Article
Behavioral Sciences
Shaghayegh Modaberi, Haleh Amirteymori, Somaye Mesgar, Kiarash Eskandari, Abbas Haghparast
Summary: This study examined the role of orexins and orexin receptors in the dentate gyrus (DG) region of the hippocampus in methamphetamine-induced conditioned place preference (CPP). The results showed that orexin receptors play a more critical role in the conditioning phase than in the expression phase.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Veronica Pastor, Fernando Castillo Diaz, Valeria C. Sanabria, Juliana F. Dalto, Marta C. Antonelli, Jorge H. Medina
Summary: The activation of ?7 nAChRs in the mPFC is necessary for the acquisition and retrieval of cocaine-associated memories, but not for consolidation. Inhibiting ?7 nAChRs may abolish cocaine-induced sensitization and prevent memory related to drug rewarding effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Zhi-yuan Wang, Liang-kun Guo, Xiao Han, Rui Song, Guo-ming Dong, Chun-ming Ma, Ning Wu, Jin Li
Summary: The study investigated the effects of naltrexone on the properties of incentive salience and reward-related memory in methamphetamine addiction using mouse models. Naltrexone was found to reduce methamphetamine-induced hyper locomotion and suppress the development of locomotor sensitization, suggesting its therapeutic potential in treating methamphetamine addiction. These findings demonstrate that naltrexone could intervene in the incentive salience and reward-related memory properties, contributing to its therapeutic effects on methamphetamine addicts in clinical studies.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Justin N. Siemian, Miguel A. Arenivar, Sarah Sarsfield, Cara B. Borja, Charity N. Russell, Yeka Aponte
Summary: Research shows that a subpopulation of LH GABAergic neurons expressing leptin receptors specifically drives appetitive behaviors in mice, while their ablation does not affect weight gain and food intake. Both groups of neurons in the LH can modulate reward-related behaviors, but only LHVGAT neurons impact feeding, and LHLEPR neurons can discriminate conditioned cues in Pavlovian paradigms.
Article
Behavioral Sciences
Ferdos Zamanirad, Mojdeh Fattahi, Haleh Amirteymori, Zahra Mousavi, Abbas Haghparast
Summary: Targeting the orexin system, particularly in the ventral tegmental area (VTA), has been shown to be a promising approach for treating drug addiction. Modulating the orexin system in the VTA can facilitate the extinction process of drug-related memories and prevent their relapse.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Shole Jamali, Shahram Zarrabian, Abbas Haghparast
Summary: The study demonstrated that Orx1Rs in the mPFC regulate the reward-related effects of morphine- and food-induced reward behaviors.
Article
Psychiatry
Arash Khanegheini, Masoumeh Khani, Shahram Zarrabian, Shahrokh Yousefzadeh-Chabok, Behrooz Khakpour Taleghani, Abbas Haghparast
Summary: The study looked at the potential interaction between CBD and METH during the sensitization phase on the rewarding effect of METH, with results indicating that CBD may reduce the motivation for METH seeking. Additionally, the study found that prior exposure to METH and the use of CBD could create sensitization to METH CPP even at sub-threshold doses of METH.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Laila Asth, Lia P. Iglesias, Rayssa C. Brianis, Anna P. Marcal, Nicia P. Soares, Daniele C. Aguiar, Fabricio A. Moreira
