Viral vector-mediated gene therapy for opioid use disorders

Viral Vector-Mediated Gene Transfer of Glutamic Acid Decarboxylase for Chronic Pain Treatment: A Literature Review

(2020) Megumi Kanao-Kanda et al.   HUMAN GENE THERAPY

Immune Responses to Viral Gene Therapy Vectors

(2020) Jamie L. Shirley et al.   MOLECULAR THERAPY

Opioid use disorder

(2020) John Strang et al.   Nature Reviews Disease Primers

Mitragynine Attenuates Morphine Withdrawal Effects in Rats—A Comparison With Methadone and Buprenorphine

(2020) Rahimah Hassan et al.   Frontiers in Psychiatry

Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers

(2020) Xiangmin Xu et al.   NEURON

Opioid maintenance treatment: trajectories in and out of treatment

(2019) Bodil Monwell et al.   NORDIC JOURNAL OF PSYCHIATRY

The role of neurologists in tackling the opioid epidemic

(2019) Nora D. Volkow et al.   Nature Reviews Neurology

Transgenic increase in the β-endorphin concentration in cerebrospinal fluid alleviates morphine-primed relapse behavior through the μ opioid receptor in rats

(2019) Yan He et al.   JOURNAL OF MEDICAL VIROLOGY

Engineered endomorphin-2 gene: A novel therapy for improving morphine reinstatement in CPP model of rats by using deficient adenovirus as the vector

(2019) Xiaoqiang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury

(2019) Jarred M. Griffin et al.   GENE THERAPY

Epigenetic Mechanisms of Opioid Addiction

(2019) Caleb J. Browne et al.   BIOLOGICAL PSYCHIATRY

The mitochondrial calcium uniporter contributes to morphine tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn

(2019) K. Takahashi et al.   BRITISH JOURNAL OF ANAESTHESIA

Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders

(2019) Jamie A. Burns et al.   Frontiers in Psychiatry

Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats

(2019) Reza Arezoomandan et al.   Asian Journal of Psychiatry

Lentiviral Vectors and Adeno-Associated Virus Vectors: Useful Tools for Gene Transfer in Pain Research

(2018) Chen-Xi Zheng et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Association Between GSTP1 Ile105Val Genetic Polymorphism and Dependency to Heroin and Opium

(2018) Majede Rezaei et al.   BIOCHEMICAL GENETICS

Oxidative stress in opium users after using lead-adulterated opium: The role of genetic polymorphism

(2018) Saeedeh Shojaeepour et al.   FOOD AND CHEMICAL TOXICOLOGY

Potential role of the ecto-5′-nucleotidase in morphine-induced uridine release and neurobehavioral changes

(2018) Xiaohang Che et al.   NEUROPHARMACOLOGY

IL-4 mediated by HSV vector suppresses morphine withdrawal response and decreases TNFα, NR2B and pC/EBPβ in the periaqueductal gray in rats

(2017) H Yi et al.   GENE THERAPY

MnSOD mediated by HSV vectors in the periaqueductal gray suppresses morphine withdrawal in rats

(2017) T Iida et al.   GENE THERAPY

Nonintegrating Gene Therapy Vectors

(2017) Takis Athanasopoulos et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Arresting the Development of Addiction: The Role of β -Arrestin 2 in Drug Abuse

(2017) Kirsten A. Porter-Stransky et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

(2017) Gregory Corder et al.   NATURE MEDICINE

Viral vectors for therapy of neurologic diseases

(2017) Sourav R. Choudhury et al.   NEUROPHARMACOLOGY

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

(2017) Jerry R. Mendell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Going beyond prescription pain relievers to understand the opioid epidemic: the role of illicit fentanyl, new psychoactive substances, and street heroin

(2017) Joseph V. Pergolizzi et al.   POSTGRADUATE MEDICINE

miR-219-5p targets CaMKIIγ to attenuate morphine tolerance in rats

(2017) Jian Wang et al.   Oncotarget

MiR-218 targets MeCP2 and inhibits heroin seeking behavior

(2017) Biao Yan et al.   Scientific Reports

Toll-like Receptor-Dependent Negative Effects of Opioids: A Battle between Analgesia and Hyperalgesia

(2017) Masaud Shah et al.   Frontiers in Immunology

Opioid Receptors

(2016) Christoph Stein   Annual Review of Medicine

Reflections on: “A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function”

