Current Gene Therapy using Viral Vectors for Chronic Pain

A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease

(2014) Michael S. Rafii et al.   Alzheimers & Dementia

Interleukin 10 Mediated by Herpes Simplex Virus Vectors Suppresses Neuropathic Pain Induced by Human Immunodeficiency Virus gp120 in Rats

(2014) Wenwen Zheng et al.   ANESTHESIA AND ANALGESIA

Mechanical Allodynia Induced by Nucleoside Reverse Transcriptase Inhibitor Is Suppressed by p55TNFSR Mediated by Herpes Simplex Virus Vector Through the SDF1 alpha/CXCR4 System in Rats

(2014) Wan Huang et al.   ANESTHESIA AND ANALGESIA

Preclinical Toxicity Screening of Intrathecal Oxytocin in Rats and Dogs

(2014) Tony L. Yaksh et al.   ANESTHESIOLOGY

Noncoding RNAs

(2014) Brianna Marie Lutz et al.   ANESTHESIOLOGY

Decrease in neuroimmune activation by HSV-mediated gene transfer of TNFα soluble receptor alleviates pain in rats with diabetic neuropathy

(2014) Kathryn L. Maier Ortmann et al.   BRAIN BEHAVIOR AND IMMUNITY

Relief of pain induced by varicella-zoster virus in a rat model of post-herpetic neuralgia using a herpes simplex virus vector expressing enkephalin

(2014) J-M G Guedon et al.   GENE THERAPY

High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs

(2014) J Pleticha et al.   GENE THERAPY

HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity

(2014) W Huang et al.   GENE THERAPY

IL-10 Mediated by Herpes Simplex Virus Vector Reduces Neuropathic Pain Induced by HIV gp120 Combined with ddC in Rats

(2014) Wenwen Zheng et al.   Molecular Pain

Impaired Neuropathic Pain and Preserved Acute Pain in Rats Overexpressing Voltage-Gated Potassium Channel Subunit Kv1.2 in Primary Afferent Neurons

(2014) Longchang Fan et al.   Molecular Pain

Distinct role of tumor necrosis factor receptor subtypes 1 and 2 in the red nucleus in the development of neuropathic pain

(2014) Xiao-Yan Zeng et al.   NEUROSCIENCE LETTERS

Gene Therapy for Neuropathic Pain by Silencing of TNF-α Expression with Lentiviral Vectors Targeting the Dorsal Root Ganglion in Mice

(2014) Nobuhiro Ogawa et al.   PLoS One

Supraspinal gene transfer by intrathecal adeno-associated virus serotype 5

(2014) Daniel J. Schuster et al.   Frontiers in Neuroanatomy

Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse

(2014) Daniel J. Schuster et al.   Frontiers in Neuroanatomy

Practical considerations in the pharmacological treatment of postherpetic neuralgia for the primary care provider

(2014) Jamie Massengill et al.   Journal of Pain Research

Morphine mediates a proinflammatory phenotype via μ-opioid receptor–PKCɛ–Akt–ERK1/2 signaling pathway in activated microglial cells

(2013) Stefania Merighi et al.   BIOCHEMICAL PHARMACOLOGY

NF-κB, ERK, p38 MAPK and JNK contribute to the initiation and/or maintenance of mechanical allodynia induced by tumor necrosis factor-alpha in the red nucleus

(2013) Qian Zhang et al.   BRAIN RESEARCH BULLETIN

The Molecular and Pharmacological Mechanisms of HIV-Related Neuropathic Pain

(2013) Shuanglin Hao   Current Neuropharmacology

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

(2013) S J Gray et al.   GENE THERAPY

Intracerebroventricular Injection of Adeno-Associated Virus 6 and 9 Vectors for Cell Type–Specific Transgene Expression in the Spinal Cord

(2013) Elisabeth Dirren et al.   HUMAN GENE THERAPY

Herpes Zoster Eye Complications: Rates and Trends

(2013) Barbara P. Yawn et al.   MAYO CLINIC PROCEEDINGS

AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction

(2013) Lluis Samaranch et al.   MOLECULAR THERAPY

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

(2013) Xiuli Zhao et al.   NATURE NEUROSCIENCE

Why is neuroimmunopharmacology crucial for the future of addiction research?

