Article
Chemistry, Medicinal
Rui Guo, Ya-Tian Meng, Xiao-Juan Cao, Cun-Lin Wang, Xin Qiao, Qiong Zhang
Summary: Four new tirucallane-type triterpenoids (1-4) and four known analogues (5-8) were isolated from Melia toosendan Sieb. et Zucc. fruits. Their structures were determined using HRESIMS, 1D and 2D NMR spectroscopy. The relative configurations of 1-4 were confirmed by NOESY experiments, and the absolute configurations were established by comparing experimental and calculated ECD spectra. Compound 4 and 5 exhibited moderate α-glucosidase inhibitory activities with IC50 values of 120.3 +/- 5.8 and 104.9 +/- 7.1 μM, respectively.
Article
Chemistry, Medicinal
Akiko Kawasaki, Hiroshi Hashimoto, Yoshie Shimotoyodome, Shotaro Ito, Junko Ishikawa, Yoshiya Sugai, Taketoshi Fujimori
Summary: This study identified limonoids such as toosendanin and hydroxylated unsaturated fatty acids as the major active components in Melia toosendan fruit extracts that can increase ceramide levels in the skin. It also showed for the first time that limonoids promote ceramide production in skin cells, suggesting the potential of Melia toosendan fruit extracts for developing products to improve skin barrier function.
Article
Food Science & Technology
Wen Xia, Ersheng Gong, Yanyun Lin, Tong Li, Fengli Lian, Bisheng Zheng, Rui Hai Liu
Summary: The study found that Chinese bayberry pulp extracts are rich in total phenolics and total flavonoids, displaying high antioxidant and antiproliferative activities. Wild pink bayberry showed the highest antioxidant and antiproliferative activities among the four varieties examined.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Forestry
Qianqian Li, Jin Huang, Xue Yang, Zarmina Gul, Wenxue Sun, Bin Qiao, Jiabo Cheng, Chunying Li, Chunjian Zhao
Summary: Our research group successfully designed a mixed forest of F. carica and Taxus cuspidata Sieb. et Zucc, and confirmed their stable interspecific relationship and the promoting effect of F. carica on the growth of neighboring T. cuspidata. However, the specific promoting mechanism has not been elucidated.
Article
Agricultural Engineering
Chang Ha Park, Ramaraj Sathasivam, Tae Jin Kim, Byung Bae Park, Jae Kwang Kim, Sang Un Park
Summary: Cornus officinalis is a valuable medicinal plant with various medicinal properties. This study analyzed the primary and secondary metabolites in different developmental stages of the fruit and found significant changes in their composition and content during fruit development.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biodiversity Conservation
Xiangguang Duan, Zhiyuan Jia, Junqing Li, Shuhong Wu
Summary: Trait-based approaches have been widely used to understand plant adaptation mechanisms. This study investigated the relationships between leaf functional traits and environmental factors in Pinus densiflora. The results showed that leaf nitrogen content was positively correlated with mean annual precipitation, while leaf area was positively correlated with mean annual temperature. Climate was found to be the main driving factor for the variation of leaf functional traits.
GLOBAL ECOLOGY AND CONSERVATION
(2022)
Review
Chemistry, Applied
Yangyang Zhang, Yuze Li, Shiqi Huang, Yuwen Cui, Huawei Zhang, Wenli Huang, Chong Deng, Wei Wang, Xiaomei Song
Summary: Two new pregnane alkaloids and four known alkaloids were isolated from Pachysandra terminalis Sieb. et Zucc. The new compound exhibited moderate cytotoxicity against certain tumor cell lines, while the known alkaloids showed weak cytotoxic activity.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Qingqing Yang, Zhirong Wang, Xuhui Chen, Zehang Guo, Leyan Wen, Jianquan Kan
Summary: This study used untargeted metabolomics to comprehensively detect the metabolites in Zanthoxylum schinifolium Sieb. et Zucc. and screened 53 potential bitter metabolites. Thirteen bitter compounds were obtained through sensory-guided fractionation and UPLC-Q-TOF-MS characterization. Among them, quercetin, isorhamnetin and kaempferol had particularly low thresholds and high contents, significantly contributing to the bitterness of Zanthoxylum schinifolium Sieb. et Zucc. This study provides a reliable theoretical basis for future research on bitterness mechanisms.
