Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The study investigates the role of miR-26b in regulating morphine tolerance, showing that miR-26b alleviates morphine tolerance by inhibiting BDNF through the Wnt/beta-catenin pathway.
Article
Engineering, Biomedical
Patrick Reichenbach, Greta Maria Paola Giordano Attianese, Khaoula Ouchen, Elisabetta Cribioli, Melanie Triboulet, Sarah Ash, Margaux Saillard, Romain Vuillefroy de Silly, George Coukos, Melita Irving
Summary: This study reports the design and production of a lentiviral vector that incorporates two functionally independent promoters, allowing for the expression of a tumour-directed receptor and inducible gene in T cells. The vector enables the delivery of various genes to human T cells, improving the safety and efficacy of T-cell therapies.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Alok K. Paul, Nuri Gueven, Nikolas Dietis
Summary: The clinical use of morphine is limited by its side effects and the need for increasing doses to achieve adequate analgesia due to tolerance. High-dose morphine exposure leads to excitatory locomotor effects in animals, which later converts into an inhibitory effect on behavior.
Article
Neurosciences
Meiling Deng, Zengli Zhang, Manyu Xing, Xia Liang, Zhengyiqi Li, Jing Wu, Shasha Jiang, Yingqi Weng, Qulian Guo, Wangyuan Zou
Summary: Long noncoding RNA MRAK15 9688 is significantly upregulated in the spinal cord of morphine-tolerant rats. It promotes the formation of morphine tolerance by enhancing the expression and function of REST in the nucleus, leading to the inhibition of MOR expression. Downregulation of MRAK15 9688 may represent a novel RNA-based therapy for morphine tolerance.
Article
Biochemistry & Molecular Biology
Yaswanth Kuthati, Prabhakar Busa, Srikrishna Tummala, Vaikar Navakanth Rao, Venkata Naga Goutham Davuluri, Yen-Peng Ho, Chih-Shung Wong
Summary: Research has shown that delivering morphine through an antioxidant nanocarrier may be an effective strategy to alleviate morphine antinociceptive tolerance, potentially playing a positive role in neuropathic pain management.
Article
Microbiology
Jana Hagen, Peter Sarkies, Murray E. Selkirk
Summary: The use of a pseudotyped viral vector has successfully enabled genetic manipulation of parasitic nematodes, including gene silencing and expression of exogenous genes. This method holds promise for advancing research on the complex biology of nematode parasites and identifying new targets for infection control.
Article
Biotechnology & Applied Microbiology
Benjamin Vesin, Jodie Lopez, Amandine Noirat, Pierre Authie, Ingrid Fert, Fabien Le Chevalier, Fanny Moncoq, Kirill Nemirov, Catherine Blanc, Cyril Planchais, Hugo Mouquet, Francoise Guinet, David Hardy, Francina Langa Vives, Christiane Gerke, Francois Anna, Maryline Bourgine, Laleh Majlessi, Pierre Charneau
Summary: For COVID-19, intranasal boosting with LV::SBeta-2P vaccine can effectively enhance cross-sero-neutralizing activity and systemic T cell immunity. In addition, the vaccine efficiently induces mucosal antibodies, lung-resident B cells, and effector memory and resident T cells, providing protection against both SARS-CoV-2 Delta variant and Omicron infection in the lungs.
Article
Biochemistry & Molecular Biology
Xiaoqian Jia, Anqi Zhang, Zheng Li, Xiaoling Peng, Xuebi Tian, Feng Gao
Summary: This study found that spinal PDGFR beta in microglia promotes autophagy in GABA interneurons through activating the p38 MAPK pathway, which plays a significant role in the development of morphine tolerance.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Virology
Christopher Perry, Andrea C. M. E. Rayat
Summary: This comprehensive review discusses the importance of individual bioprocess operations in lentiviral vector (LV) production, emphasizing the role of envelope proteins and bioprocessing on LVs. It explores considerations for optimization and scalability during production, as well as key steps such as purification and quantification of LVs.
