIGN

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

On the future of mass-spectrometry-based lipidomics

(2013) Ursula Loizides-Mangold   FEBS Journal

Membrane lipid saturation activates IRE1α without inducing clustering

(2013) Yuto Kitai et al.   GENES TO CELLS

Lipid raft regulates the initial spreading of melanoma A375 cells by modulating β1 integrin clustering

(2013) Ruifei Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells

(2013) Christian Steuwe et al.   Journal of Biophotonics

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

(2013) Gregory T. Kunkel et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics

(2013) Pedro M. R. Cruz et al.   Frontiers in Pharmacology

Non-glucose metabolism in cancer cells—is it all in the fat?

(2012) Swethajit Biswas et al.   CANCER AND METASTASIS REVIEWS

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

(2012) Pilar Caro et al.   CANCER CELL

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

(2012) M. Nagahashi et al.   CANCER RESEARCH

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Molecular Pathways: Tumor Cells Co-opt the Brain-Specific Metabolism Gene CPT1C to Promote Survival

(2012) P. T. Reilly et al.   CLINICAL CANCER RESEARCH

Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression

(2012) I. Mylonis et al.   JOURNAL OF CELL SCIENCE

Targeting tumor cell metabolism with statins

(2012) J W Clendening et al.   ONCOGENE

Exosomal Lipids Impact Notch Signaling and Induce Death of Human Pancreatic Tumoral SOJ-6 Cells

(2012) Sadia Beloribi et al.   PLoS One

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Targeting the ceramide system in cancer

(2011) Brian Henry et al.   CANCER LETTERS

Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression

(2011) M. Hilvo et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Nelfinavir Induces Liposarcoma Apoptosis through Inhibition of Regulated Intramembrane Proteolysis of SREBP-1 and ATF6

(2011) M. Guan et al.   CLINICAL CANCER RESEARCH

Lipid rafts: signaling and sorting platforms of cells and their roles in cancer

(2011) Simon Staubach et al.   Expert Review of Proteomics

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

(2011) K. Zaugg et al.   GENES & DEVELOPMENT

M2 Macrophages Induced by Prostaglandin E2 and IL-6 from Cervical Carcinoma Are Switched to Activated M1 Macrophages by CD4+ Th1 Cells

(2011) M. Heusinkveld et al.   JOURNAL OF IMMUNOLOGY

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma

(2011) S. Torres et al.   MOLECULAR CANCER THERAPEUTICS

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

(2011) D. Guo et al.   Cancer Discovery

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro

(2010) Viviana Anelli et al.   FASEB JOURNAL

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response

(2010) Hiroyuki Ariyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopy

(2010) Thuc T. Le et al.   JOURNAL OF LIPID RESEARCH

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

(2010) Caroline Subra et al.   JOURNAL OF LIPID RESEARCH

Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells

(2010) A J C Pommier et al.   ONCOGENE

Lipid droplets in inflammation and cancer

(2010) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid raft modulation inhibits NSCLC cell migration through delocalization of the focal adhesion complex

(2009) Jeong Hee Jeon et al.   LUNG CANCER

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions

(2009) M Reis-Sobreiro et al.   ONCOGENE

The role of COX-2 in intestinal inflammation and colorectal cancer

(2009) D Wang et al.   ONCOGENE

Antimetastatic Effects of Liposomal Gemcitabine and Empty Liposomes in an Orthotopic Mouse Model of Pancreatic Cancer

(2009) Ralph Graeser et al.   PANCREAS

Involvement of Raft Aggregates Enriched in Fas/CD95 Death-Inducing Signaling Complex in the Antileukemic Action of Edelfosine in Jurkat Cells

(2009) Consuelo Gajate et al.   PLoS One

Avicin D, a Plant Triterpenoid, Induces Cell Apoptosis by Recruitment of Fas and Downstream Signaling Molecules into Lipid Rafts

(2009) Zhi-Xiang Xu et al.   PLoS One

Cannabinoids for Cancer Treatment: Progress and Promise

(2008) S. Sarfaraz et al.   CANCER RESEARCH

Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma

(2008) J. Montero et al.   CANCER RESEARCH

Lipid Bodies Are Reservoirs of Cyclooxygenase-2 and Sites of Prostaglandin-E2 Synthesis in Colon Cancer Cells

(2008) M. T. Accioly et al.   CANCER RESEARCH

Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells

(2008) S. Fedida-Metula et al.   CARCINOGENESIS

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir

(2008) Emma Hernlund et al.   INTERNATIONAL JOURNAL OF CANCER

Induction of myeloid-derived suppressor cells by tumor exosomes

(2008) Xiaoyu Xiang et al.   INTERNATIONAL JOURNAL OF CANCER

Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer

(2008) Michael A. Kiebish et al.   JOURNAL OF LIPID RESEARCH