Review
Biochemistry & Molecular Biology
Haifeng Zhang, Kun Teng, Hao Zang
Summary: Actinidia arguta, a highly valued vine plant, is extensively used for its edible and medicinal properties. Its various parts serve different purposes and contain a wide array of active ingredients. Flavonoids, phenolics, alkaloids, and polysaccharides are the key bioactive constituents of A. arguta, exhibiting remarkable antioxidant, anti-inflammatory, and anti-tumor properties. Further research is necessary to enhance understanding of its mechanism of action and quality evaluation, and to explore its potential applications in anti-aging and anti-tumor drug research and development.
Article
Food Science & Technology
Shan Huang, Lu Wang, Zhirong Wang, Gang Yang, Xuwen Xiang, Yuanzhe An, Jianquan Kan
Summary: Metabolomics and transcriptomic analysis were used to identify key bitter components and biosynthetic pathways in the development of Zanthoxylum schinifolium. The main sources of bitterness in mature Z. schinifolium were determined through taste activity value evaluation. These findings provide valuable information for understanding the bitterness mechanism of Z. schinifolium and promoting its further development.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Plant Sciences
Xiao Huang, Zhaojun Ni, Ting Shi, Ryutaro Tao, Qin Yang, Changguo Luo, Yongping Li, Hantao Li, Haidong Gao, Xiangyang Zhou, Lei Xu, Zhihong Gao
Summary: This study investigated the genetic diversity and population structure of Japanese apricots in different regions of China and Japan. The results showed high genetic diversity in both wild and cultivated populations in China, with small impact from artificial selection. The chloroplast genome analysis revealed the dissemination routes of Japanese apricot, including the Yangtze River basin and Pearl River basin, and the origin of Japanese-bred accessions in Zhejiang, China.
Article
Food Science & Technology
Shenglan Liao, Gang Yang, Yuheng Ou, Shan Huang, Bin Li, Aijun Li, Jianquan Kan
Summary: Zanthoxylum schinifolium Sieb. et Zucc essential oil (ZEO) exhibited strong antibacterial activity against Staphylococcus epidermidis by damaging the cell membrane and disrupting the normal physiological function. It also disrupted the homeostasis of reactive oxygen species, leading to oxidative damage to the cells. ZEO has the potential to be developed as an antimicrobial agent against S. epidermidis.
Article
Microbiology
Junho Lee, Hee Kyoung Kang, Hyeonsook Cheong, Yoonkyung Park
Summary: Pine needles contain functional components with antioxidant, antimicrobial, anti-diabetic, and anti-inflammatory activities. Novel antimicrobial peptides isolated from Pinus densiflora Sieb. et Zucc. showed antimicrobial activity against foodborne bacteria without hemolytic activity or cytotoxicity, suggesting potential applications in the food industry.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Meng Yang, Zhiyou Hao, Xiaolan Wang, Shiqi Zhou, Chaoyuan Xian, Denghui Zhu, Ying Yang, Junjun Wei, Xiaoke Zheng, Weisheng Feng
Summary: Four novel iridoid glycosides and nine known ones were isolated from Cornus officinalis fruits. These compounds exhibited antidiabetic activities in insulin-resistant HepG2 cells.
Article
Plant Sciences
Xiaopeng Ni, Zhaojun Ni, Kenneth Omondi Ouma, Zhihong Gao
Summary: This study investigates the molecular mechanism underlying fruit color variation in Japanese apricot, identifying a key gene PmUFGT3 associated with anthocyanin biosynthesis. The study confirms the function of PmUFGT3 and demonstrates the potential for genetic engineering to alter fruit color.
