Journal
JOURNAL OF NATURAL MEDICINES
Volume 73, Issue 4, Pages 697-705Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-019-01320-9
Keywords
Natural products; Screening; Wnt; Plants
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Funding
- KAKENHI grants from the Japan Society for the Promotion of Science [17H03992, 26305001]
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Wnt signaling has been implicated in numerous aspects of development, cell biology, and physiology. When aberrantly activated, Wnt signaling can also lead to the formation of tumors. Thus, Wnt signaling is an attractive target for cancer therapy. Based on our screening program targeting Wnt signaling activity using a cell-based luciferase screening system assessing TCF/beta-catenin transcriptional activity, we isolated a series of terpenoids and heterocyclic aromatic compounds that affect the Wnt signaling pathway at different points. Here, we describe our recent results in screening for natural products that inhibit or activate Wnt signaling.
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