Journal
ASIAN JOURNAL OF PSYCHIATRY
Volume 46, Issue -, Pages 70-73Publisher
ELSEVIER
DOI: 10.1016/j.ajp.2019.10.007
Keywords
Minocycline; Glutamate transporter 1; Nucleus accumbens; Morphine dependency; Immunohistochemistry; Rat
Categories
Funding
- Vice-Chancellor for Research & Technology of Shahid Beheshti University of Medical Sciences, Tehran, Iran [92-261-A]
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Glial glutamate transporters (GLT-1) is responsible for glutamate homeostasis. GLT-1 expression and glutamate uptake can be affected by addictive drugs and can be used as a target in addiction pharmacotherapy. It has been shown that minocycline, an antibiotic with anti-inflammatory, and neuroprotective properties, can upregulate the expression of GLT-1. In the present study, in morphine-dependent rats, the effect of minocycline on expression of GLT-1 in nucleus accumbens was investigated by immunohistochemistry. The expression of GLT-1 significantly increased in minocycline treated animals. In line with other studies, our findings showed that restoring GLT-1 expression with minocycline might be considered as a potential target for correcting pre-clinical and clinical manifestations of drug addiction.
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