Summary: This study examined the effects of monoamine stabilizers and aripiprazole on cocaine-induced behaviors. The results showed that aripiprazole could prevent cocaine-induced hyperlocomotion, but also impaired spontaneous locomotion, while (-)-OSU6162 had a minor effect. (-)-OSU6162 also played a role in preventing the acquisition of cocaine-induced conditioned place preference.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Samah Shahen-Zoabi, Reem Smoum, Tehila Beiser, Alina Nemirovski, Raphael Mechoulam, Rami Yaka
Summary: This study investigates the impact of enhancing the endocannabinoid system (ECS) through exogenous administration of selective endocannabinoids on cocaine-induced behaviors. The findings suggest that boosting the ECS can attenuate cocaine-induced behaviors, providing potential benefits in the treatment of drug addiction.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ariana C. Brice-Tutt, Darrice S. Montgomery, Cassidy M. Kramer, Peter M. Novotny, Wendi L. Malphurs, Abhisheak Sharma, Robert. M. Caudle, Adriaan W. Bruijnzeel, Barry Setlow, John K. Neubert, Niall P. Murphy
Summary: This study found that there are inter-relationships between pain sensitivity, drug reward, and drug misuse. Rats were tested for pain sensitivity, conditioned place preference to oxycodone, and the impact of neuropathic pain on pain sensitivity and reinstatement of conditioned place preference. The results suggest that high rates of behavioral sensitization predict faster rates of extinction of oxycodone seeking/reward, and cutaneous thermal reflex pain may be predictive of both.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Meng-Jing Zhao, Mi-Ya Wang, Le Ma, Khalil Ali Ahmad, Yong-Xiang Wang
Summary: The study showed that BAA attenuated morphine-induced withdrawal symptoms, CPP expression, and locomotor sensitization by stimulating microglial dynorphin A expression in the brain. This suggests that BAA may be a potential candidate for treating opioids-induced physical dependence and addiction.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Behavioral Sciences
Matthias Linhardt, Dominik P. Kiser, Paul Pauli, Kirsten Hilger
Summary: This meta-analysis provides a systematic overview of the developing field of applying the conditioned place preference (CPP) paradigm in human research. The results indicate that CPP has great potential to study approach-avoidance behavior in humans, similar to animal studies. Guidelines for future CPP research are provided to improve comparability of studies and facilitate new insights into anxiety disorders and drug abuse.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Substance Abuse
Justin R. Yates, Hunter L. Campbell, Lauren L. Hawley, Matthew J. Horchar, Joy L. Kappesser, Makayla R. Wright
Summary: The study demonstrates that Ro 63-1908 is able to decrease the conditioned rewarding effects of methamphetamine, with varying effects observed in male and female rats.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Neurosciences
Mona Taghipour, Parviz Sabahi, Alireza Pooriamehr, Hossein Miladi-Gorji
Summary: This study found that swimming exercise during morphine abstinence before mating in parents-to-be can reduce morphine-induced preference and locomotor activity in pubertal rat offspring, potentially lowering the risk of opioid addiction.
NEUROSCIENCE LETTERS
(2021)
Review
Substance Abuse
Douglas Marques, Piter Kehoma Boll, Rosane Gomez, Eliane Dallegrave, Jose Inacio Lemos, Mirna Bainy-Leal