Article
Behavioral Sciences
Qian-Mei Zhu, Lin-Xin Wu, Bo Zhang, Yan-Peng Dong, Li Sun
Summary: This study demonstrated that donepezil can attenuate morphine-induced tolerance by downregulating the expressions of NMDAR, PKC, and CaMKII pathways. Co-administration of donepezil with morphine prolonged the occurrence of analgesic tolerance in rats. Specifically, morphine upregulated NR1, PKC gamma, and CaMKII alpha in certain brain regions, while downregulating these proteins with donepezil treatment.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Manyu Xing, Meiling Deng, Yufei Shi, Jiajia Dai, Tong Ding, Zongbin Song, Wangyuan Zou
Summary: In this study, the patterns of m(6)A-methylation of circRNAs in the spinal cord of morphine-tolerant rats were explored. The results indicated that m(6)A modification of circRNAs may be involved in the pathogenesis of morphine tolerance, providing new insights into the epigenetic etiology and pathology of this condition.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Safiye Ozdemir-cezik, Asiye Nurten, Berna Midilli, Basak Guertekin, Nurhan Enginar
Summary: The study found that oxytocin can influence morphine tolerance and dependence, while enhancing signaling of alpha-2 adrenoceptors.
NEUROSCIENCE LETTERS
(2022)
Article
Virology
Maira Zorzan, Claudia Del Vecchio, Stefania Vogiatzis, Elisa Saccon, Cristina Parolin, Giorgio Palu, Arianna Calistri, Carla Mucignat-Caretta
Summary: In this study, a third-generation lentiviral system was developed to deliver shRNA targeting the regulatory subunit R2Alpha of protein kinase A, resulting in efficient and stable downregulation of R2Alpha in glioblastoma cells. The silencing of R2Alpha was found to potentially reduce the viability of tumor cells, highlighting the promising role of protein kinase A as a target for novel anti-glioma therapies.
Article
Biochemistry & Molecular Biology
Yuanxue Yang, Ailing Duan, Cong Zhang, Yun Zhang, Aiyu Wang, Chao Xue, Hongyan Wang, Ming Zhao, Jianhua Zhang
Summary: Aphis craccivora, a pest that threatens legumes, has developed resistance to various insecticides. This study investigates the role of ABC transporters in the tolerance of imidacloprid in A. craccivora. It identifies fifty-eight ABC transporters and finds that inhibiting certain ABC transporters increases the toxicity of imidacloprid. Moreover, the study shows that knockdown of specific ABC transporters increases the mortality of A. craccivora to imidacloprid.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Neurosciences
Ahmet Sevki Taskiran, Onur Avci
Summary: The study found that captopril has anti-nociceptive properties, increases the analgesic effect of morphine, and reduces the development of morphine tolerance. These effects may be achieved by suppressing inflammation and ER-stress pathways.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Zhong Zhang, Yuan Chen, E. Wang, Lei Wu, Ruike Wang, Zongbin Song, Yingqi Weng, Zhihua Sun, Qulian Guo, Yunping Li
NEUROCHEMICAL RESEARCH
(2018)
Article
Neurosciences
Xinran Hou, Yingqi Weng, Tongxuan Wang, Bihan Ouyang, Yalin Li, Zongbin Song, Yundan Pan, Zhong Zhang, Wangyuan Zou, Changsheng Huang, Qulian Guo
Article
Anesthesiology
Zongbin Song, Wenrui Xie, Judith A. Strong, Temugin Berta, Yvonne M. Ulrich-Lai, Qulian Guo, Jun-Ming Zhang
Article
Multidisciplinary Sciences
Zongbin Song, Wenrui Xie, Sisi Chen, Judith A. Strong, Mason S. Print, Joy I. Wang, Aleeya F. Shareef, Yvonne M. Ulrich-Lai, Jun-Ming Zhang
SCIENTIFIC REPORTS
