Journal
PATHOLOGY & ONCOLOGY RESEARCH
Volume 17, Issue 4, Pages 955-963Publisher
SPRINGER
DOI: 10.1007/s12253-011-9409-4
Keywords
beta-catenin; E-cadherin; Wnt-1; Wnt signaling pathway; Advanced colorectal carcinoma; Prognostic factor
Funding
- Military Institute of the Health Services in Warsaw, Poland
- Celon Pharma Ltd.
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Wnt/beta-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, beta-catenin and Wnt-1 proteins in colorectal tumors. Expression of beta-catenin, E-cadherin and Wnt-1 was determined by immunohistochemistry on advanced colorectal cancers. Abnormal expression of E-cadherin, beta-catenin, Wnt-1 was observed. Additionally, we revealed correlations between levels of studied proteins and histoclinical data. In multivariate analysis nuclear beta-catenin, higher carcinoembryonic antigen serum level before treatment, female sex and tumor localized in colon or rectum were independent unfavorable prognostic factors. These findings support the hypothesis that Wnt/beta-catenin pathway plays an important role in advanced colorectal carcinoma.
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