(2013) Mark R. Hutchinson et al.   NEUROPHARMACOLOGY

Epidermal adrenergic signaling contributes to inflammation and pain sensitization in a rat model of complex regional pain syndrome

(2013) Wenwu Li et al.   PAIN

Neuropathic pain in the general population: A systematic review of epidemiological studies

(2013) O. van Hecke et al.   PAIN

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

Epidemiology of Neuropathic Pain and Its Impact on Quality of Life

(2012) Blair H. Smith et al.   Current Pain and Headache Reports

Herpes Zoster in Patients Treated with Biologicals

(2012) V. Failla et al.   DERMATOLOGY

The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy

(2012) J. Blackbeard et al.   EUROPEAN JOURNAL OF PAIN

Effect of herpes simplex virus vector-mediated interleukin-4 gene therapy on bladder overactivity and nociception

(2012) T Oguchi et al.   GENE THERAPY

Correction of Pathological Accumulation of Glycosaminoglycans in Central Nervous System and Peripheral Tissues of MPSIIIA Mice Through Systemic AAV9 Gene Transfer

(2012) Albert Ruzo et al.   HUMAN GENE THERAPY

Herpes Simplex Virus Vector Mediated Gene Therapy of Tumor Necrosis Factor-α Blockade for Bladder Overactivity and Nociception in Rats

(2012) Yasuhito Funahashi et al.   JOURNAL OF UROLOGY

Virus-mediated shRNA Knockdown of Nav1.3 in Rat Dorsal Root Ganglion Attenuates Nerve Injury-induced Neuropathic Pain

(2012) Omar A Samad et al.   MOLECULAR THERAPY

Gene therapy for the treatment of chronic peripheral nervous system pain

(2012) William F. Goins et al.   NEUROBIOLOGY OF DISEASE

Adeno-associated virus (AAV) gene therapy for neurological disease

(2012) Marc S. Weinberg et al.   NEUROPHARMACOLOGY

Targeted drug delivery to the peripheral nervous system using gene therapy

(2012) Darren Wolfe et al.   NEUROSCIENCE LETTERS

Gene therapy for pain: Results of a phase I clinical trial

(2011) David J. Fink et al.   ANNALS OF NEUROLOGY

Viral infections associated with the clinical use of monoclonal antibodies

(2011) G. Gentile et al.   CLINICAL MICROBIOLOGY AND INFECTION

Vector-mediated release of GABA attenuates pain-related behaviors and reduces NaV1.7 in DRG neurons

(2011) Munmun Chattopadhyay et al.   EUROPEAN JOURNAL OF PAIN

Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats

(2011) J Sun et al.   GENE THERAPY

Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates

(2011) Lluis Samaranch et al.   HUMAN GENE THERAPY

Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal models

(2011) Paul R. Kinchington et al.   JOURNAL OF NEUROVIROLOGY

Post Herpetic Neuralgia

(2011) Annie Philip et al.   JOURNAL OF PALLIATIVE MEDICINE

Risk of Herpes zoster in patients with psoriasis treated with biologic drugs

(2011) J. Dreiher et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Microglia: A Promising Target for Treating Neuropathic and Postoperative Pain, and Morphine Tolerance

(2011) Yeong-Ray Wen et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

(2011) Peter A LeWitt et al.   LANCET NEUROLOGY

On the Possible Role of ERK, p38 and CaMKII in the Regulation of CGRP Expression in Morphine-Tolerant Rats

(2011) Zhiyong Wang et al.   Molecular Pain

Are Voltage-Gated Sodium Channels on the Dorsal Root Ganglion Involved in the Development of Neuropathic Pain?

(2011) Wei Wang et al.   Molecular Pain

AAV Vectors for Cardiac Gene Transfer: Experimental Tools and Clinical Opportunities

(2011) Christina A Pacak et al.   MOLECULAR THERAPY

Gene therapy for Huntington's disease

(2011) Shilpa Ramaswamy et al.   NEUROBIOLOGY OF DISEASE

Viral vectors for gene delivery to the central nervous system

(2011) Thomas B. Lentz et al.   NEUROBIOLOGY OF DISEASE

Spinal Astrocytic Activation Is Involved in a Virally-Induced Rat Model of Neuropathic Pain

(2011) Gui-He Zhang et al.   PLoS One

Etanercept Restores the Antinociceptive Effect of Morphine and Suppresses Spinal Neuroinflammation in Morphine-Tolerant Rats