Summary: This systematic review aimed to predict the primary outcomes of alcohol-induced place conditioning in male outbred rats. The results showed that the interaction between alcohol dose and habituation sessions/trials predicted conditioning failure rates, while different conditions and characteristics of animals predicted CPA and CPP rates.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Neurosciences
Andrew D. Chang, Victoria A. Berges, Sunho J. Chung, Gene Y. Fridman, Jay M. Baraban, Irving M. Reti
NEUROPSYCHOPHARMACOLOGY
(2016)
Article
Behavioral Sciences
Ashley M. Blouin, JongAh J. Lee, Bo Tao, Dani R. Smith, Alexander W. Johnson, Jay M. Baraban, Irving M. Reti
BEHAVIOURAL BRAIN RESEARCH
(2013)
Article
Behavioral Sciences
Ashley M. Blouin, Anna L. Stern, Sungho Han, Florence R. Theberge, Chuansong Wang, Matthew J. During, Jay M. Baraban, Irving M. Reti
BEHAVIOURAL PHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Hamid Azzedine, Petra Zavadakova, Violaine Plante-Bordeneuve, Maria Vaz Pato, Nuno Pinto, Luca Bartesaghi, Jennifer Zenker, Olivier Poirot, Nathalie Bernard-Marissal, Estelle Arnaud Gouttenoire, Romain Cartoni, Alexandra Title, Giulia Venturini, Jean-Jacques Medard, Edward Makowski, Ludger Schoels, Kristl G. Claeys, Claudia Stendel, Andreas Roos, Joachim Weis, Odile Dubourg, Jose Leal Loureiro, Giovanni Stevanin, Gerard Said, Anthony Amato, Jay Baraban, Eric LeGuern, Jan Senderek, Carlo Rivolta, Roman Chrast
HUMAN MOLECULAR GENETICS
(2013)
Article
Veterinary Sciences
Irving M. Reti, Ashley M. Blouin, Paul F. Worley, Peter C. Holland, Alexander W. Johnson, Jay M. Baraban
Article
Cell Biology
Siu P. Ngok, Rory Geyer, Miaoliang Liu, Antonis Kourtidis, Sudesh Agrawal, Chuanshen Wu, Himabindu Reddy Seerapu, Laura J. Lewis-Tuffin, Karen L. Moodie, Deborah Huveldt, Ruth Marx, Jay M. Baraban, Peter Storz, Arie Horowitz, Panos Z. Anastasiadis
JOURNAL OF CELL BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Yen-Ching Wu, Rebecca Williamson, Zhi Li, Annalisa Vicario, Jerry Xu, Masataka Kasai, Yijuang Chern, Enrico Tongiorgi, Jay M. Baraban
JOURNAL OF NEUROCHEMISTRY
(2011)
Article
Immunology
M. Miskimon, S. Han, J. J. Lee, M. Ringkamp, M. A. Wilson, R. S. Petralia, X. Dong, P. F. Worley, J. M. Baraban, I. M. Reti
JOURNAL OF NEUROIMMUNOLOGY
(2014)
Article
Neurosciences
AlexanderW. Johnson, Sungho Han, Ashley M. Blouin, Jasjit Saini, Paul F. Worley, Matthew J. During, Peter C. Holland, Jay M. Baraban, Irving M. Reti
Article
Neurosciences
Ashley M. Blouin, Sungho Han, Anne M. Pearce, KaiLun Cheng, JongAh J. Lee, Alexander W. Johnson, Chuansong Wang, Matthew J. During, Peter C. Holland, Yavin Shaham, Jay M. Baraban, Irving M. Reti
Article
Neurosciences
Akiko Hayashi-Takagi, Manabu Takaki, Nick Graziane, Saurav Seshadri, Hannah Murdoch, Allan J. Dunlop, Yuichi Makino, Anupamaa J. Seshadri, Koko Ishizuka, Deepak P. Srivastava, Zhong Xie, Jay M. Baraban, Miles D. Houslay, Toshifumi Tomoda, Nicholas J. Brandon, Atsushi Kamiya, Zhen Yan, Peter Penzes, Akira Sawa
NATURE NEUROSCIENCE
(2010)
Article
Neurosciences
Risheng Xu, Anthony V. Serritella, Tanusree Sen, Justin M. Farook, Thomas W. Sedlak, Jay Baraban, Solomon H. Snyder, Nilkantha Sen
Article
Neurosciences
Mitsuru Ishikawa, Jun Shiota, Yuta Ishibashi, Tomoyuki Hakamata, Shizuku Shoji, Mamoru Fukuchi, Masaaki Tsuda, Tomoaki Shirao, Yuko Sekino, Jay M. Baraban, Akiko Tabuchi
Article
Cell Biology
Ken Asada, Emanuele Canestrari, Xiuping Fu, Zhi Li, Edward Makowski, Yen-Ching Wu, Jeffrey K. Mito, David G. Kirsch, Jay Baraban, Zain Paroo
Article
Biochemistry & Molecular Biology
Mitsuru Ishikawa, Jun Shiota, Yuta Ishibashi, Tomoyuki Hakamata, Shizuku Shoji, Mamoru Fukuchi, Masaaki Tsuda, Tomoaki Shirao, Yuko Sekino, Toshihisa Ohtsuka, Jay M. Baraban, Akiko Tabuchi