Review
Cell Biology
Ian James Bell, Matthew Sheldon Horn, Terence John Van Raay
Summary: The non-canonical Wnt signaling pathways have different roles in cancer and development, involving calcium and Vangl2. Cells tend to choose non-canonical Wnt signaling over canonical Wnt signaling when presented with a choice, but this occurs rarely in vivo.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gang Chen, Danyun Xu, Qing Liu, Zhichuang Yue, Biao Dai, Shujuan Pan, Yongqiang Chen, Xinhua Feng, Honghong Hu
Summary: The nuclear import of FLC during floral transition is mediated by the NUP62-subcomplex, which includes nucleoporins NUP62, NUP58, and NUP54, in an importin & alpha;-independent manner. The carrier protein SAD2 is critical for FLC nuclear import and flower transition mainly through the NUP62-subcomplex, which mediates the import of cargos with unconventional NLSs, including FLC.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jae Young Shin, Jaeyoon Kim, Yun-Ho Choi, Sanghwa Lee, Nae-Gyu Kang
Summary: This study found that escin can stimulate the Wnt/β-catenin signaling pathway in cultured human dermal papilla cells, resulting in increased β-catenin and LEF1 expression, accumulation of nuclear β-catenin, and enhanced expression of Wnt target genes. Additionally, escin downregulates GSK-3β protein expression by facilitating its proteasomal degradation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang
Summary: The loss of NFIX gene affects endochondral ossification and mineralization in bone, with NFIX inducing osteoblast differentiation and impairing adipocyte formation by regulating HMGA1 expression. HMGA1 plays a role in osteoblast commitment and mediates NFIX function by activating canonical Wnt signaling pathways.
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Environmental Sciences
Saifang Fu, Rongbang Tan, Yufei Feng, Ping Yu, Yuqian Mo, Wei Xiao, Shouyu Wang, Jingjing Zhang
Summary: This study revealed that N-methyl-N-nitrosourea (MNU) induced aberrant angiogenesis through the modulation of the rspo1/Wnt/β-catenin/vegfaa axis. Furthermore, it was found that the pro-angiogenic effect of MNU on developing zebrafish embryos could be controlled through pharmacological manipulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Jingjing Fa, Xiaoqing Zhang, Xiaoping Zhang, Ming Qi, Xingyu Zhang, Qihua Fu, Zhuoming Xu, Yunqian Gao, Bo Wang
Summary: Congenital heart defects are the most common birth defects worldwide, with 22q11.2 deletion syndrome often associated with conotruncal malformations. A study revealed that the lncRNA lnc-TSSK2-8 plays a significant role in cardiac outflow tract development, activating the canonical Wnt/beta-catenin signaling pathway, potentially contributing to the etiology of CNV-related CHD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Cen-Shan Lin, Yuyi Liang, Shu-Guang Su, Yin-Li Zheng, Neng Jiang, Jing Zhou, Ying Zhang, Ru Deng, Chun-Hua Wang, Shi-Xun Lu, Yu-Hua Huang, Li-Li Liu, Chao Zhang, Jing-Ping Yun
Summary: The study identified elevated Nup93 expression in HCC tissues, especially in cases with metastasis, and its association with poorer prognosis. Nup93 was found to promote HCC metastasis and proliferation by regulating beta-catenin translocation, while the interaction between Nup93 and beta-catenin, as well as a positive feedback loop involving LEF1 and beta-catenin, further facilitated metastasis and proliferation in HCC. The findings suggest potential therapeutic targets in the LEF1-Nup93-beta-catenin pathway for HCC treatment.
Article
Microbiology
Chongyang Wang, Ruochen Hu, Liuyuan Duan, Qili Hou, Mengqing Yang, Ting Wang, Haijin Liu, Sa Xiao, Ruyi Dang, Juan Wang, Xinglong Wang, Shuxia Zhang, Zengqi Yang
Summary: This study showed that pseudorabies virus (PRV) infection activates the Wnt/beta-catenin signaling pathway, leading to enhanced virus proliferation and regulation of virus-induced autophagy. Inhibitors of this pathway can reduce PRV titers, while stimulation of the pathway can enhance PRV proliferation. These findings provide potential targets for the development of antiviral agents against PRV.
VETERINARY MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaopan Gao, Huabin Tian, Kaixiang Zhu, Qing Li, Wei Hao, Linyue Wang, Bo Qin, Hongyu Deng, Sheng Cui
Summary: This study reveals the molecular basis for the antagonistic function of Sarbecovirus ORF6 and suggests a potential strategy for immunosuppressive drug development using ORF6 CTT-derived peptides.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Qi Zhou, Shengyu Lyu, Anthony A. Bertrand, Allison C. Hu, Candace H. Chan, Xiaoyan Ren, Marley J. Dewey, Aleczandria S. Tiffany, Brendan A. C. Harley, Justine C. Lee
Summary: By comparing noncrosslinked (NX-MC) and crosslinked (MC) forms of MC-GAG, this study evaluated the impact of stiffness on osteogenicity, finding that increasing stiffness can induce osteogenic differentiation through YAP/TAZ and the canonical Wnt signaling pathway, while activation of the canonical BMPR signaling pathway is independent of stiffness.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Article
Peripheral Vascular Disease
Irena Kasacka, Zaneta Piotrowska, Natalia Domian, Magdalena Acewicz, Alicja Lewandowska
Summary: The study revealed alterations in Wnt/beta-catenin signaling in the kidneys of rats during hypertension, with the severity of these changes depending on the type of hypertension. This study is the first to assess the levels of some elements of the canonical Wnt/beta-catenin signal transduction pathway in various types of arterial hypertension by immunohistochemistry, and may lead to further molecular and functional studies of this pathway in hypertension.