(2016) Eric J. Nestler   BRAIN RESEARCH

Update on pharmacotherapy for treatment of opioid use disorder

(2016) Daniel Ayanga et al.   EXPERT OPINION ON PHARMACOTHERAPY

Efficacy of Buprenorphine/Naloxone Rapidly Dissolving Sublingual Tablets (BNX-RDT) After Switching From BNX Sublingual Film

(2016) Erik W. Gunderson et al.   Journal of Addiction Medicine

Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia

(2016) Yang Cai et al.   Journal of Neuroinflammation

Brain Reward Circuits in Morphine Addiction

(2016) Juhwan Kim et al.   MOLECULES AND CELLS

Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

(2016) Lori N Eidson et al.   NEUROPSYCHOPHARMACOLOGY

Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

(2016) Michael J Lacagnina et al.   NEUROPSYCHOPHARMACOLOGY

AUTS2 in the nucleus accumbens is essential for heroin-induced behavioral sensitization

(2016) Yongsheng Zhu et al.   NEUROSCIENCE

Treatment of Opioid-Use Disorders

(2016) Marc A. Schuckit   NEW ENGLAND JOURNAL OF MEDICINE

miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats

(2016) Jian Wang et al.   Scientific Reports

The Brain on Drugs: From Reward to Addiction

(2015) Nora D. Volkow et al.   CELL

Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4

(2015) Ryan Bachtell et al.   CNS & Neurological Disorders-Drug Targets

Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders

(2015) Douglas Roberts-Wolfe et al.   CNS & Neurological Disorders-Drug Targets

Current Gene Therapy using Viral Vectors for Chronic Pain

(2015) Jean-Marc G Guedon et al.   Molecular Pain

Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

(2015) Ja Wook Koo et al.   NATURE NEUROSCIENCE

Understanding opioid reward

(2015) Howard L. Fields et al.   TRENDS IN NEUROSCIENCES

Herpes Simplex Viral Vectors: Late Bloomers with Big Potential

(2014) Joseph C. Glorioso   HUMAN GENE THERAPY

Enhancement of morphine analgesia and prevention of morphine tolerance by downregulation of β-arrestin 2 with antigene RNAs in mice

(2014) Huilian Bu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Synaptic Glutamate Spillover Due to Impaired Glutamate Uptake Mediates Heroin Relapse

(2014) H.-w. Shen et al.   JOURNAL OF NEUROSCIENCE

Nucleus Accumbens-Specific Interventions in RGS9-2 Activity Modulate Responses to Morphine

(2014) Sevasti Gaspari et al.   NEUROPSYCHOPHARMACOLOGY

Opioid receptor desensitization: mechanisms and its link to tolerance

(2014) Stéphane Allouche et al.   Frontiers in Pharmacology

Mapping the AAV Capsid Host Antibody Response toward the Development of Second Generation Gene Delivery Vectors

(2014) Yu-Shan Tseng et al.   Frontiers in Immunology

Helper Dependent Adenovirus Vectors: Progress and Future Prospects

(2013) Dan Cots et al.   CURRENT GENE THERAPY

Cholinergic control of morphine-induced locomotion in rostromedial tegmental nucleus versus ventral tegmental area sites

(2013) David I. Wasserman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference

(2013) A. M. Blouin et al.   LEARNING & MEMORY

Progress in gene therapy for neurological disorders

(2013) Michele Simonato et al.   Nature Reviews Neurology

Why is neuroimmunopharmacology crucial for the future of addiction research?

(2013) Mark R. Hutchinson et al.   NEUROPHARMACOLOGY

Amitriptyline attenuates astrocyte activation and morphine tolerance in rats: Role of the PSD-95/NR1/nNOS/PKCγ signaling pathway

(2012) Ya-Ni Huang et al.   BEHAVIOURAL BRAIN RESEARCH

Downregulation of cAMP response element-binding protein by lentiviral vector-mediated RNAi attenuates morphine withdrawal syndromes in rats

(2012) Qiang Wu et al.   BEHAVIOURAL BRAIN RESEARCH

Genetic analysis of AUTS2 as a susceptibility gene of heroin dependence

(2012) Yun-Hsiang Chen et al.   DRUG AND ALCOHOL DEPENDENCE

Morphine Epigenomically Regulates Behavior through Alterations in Histone H3 Lysine 9 Dimethylation in the Nucleus Accumbens

