Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Opioid-induced hyperalgesia: Cellular and molecular mechanisms

(2016) Laurie-Anne Roeckel et al.   NEUROSCIENCE

Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies

(2016) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gliogenic LTP spreads widely in nociceptive pathways

(2016) M. T. Kronschlager et al.   SCIENCE

Treatment With Prolonged-Release Oxycodone/Naloxone Improves Pain Relief and Opioid-Induced Constipation Compared With Prolonged-Release Oxycodone in Patients With Chronic Severe Pain and Laxative-Refractory Constipation

(2015) Jan Poelaert et al.   CLINICAL THERAPEUTICS

Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics

(2015) T. Trang et al.   JOURNAL OF NEUROSCIENCE

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Analysis of opioid-mediated analgesia in Phase III studies of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain

(2015) Lynn Webster et al.   Journal of Pain Research

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Olfactory exposure to males, including men, causes stress and related analgesia in rodents

(2014) Robert E Sorge et al.   NATURE METHODS

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

(2014) Rita Bardoni et al.   NEURON

Peripheral opioid receptor blockade increases postoperative morphine demands—A randomized, double-blind, placebo-controlled trial

(2014) Christina Jagla et al.   PAIN

Toll-Like Receptor 4 Mutant and Null Mice Retain Morphine-Induced Tolerance, Hyperalgesia, and Physical Dependence

(2014) Theresa Alexandra Mattioli et al.   PLoS One

Methylnaltrexone: its pharmacological effects alone and effects on morphine in healthy volunteers

(2014) James P. Zacny et al.   PSYCHOPHARMACOLOGY

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

(2013) Simone Picelli et al.   NATURE METHODS

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

Opioids and their receptors: Are we there yet?

(2013) Gavril W. Pasternak   NEUROPHARMACOLOGY

Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats

(2013) Shao-Qiu He et al.   PAIN

Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice

(2013) Raphaël Weibel et al.   PLoS One

Constitutive  -Opioid Receptor Activity Leads to Long-Term Endogenous Analgesia and Dependence

(2013) G. Corder et al.   SCIENCE

Microglial activation involved in morphine tolerance is not mediated by toll-like receptor 4

(2012) Hiroshi Fukagawa et al.   Journal of Anesthesia

Chronic Opioid Potentiates Presynaptic but Impairs PostsynapticN-Methyl-d-aspartic Acid Receptor Activity in Spinal Cords

(2012) Yi-Lin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of PDGFR-β activation eliminates morphine analgesic tolerance

(2012) Yan Wang et al.   NATURE MEDICINE

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Absence of μ opioid receptor mRNA expression in astrocytes and microglia of rat spinal cord

(2012) Sheng-Chin Kao et al.   NEUROREPORT

Safety and Efficacy of Methylnaltrexone in Shortening the Duration of Postoperative Ileus Following Segmental Colectomy: Results of Two Randomized, Placebo-Controlled Phase 3 Trials

(2011) Chang Sik Yu et al.   DISEASES OF THE COLON & RECTUM

Restriction of Transient Receptor Potential Vanilloid-1 to the Peptidergic Subset of Primary Afferent Neurons Follows Its Developmental Downregulation in Nonpeptidergic Neurons

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

Distinct Mechanisms Underlying Pronociceptive Effects of Opioids

(2011) C. Heinl et al.   JOURNAL OF NEUROSCIENCE

Multiple Targets of  -Opioid Receptor-Mediated Presynaptic Inhibition at Primary Afferent A - and C-Fibers

(2011) B. Heinke et al.   JOURNAL OF NEUROSCIENCE

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy

(2011) Ruth Ruscheweyh et al.   Molecular Pain

Development of a Method for the Purification and Culture of Rodent Astrocytes

(2011) Lynette C. Foo et al.   NEURON

Tonic inhibition of chronic pain by neuropeptide Y

(2011) B. Solway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Shared Mechanisms for Opioid Tolerance and a Transition to Chronic Pain

(2010) E. K. Joseph et al.   JOURNAL OF NEUROSCIENCE

Opioid-Induced Long-Term Potentiation in the Spinal Cord Is a Presynaptic Event

(2010) H.-Y. Zhou et al.   JOURNAL OF NEUROSCIENCE

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice

(2010) Yi Zhang et al.   NEUROSCIENCE LETTERS

Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and μ opioid receptor protein expression while enhancing perivascular microglial ED2

(2010) Ryan J. Horvath et al.   PAIN

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Peripheral mechanisms of pain and analgesia

(2009) Christoph Stein et al.   BRAIN RESEARCH REVIEWS

Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

(2009) Grégory Scherrer et al.   CELL

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Induction of Synaptic Long-Term Potentiation After Opioid Withdrawal

(2009) R. Drdla et al.   SCIENCE

Critical role of nociceptor plasticity in chronic pain

(2009) David B. Reichling et al.   TRENDS IN NEUROSCIENCES

The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia

(2009) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

(2008) M J Christie   BRITISH JOURNAL OF PHARMACOLOGY

Opioid-induced Hyperalgesia in Humans

(2008) Larry F. Chu et al.   CLINICAL JOURNAL OF PAIN

Cell‐specific actions of HIV‐Tat and morphine on opioid receptor expression in glia

(2008) Jadwiga Turchan‐Cholewo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness

(2008) Jay Thomas et al.   NEW ENGLAND JOURNAL OF MEDICINE