HYPERTENSION RESEARCH
(2021)
Article
Cell & Tissue Engineering
Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen, Liaobin Chen
Summary: This study demonstrates the ability of Morusin to promote osteogenic differentiation of BMSCs through activation of the Wnt/β-catenin signaling pathway, and suggests the potential of Morusin as a treatment for osteoporosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Long Chen, Meilin Zhang, Yi Ding, Min Li, Jinjie Zhong, Shumei Feng
Summary: Fluoride promotes proliferation and differentiation of osteoblasts through the BMP2-Wnt/beta-catenin axis, providing a theoretical basis for the treatment of skeletal fluorosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Shu Meng, Gang Zhou, Qilin Gu, Palas K. Chanda, Frank Ospino, John P. Cooke
CIRCULATION RESEARCH
(2016)
Article
Engineering, Electrical & Electronic
Qi-Lin Gu, Peng Zhang, Yi Ru, Hao Song, Wen-Sheng Zhao, Wen-Yan Yin
MICROELECTRONICS RELIABILITY
(2017)
Article
Cardiac & Cardiovascular Systems
Shu Meng, Qilin Gu, Xiaojie Yang, Jie Lv, Iris Owusu, Gianfranco Matrone, Kaifu Chen, John P. Cooke, Longhou Fang
Article
Cell Biology
Quan Sun, Kang-Kai Wang, Miao Pan, Ji-Peng Zhou, Xue-Ting Qiu, Zhen-Yu Wang, Zhen Yang, Yan Chen, Hong Shen, Qi-Lin Gu, Long-Hou Fang, Guo-Gang Zhang, Yong-Ping Bai
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Multidisciplinary Sciences
Qiaomei Sun, Qilin Gu, Kongjun Zhu, Rongying Jin, Jinsong Liu, Jing Wang, Jinhao Qiu
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Qilin Gu, Xiaojie Yang, Jie Lv, Jiaxiong Zhang, Bo Xia, Jun-dae Kim, Ruoyu Wang, Feng Xiong, Shu Meng, Thomas P. Clements, Bhavna Tandon, Daniel S. Wagner, Miguel F. Diaz, Pamela L. Wenzel, Yury I. Miller, David Traver, John P. Cooke, Wenbo Li, Leonard I. Zon, Kaifu Chen, Yongping Bai, Longhou Fang
Article
Cell Biology
Xiaojie Yang, Xixi Li, Qilin Gu, Qing Li, Zongbin Cui
Correction
Multidisciplinary Sciences
Jie Lv, Shu Meng, Qilin Gu, Rongbin Zheng, Xinlei Gao, Jun-dae Kim, Min Chen, Bo Xia, Yihan Zuo, Sen Zhu, Dongyu Zhao, Yanqiang Li, Guangyu Wang, Xin Wang, Qingshu Meng, Qi Cao, John P. Cooke, Longhou Fang, Kaifu Chen, Lili Zhang
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jie Lv, Shu Meng, Qilin Gu, Rongbin Zheng, Xinlei Gao, Jun-dae Kim, Min Chen, Bo Xia, Yihan Zuo, Sen Zhu, Dongyu Zhao, Yanqiang Li, Guangyu Wang, Xin Wang, Qingshu Meng, Qi Cao, John P. Cooke, Longhou Fang, Kaifu Chen, Lili Zhang
Summary: A comprehensive understanding of the lineage specification of endothelial cells is crucial for cardiovascular regenerative medicine. Recent studies have revealed the preferential regulation of cell identity genes by unique epigenetic signatures. In this study, we investigated the epigenetic landscape of endothelial cell lineage and identified MECOM as a key regulator.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Shu Meng, Qilin Gu, Xiaojie Yang, Jie Lv, Iris Owusu, Gianfranco Matrone, Kaifu Chen, Longhou Fang, John Cooke
Article
Hematology
Gianfranco Matrone, Shu Meng, Qilin Gu, Jie Lv, Longhou Fang, Kaifu Chen, John P. Cooke
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Renfang Mao, Shu Meng, Qilin Gu, Raquel Araujo-Gutierrez, Sandeep Kumar, Qing Yan, Felicidad Almazan, Keith A. Youker, Yingbin Fu, Henry J. Pownall, John P. Cooke, Yury I. Miller, Longhou Fang
CIRCULATION RESEARCH
(2017)
Article
Chemistry, Physical
Bing Feng, Zhengying Wu, Jinsong Liu, Kongjun Zhu, Ziquan Li, Xin Jin, Yindi Hou, Qingyang Xi, Mengqi Cong, Pengcheng Liu, Qilin Gu
APPLIED CATALYSIS B-ENVIRONMENTAL
(2017)