(2017)
Article
Anesthesiology
Jiajia Dai, Zhuofeng Ding, Jie Zhang, Wei Xu, Qulian Guo, Wangyuan Zou, Yunchuan Xiong, Yingqi Weng, Yong Yang, Sisi Chen, Jun-Ming Zhang, Zongbin Song
ANESTHESIA AND ANALGESIA
(2019)
Article
Anesthesiology
Zhen Du, Xi-Ying Zhang, Shuang-Quan Qu, Zong-Bing Song, Si-Wei Wei, Zhen Xiang, Qu-Lian Guo
PEDIATRIC ANESTHESIA
(2019)
Article
Neurosciences
Bihan Ouyang, Dan Chen, Xinran Hou, Tongxuan Wang, Jian Wang, Wangyuan Zou, Zongbin Song, Changsheng Huang, Qulian Guo, Yingqi Weng
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Neurosciences
Jiangju Huang, Xia Liang, Jian Wang, Yan Kong, Zengli Zhang, Zhuofeng Ding, Zongbin Song, Qulian Guo, Wangyuan Zou
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Neurosciences
Hou Xinran, Weng Yingqi, Guo Qulian, Ding Zhuofeng, Wang Jian, Dai Jiajia, Wei Anqi, Song Zongbin
Article
Toxicology
Zhong Zhang, Jian Wang, Zongbin Song, Yunjiao Wang, Zhigang Cheng, Qulian Guo, E. Wang, Yanping Jian, Lei Wu
Summary: This study revealed that miR-199a-5p is involved in 10% lidocaine-induced spinal cord toxicity by regulating MYRF expression, suggesting that downregulating miR-199a-5p may be a potential strategy to alleviate neurotoxicity induced by lidocaine.
TOXICOLOGY LETTERS
(2021)
Article
Anesthesiology
E. Wang, Lu Wang, Chunyan Ye, Ning Luo, Yanrong Zhang, Yugui Zhong, Maoen Zhu, Yu Zou, Qian Li, Longyan Li, Zongbin Song, Hui Luo, Feng Dai, Hong Liu, Adrian W. Gelb, Qulian Guo, Lingzhong Meng
Summary: A randomized trial involving 1560 patients undergoing laparoscopic surgery found that SedLine EEG-guided anesthetic care did not alter anesthetic delivery or decrease the incidence of postoperative delirium compared to usual care in relatively young Chinese patients.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2022)
Article
Medicine, General & Internal
Xinran Hou, Zongbin Song, Fan Zhang, Zhuoyi Liu, Wenyong Long, Zheng Long, Maigeng Zhou, E. Wang, Peng Yin, Maoen Zhu
Summary: The trends in disease burden and epidemiological features of CNS cancer in China from 1990 to 2019 were evaluated. The burden of CNS cancer has been increasing in China, with no significant differences between men and women but more pronounced in children and the elderly. The burden varies significantly at the subnational level and is associated with socioeconomic development.
Article
Neurosciences
Wei Xu, Zhuofeng Ding, Zongbin Song, Jian Wang, Jie Zhang, Wangyuan Zou
Summary: Bone cancer pain (BCP) is a distressing symptom in cancer patients, and long-term morphine use leads to tolerance. The study found that decreased GDNF expression in BCP rats was associated with morphine tolerance, and overexpression of GDNF attenuated tolerance.
Article
Biology
Yanping Jian, Zongbin Song, Zhuofeng Ding, Jian Wang, Ruike Wang, Xinran Hou
Summary: This study suggests that spinal miR-155-5p/Sgk3/microglial activation may play a significant role in the pathogenesis of bone cancer pain (BCP).
Article
Public, Environmental & Occupational Health
Xinran Hou, Wei Xu, Chengliang Zhang, Zongbin Song, Maoen Zhu, Qulian Guo, Jian Wang
Summary: This study finds that decreased serum chloride concentrations in American adults are independently associated with increased all-cause mortality, cardiovascular disease mortality, cancer mortality, and respiratory disease mortality. Serum chloride may serve as a promising cost-effective health indicator in the general adult population.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)