Article
Medicine, General & Internal
Jing Quan, Yu-jie Gao, Zai-lin Yang, Hui Chen, Jing-rong Xian, Shuai-shuai Zhang, Qin Zou, Ling Zhang
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2015)
Article
Biochemistry & Molecular Biology
Jingrong Xian, Huiyuan Shao, Xianchun Chen, Shuaishuai Zhang, Jing Quan, Qin Zou, Hongjun Jin, Ling Zhang
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2016)
Article
Oncology
Qin Zou, Shi Tan, Zailin Yang, Juan Wang, Jingrong Xian, Shuaishuai Zhang, Hongjun Jin, Liyuan Yang, Lu Wang, Ling Zhang
Article
Oncology
Shuaishuai Zhang, Fengxian Qin, Liyuan Yang, Jingrong Xian, Qin Zou, Hongjun Jin, Lu Wang, Ling Zhang
Article
Medicine, Research & Experimental
Qin Zou, Shi Tan, Zailin Yang, Qian Zhan, Hongjun Jin, Jingrong Xian, Shuaishuai Zhang, Liyuan Yang, Lu Wang, Ling Zhang
Article
Oncology
Hongjun Jin, Liyuan Yang, Lu Wang, Zailin Yang, Qian Zhan, Yao Tao, Qin Zou, Yuting Tang, Jingrong Xian, Shuaishuai Zhang, Yipei Jing, Ling Zhang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Huijuan Zhang, Shi Tan, Juan Wang, Shana Chen, Jing Quan, Jingrong Xian, Shuai Shuai Zhang, Jingang He, Ling Zhang
EXPERIMENTAL CELL RESEARCH
(2014)
Article
Medicine, General & Internal
Feng-Xian Qin, Hui-Yuan Shao, Xian-Chun Chen, Shi Tan, Hui-Juan Zhang, Zong-Yu Miao, Li Wang, Hui-Chen, Ling Zhang
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2011)
Article
Biochemistry & Molecular Biology
Yuting Tang, Yao Tao, Lu Wang, Liyuan Yang, Yipei Jing, Xueke Jiang, Li Lei, Zailin Yang, Xin Wang, Meixi Peng, Qiaoling Xiao, Jun Ren, Ling Zhang
Summary: The study revealed the interaction between NPM1 mutant and ULK1, demonstrating that NPM1 mutant maintains autophagic cell survival by regulating ULK1 stability and activation. This extends our understanding of the role of NPM1 mutant in autophagy activation in NPM1-mutated AML.
Article
Oncology
Yipei Jing, Xueke Jiang, Li Lei, Meixi Peng, Jun Ren, Qiaoling Xiao, Yao Tao, Yonghong Tao, Junpeng Huang, Lu Wang, Yuting Tang, Zailin Yang, Zesong Yang, Ling Zhang
Summary: Our study investigated the functional and mechanistic roles of the lncRNA HOTAIRM1 in NPM1-mutated AML. We found that HOTAIRM1 is highly expressed in NPM1-mutated AML and is induced in part by mutant NPM1 through KLF5-dependent transcriptional regulation. Importantly, HOTAIRM1 promotes autophagy and proliferation both in vitro and in vivo, acting as a scaffold for EGR1 degradation in the nucleus and as a sponge for miR-152-3p to increase ULK3 expression in the cytoplasm. Overall, our findings suggest that HOTAIRM1 may be a promising therapeutic target for this distinct leukemia subtype.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Qiaoling Xiao, Li Lei, Jun Ren, Meixi Peng, Yipei Jing, Xueke Jiang, Junpeng Huang, Yonghong Tao, Can Lin, Jing Yang, Minghui Sun, Lisha Tang, Xingyu Wei, Zailin Yang, Ling Zhang
Summary: This study found decreased levels of m(6)A RNA modification in acute myeloid leukemia (AML) with nucleophosmin 1 (NPM1) mutations. The high expression of fat mass and obesity-associated protein (FTO) was responsible for the suppression of m(6)A modification. FTO upregulation facilitated leukemic cell survival through activating the PDGFRB/ERK signaling axis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Meixi Peng, Jun Ren, Yipei Jing, Xueke Jiang, Qiaoling Xiao, Junpeng Huang, Yonghong Tao, Li Lei, Xin Wang, Zailin Yang, Zesong Yang, Qian Zhan, Can Lin, Guoxiang Jin, Xian Zhang, Ling Zhang
Summary: In patients with NPM1-mutated AML, leukemic cells release miR-19a-3p through sEVs to suppress the immune function of CD8+ T cells by inhibiting creatine import mediated by SLC6A8. This immune evasion mechanism may serve as a promising therapeutic target for NPM1-mutated AML.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Biochemistry & Molecular Biology
Yao Tao, Yuting Tang, Zailin Yang, Futao Wu, Lu Wang, Liyuan Yang, Li Lei, Yipei Jing, Xueke Jiang, Hongjun Jin, Yao Bai, Ling Zhang
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Lu Wang, Liyuan Yang, Zailin Yang, Yuting Tang, Yao Tao, Qian Zhan, Li Lei, Yipei Jing, Xueke Jiang, Hongjun Jin, Qin Zou, Jingrong Xian, Ling Zhang
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Oncology
Liyuan Yang, Lu Wang, Zailin Yang, Hongjun Jin, Qin Zou, Qian Zhan, Yuting Tang, Yao Tao, Li Lei, Yipei Jing, Xueke Jiang, Ling Zhang