Toll-like Receptor-Dependent Negative Effects of Opioids: A Battle between Analgesia and Hyperalgesia

Opioid-induced hyperalgesia: Cellular and molecular mechanisms

(2016) Laurie-Anne Roeckel et al.   NEUROSCIENCE

Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

(2016) Agnieszka M. Jurga et al.   NEURAL PLASTICITY

A structural insight into the negative effects of opioids in analgesia by modulating the TLR4 signaling: An in silico approach

(2016) Masaud Shah et al.   Scientific Reports

Regulation of microglia activation and deactivation by nuclear receptors

(2012) Kaoru Saijo et al.   GLIA

Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement

(2012) M. R. Hutchinson et al.   JOURNAL OF NEUROSCIENCE

Alleviating Suffering 101 — Pain Relief in the United States

(2012) Philip A. Pizzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain

(2011) Peter M. Grace et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like receptors in chronic pain

(2011) Lauren Nicotra et al.   EXPERIMENTAL NEUROLOGY

Toll-Like Receptor 2 Contributes to Chemokine Gene Expression and Macrophage Infiltration in the Dorsal Root Ganglia after Peripheral Nerve Injury

(2011) Donghoon Kim et al.   Molecular Pain

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

(2011) M. R. Hutchinson et al.   PHARMACOLOGICAL REVIEWS

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response

(2010) Xiang Qun Shi et al.   GLIA

TLR4 Activation Induces Nontolerant Inflammatory Response in Endothelial Cells

(2010) Wenmeng Wang et al.   INFLAMMATION

Central modulation of pain

(2010) Michael H. Ossipov et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptor 4 in CNS pathologies

(2010) Madison M. Buchanan et al.   JOURNAL OF NEUROCHEMISTRY

Neuregulin-ErbB Signaling Promotes Microglial Proliferation and Chemotaxis Contributing to Microgliosis and Pain after Peripheral Nerve Injury

(2010) M. Calvo et al.   JOURNAL OF NEUROSCIENCE

Glia: The many ways to modulate synaptic plasticity

(2010) S. Ben Achour et al.   NEUROCHEMISTRY INTERNATIONAL

Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice

(2010) Yi Zhang et al.   NEUROSCIENCE LETTERS

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury

(2009) Seija Lehnardt   GLIA

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Large A-Fiber Activity is Required for Microglial Proliferation and P38 MAPK Activation in the Spinal Cord: Different Effects of Resiniferatoxin and Bupivacaine on Spinal Microglial Changes after Spared Nerve Injury

(2009) Marc R Suter et al.   Molecular Pain

Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats

(2009) M.R. Hutchinson et al.   NEUROSCIENCE

Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1β

(2009) S.S. Lewis et al.   NEUROSCIENCE

Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice

(2009) Amanda R. Waxman et al.   NEUROSCIENCE LETTERS

The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia

(2009) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

THIS ARTICLE HAS BEEN RETRACTED: Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury

(2008) Koichi Obata et al.   JOURNAL OF NEUROCHEMISTRY

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE