Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human

How to design an opioid drug that causes reduced tolerance and dependence

(2010) Amy Chang Berger et al.   ANNALS OF NEUROLOGY

Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment

(2010) Vadim Yuferov et al.   Annals of the New York Academy of Sciences

Prescription Drug Abuse: Insight Into the Epidemic

(2010) S H Hernandez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The pharmacological treatment of opioid addiction—a clinical perspective

(2010) Philipp Lobmaier et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Involvement of Spinal Microglial P2X7 Receptor in Generation of Tolerance to Morphine Analgesia in Rats

(2010) D. Zhou et al.   JOURNAL OF NEUROSCIENCE

The Influence of Non-Nociceptive Factors on Hot-Plate Latency in Rats

(2010) Amanda Gunn et al.   JOURNAL OF PAIN

 -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

(2010) J. McPherson et al.   MOLECULAR PHARMACOLOGY

A Novel 12-Week Study, with Three Randomized, Double-Blind Placebo-Controlled Periods to Evaluate Fentanyl Buccal Tablets for the Relief of Breakthrough Pain in Opioid-Tolerant Patients with Noncancer-Related Chronic Pain

(2010) John T. Farrar et al.   PAIN MEDICINE

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling

(2010) E. J. Melief et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

The Effect of Protein Kinase C and G Protein-Coupled Receptor Kinase Inhibition on Tolerance Induced by  -Opioid Agonists of Different Efficacy

(2009) L. C. Hull et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Extracellular Signal-Regulated Kinase 1/2 Activation Counteracts Morphine Tolerance in the Periaqueductal Gray of the Rat

(2009) T. A. Macey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Do Opioids Induce Hyperalgesia in Humans? An Evidence-Based Structured Review

(2009) David A. Fishbain et al.   PAIN MEDICINE

Dosing protocol and analgesic efficacy determine opioid tolerance in the mouse

(2009) Priyanka A. Madia et al.   PSYCHOPHARMACOLOGY

Self-administration of cocaine, cannabis and heroin in the human laboratory: benefits and pitfalls

(2008) Margaret Haney   ADDICTION BIOLOGY

Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

(2008) M J Christie   BRITISH JOURNAL OF PHARMACOLOGY

Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptors

(2008) P G Strange   BRITISH JOURNAL OF PHARMACOLOGY

The role of human drug self-administration procedures in the development of medications

(2008) S.D. Comer et al.   DRUG AND ALCOHOL DEPENDENCE

Hydromorphone efficacy and treatment protocol impact on tolerance and μ-opioid receptor regulation

(2008) Priyank Kumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sex differences in analgesic, reinforcing, discriminative, and motoric effects of opioids.

(2008) Rebecca M. Craft   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

A Novel G  -Subunit Inhibitor Selectively Modulates  -Opioid-Dependent Antinociception and Attenuates Acute Morphine-Induced Antinociceptive Tolerance and Dependence

(2008) J. L. Mathews et al.   JOURNAL OF NEUROSCIENCE

Differential Activation and Trafficking of  -Opioid Receptors in Brain Slices

(2008) S. Arttamangkul et al.   MOLECULAR PHARMACOLOGY

The analgesic efficacy of fentanyl: Relationship to tolerance and μ-opioid receptor regulation

(2008) S SIROHI et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Context-induced relapse to drug seeking: a review

(2008) H. S Crombag et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Controversies in translational research: drug self-administration

(2008) Margaret Haney et al.   PSYCHOPHARMACOLOGY

Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone)

(2008) Joseph Pergolizzi et al.   Pain Practice

Differential activation of G-proteins by μ-opioid receptor agonists

(2006) Zuzana Saidak et al.   BRITISH JOURNAL OF PHARMACOLOGY