(2010) Ching-Hui Shen et al.   ANESTHESIA AND ANALGESIA

Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1

(2010) Yong-Jing Gao et al.   GLIA

The impact of varicella zoster virus: Chronic pain

(2010) Wim Opstelten et al.   JOURNAL OF CLINICAL VIROLOGY

Prevention strategies for herpes zoster and post-herpetic neuralgia

(2010) Myron J. Levin et al.   JOURNAL OF CLINICAL VIROLOGY

Management of herpes zoster and post-herpetic neuralgia now and in the future

(2010) Richard J. Whitley et al.   JOURNAL OF CLINICAL VIROLOGY

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

(2010) Paul J. Austin et al.   JOURNAL OF NEUROIMMUNOLOGY

TNF-α and neuropathic pain - a review

(2010) Lawrence Leung et al.   Journal of Neuroinflammation

Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids

(2010) C. Muscoli et al.   JOURNAL OF NEUROSCIENCE

The Prevalence of Chronic Pain in United States Adults: Results of an Internet-Based Survey

(2010) Catherine B. Johannes et al.   JOURNAL OF PAIN

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

Differential Adeno-Associated Virus Mediated Gene Transfer to Sensory Neurons following Intrathecal Delivery by Direct Lumbar Puncture

(2010) Lucy Vulchanova et al.   Molecular Pain

The Role of TNFα in the Periaqueductal Gray During Naloxone-Precipitated Morphine Withdrawal in Rats

(2010) Shuanglin Hao et al.   NEUROPSYCHOPHARMACOLOGY

A novel cell–cell signaling by microglial transmembrane TNFα with implications for neuropathic pain

(2010) Zhigang Zhou et al.   PAIN

Review article: chronic viral infection in the anti-tumour necrosis factor therapy era in inflammatory bowel disease

(2009) M. J. SHALE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats

(2009) Yueh-Hua Tai et al.   ANESTHESIOLOGY

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Herpes Zoster Risk Factors in a National Cohort of Veterans with Rheumatoid Arthritis

(2009) Jay R. McDonald et al.   CLINICAL INFECTIOUS DISEASES

Disseminated Herpes Zoster Mimicking Rheumatoid Vasculitis in a Rheumatoid Arthritis Patient on Etanercept

(2009) S. Tresch et al.   DERMATOLOGY

Herpes virus-based recombinant herpes vectors: gene therapy for pain and molecular tool for pain science

(2009) D C Yeomans et al.   GENE THERAPY

A human trial of HSV-mediated gene transfer for the treatment of chronic pain

(2009) D Wolfe et al.   GENE THERAPY

AAV for pain: steps towards clinical translation

(2009) A S Beutler et al.   GENE THERAPY

Risk of Herpes Zoster in Patients With Rheumatoid Arthritis Treated With Anti–TNF-α Agents

(2009) Anja Strangfeld   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Recombinant Adeno-Associated Virus Serotype 6 (rAAV2/6)-Mediated Gene Transfer to Nociceptive Neurons through Different Routes of Delivery

(2009) Chris Towne et al.   Molecular Pain

Postherpetic neuralgia: From preclinical models to the clinic

(2009) Ada Delaney et al.   Neurotherapeutics

Tumour necrosis factor α mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1β, protein kinase C and cyclooxygenase-2 signalling

(2009) Fiona A. Russell et al.   PAIN

A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms

(2009) Ralf Baron et al.   PAIN

The Prevalence of Neuropathic Pain: Clinical Evaluation Compared with Screening Tools in a Community Population

(2009) Barbara P. Yawn et al.   PAIN MEDICINE

Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)

(2008) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

The impact of treatment with tumour necrosis factor-α antagonists on the course of chronic viral infections: a review of the literature

(2008) S. Domm et al.   BRITISH JOURNAL OF DERMATOLOGY

Effects of transgene-mediated endomorphin-2 in inflammatory pain

(2008) Shuanglin Hao et al.   EUROPEAN JOURNAL OF PAIN

Crucial roles of MZF-1 in the transcriptional regulation of apomorphine-induced modulation of FGF-2 expression in astrocytic cultures

(2008) Xiaoying Luo et al.   JOURNAL OF NEUROCHEMISTRY

Exogenous tumor necrosis factor-α rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn

(2008) Dong-ho Youn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Spinal Ceramide Modulates the Development of Morphine Antinociceptive Tolerance via Peroxynitrite-Mediated Nitroxidative Stress and Neuroimmune Activation

(2008) M. M. Ndengele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Gene Transfer of GLT-1, a Glial Glutamate Transporter, into the Spinal cord by Recombinant Adenovirus Attenuates Inflammatory and Neuropathic Pain in Rats

(2008) Sanae Maeda et al.   Molecular Pain

Gene therapy directed at the neuroimmune component of chronic pain with particular attention to the role of TNFα

(2008) Marina Mata et al.   NEUROSCIENCE LETTERS

Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain

(2008) Stephen J. Medhurst et al.   PAIN

Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain

(2008) B. Storek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA