Progress and prospects: immune responses to viral vectors

Adenovirus Vector-Induced Innate Inflammatory Mediators, MAPK Signaling, As Well As Adaptive Immune Responses Are Dependent upon Both TLR2 and TLR9 In Vivo

(2014) D. M. Appledorn et al.   JOURNAL OF IMMUNOLOGY

AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

(2009) F. Mingozzi et al.   BLOOD

Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain

(2009) David M Markusic et al.   BMC BIOTECHNOLOGY

Hepatic Gene Transfer as a Means of Tolerance Induction to Transgene Products

(2009) Paul LoDuca et al.   CURRENT GENE THERAPY

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver

(2009) Ekaterina Breous et al.   HEPATOLOGY

Cytotoxic T Lymphocyte Responses to Transgene Product, Not Adeno-Associated Viral Capsid Protein, Limit Transgene Expression in Mice

(2009) William M. Siders et al.   HUMAN GENE THERAPY

Innate Immune Recognition of Viruses and Viral Vectors

(2009) Xiaopei Huang et al.   HUMAN GENE THERAPY

Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors

(2009) Gary C. Pien et al.   JOURNAL OF CLINICAL INVESTIGATION

The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice

(2009) Jiangao Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Adeno-Associated Virus Capsid Structure Drives CD4-Dependent CD8 + T Cell Response to Vector Encoded Proteins

(2009) Lauren E. Mays et al.   JOURNAL OF IMMUNOLOGY

Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

(2009) Roberto Calcedo et al.   JOURNAL OF INFECTIOUS DISEASES

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

(2009) S. NAYAK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Striatal Readministration of rAAV Vectors Reveals an Immune Response Against AAV2 Capsids That Can Be Circumvented

(2009) Carmen S Peden et al.   MOLECULAR THERAPY

New Insights on Adenovirus as Vaccine Vectors

(2009) Marcio O Lasaro et al.   MOLECULAR THERAPY

Transient Pretreatment With Glucocorticoid Ablates Innate Toxicity of Systemically Delivered Adenoviral Vectors Without Reducing Efficacy

(2009) Sergey S Seregin et al.   MOLECULAR THERAPY

Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans

(2009) Kara L O'Brien et al.   NATURE MEDICINE

Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells

(2009) Natalie A Hutnick et al.   NATURE MEDICINE

Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity

(2009) Ashley T. Martino et al.   PLoS One

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

(2009) M. L. Brantly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel Chimpanzee serotype-based adenoviral vector as delivery tool for cancer vaccines

(2009) Daniela Peruzzi et al.   VACCINE

Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy

(2008) V. M. Velazquez et al.   BLOOD

Immunity to adeno-associated virus vectors in animals and humans: a continued challenge

(2008) A K Zaiss et al.   GENE THERAPY

Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors

(2008) D M Appledorn et al.   GENE THERAPY

Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

(2008) William W. Hauswirth et al.   HUMAN GENE THERAPY

Diverse IgG subclass responses to adeno-associated virus infection and vector administration

(2008) Samuel L. Murphy et al.   JOURNAL OF MEDICAL VIROLOGY

Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors

(2008) A. K. Zaiss et al.   JOURNAL OF VIROLOGY

A Critical Role for Type I IFN–dependent NK Cell Activation in Innate Immune Elimination of Adenoviral Vectors In Vivo

(2008) Jiangao Zhu et al.   MOLECULAR THERAPY

The Host Response to Adenovirus, Helper-dependent Adenovirus, and Adeno-associated Virus in Mouse Liver

(2008) Anton P McCaffrey et al.   MOLECULAR THERAPY

Detection of Intact rAAV Particles up to 6 Years After Successful Gene Transfer in the Retina of Dogs and Primates

(2008) Knut Stieger et al.   MOLECULAR THERAPY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced Cytokine Secretion Owing to Multiple CpG Side Chains of DNA Duplex

(2008) Jusaku Minari et al.   OLIGONUCLEOTIDES

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

(2008) A. V. Cideciyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression

(2008) Li Zhong et al.   VIROLOGY