(2012) H. Sun et al.   JOURNAL OF NEUROSCIENCE

Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement

(2012) M. R. Hutchinson et al.   JOURNAL OF NEUROSCIENCE

Characterization of Basal and Morphine-Induced Uridine Release in the Striatum: An In Vivo Microdialysis Study in Mice

(2012) Wu Song et al.   NEUROCHEMICAL RESEARCH

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray

(2012) Handong Ouyang et al.   TheScientificWorldJOURNAL

Gene therapy for pain: Results of a phase I clinical trial

(2011) David J. Fink et al.   ANNALS OF NEUROLOGY

The epigenetic landscape of addiction

(2011) Ian Maze et al.   Annals of the New York Academy of Sciences

Suppression of acute morphine withdrawal syndrome by adenovirus-mediated β-endorphin in rats

(2011) Yan He et al.   BRAIN RESEARCH

Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal

(2011) F Martín et al.   BRITISH JOURNAL OF PHARMACOLOGY

Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human

(2011) Michael M Morgan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats

(2011) J Sun et al.   GENE THERAPY

On the Possible Role of ERK, p38 and CaMKII in the Regulation of CGRP Expression in Morphine-Tolerant Rats

(2011) Zhiyong Wang et al.   Molecular Pain

Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors

(2011) Elena E Bagley et al.   NATURE NEUROSCIENCE

Transcriptional and epigenetic mechanisms of addiction

(2011) Alfred J. Robison et al.   NATURE REVIEWS NEUROSCIENCE

IL-4 Deficiency Is Associated with Mechanical Hypersensitivity in Mice

(2011) Nurcan Üçeyler et al.   PLoS One

Addiction: Beyond dopamine reward circuitry

(2011) N. D. Volkow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical pharmacology of methadone for pain

(2010) O. M. S. FREDHEIM et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Etanercept Restores the Antinociceptive Effect of Morphine and Suppresses Spinal Neuroinflammation in Morphine-Tolerant Rats

(2010) Ching-Hui Shen et al.   ANESTHESIA AND ANALGESIA

Dopamine signals for reward value and risk: basic and recent data

(2010) Wolfram Schultz   Behavioral and Brain Functions

Mechanisms underlying morphine analgesic tolerance and dependence

(2010) Hiroshi Ueda   Frontiers in Bioscience-Landmark

Gene knockdown with lentiviral vector-mediated intrathecal RNA interference of protein kinase C gamma reverses chronic morphine tolerance in rats

(2010) Zongbin Song et al.   JOURNAL OF GENE MEDICINE

Localized disruption of Narp in medial prefrontal cortex blocks reinforcer devaluation performance

(2010) A. W. Johnson et al.   LEARNING & MEMORY

Recent Advances in Lentiviral Vector Development and Applications

(2010) Janka Mátrai et al.   MOLECULAR THERAPY

The Role of TNFα in the Periaqueductal Gray During Naloxone-Precipitated Morphine Withdrawal in Rats

(2010) Shuanglin Hao et al.   NEUROPSYCHOPHARMACOLOGY

Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons

(2010) J.-L. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

(2010) I. Maze et al.   SCIENCE

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Progress and prospects: immune responses to viral vectors

(2009) S Nayak et al.   GENE THERAPY

Improvement of Morphine-Mediated Analgesia by Inhibition of β-Arrestin 2 Expression in Mice Periaqueductal Gray Matter

(2009) Yuting Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia

(2009) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain

(2008) S HAO et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of transgene-mediated endomorphin-2 in inflammatory pain

(2008) Shuanglin Hao et al.   EUROPEAN JOURNAL OF PAIN

Manufacturing and characterizing AAV-based vectors for use in clinical studies

(2008) J F Wright   GENE THERAPY

M5 Muscarinic Receptor Knockout Mice Show Reduced Morphine-Induced Locomotion but Increased Locomotion after Cholinergic Antagonism in the Ventral Tegmental Area

(2008) S. Steidl et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Multiple Actions of Spinophilin Regulate Mu Opioid Receptor Function

(2008) Joanna J. Charlton et al.   NEURON

Narp Deletion Blocks Extinction of Morphine Place Preference Conditioning

(2008) Hans S Crombag et al.   NEUROPSYCHOPHARMACOLOGY