Discovery of small molecule inhibitors of the Wnt/β-catenin signaling pathway by targeting β-catenin/Tcf4 interactions

Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction

(2016) Qinghao Zhang et al.   PLoS One

CWP232228 targets liver cancer stem cells through Wnt/β‑catenin signaling: a novel therapeutic approach for liver cancer treatment

(2016) Ji‑Young Kim et al.   Oncotarget

Wnt Signaling in Cancer Stem Cell Biology

(2016) Felipe de Sousa e Melo et al.   Cancers

Wnt/ -Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells

(2015) G.-B. Jang et al.   CANCER RESEARCH

A Small-Molecule Antagonist of the  -Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis

(2015) L. Fang et al.   CANCER RESEARCH

Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction through the Optimization of the Acyl Hydrazone Moiety

(2015) J. Leon Catrow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Targeting the Tcf4 G13ANDE17 Binding Site To Selectively Disrupt β-Catenin/T-Cell Factor Protein–Protein Interactions

(2013) Zheng Huang et al.   ACS Chemical Biology

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with β-Catenin/TCF4 Interaction in Colorectal Cancer Cells

(2013) Xingyao Li et al.   PLoS One

High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein–Protein Interactions

(2013) Min Zhang et al.   ACS Medicinal Chemistry Letters

Rational Design of Small-Molecule Inhibitors for β-Catenin/T-Cell Factor Protein–Protein Interactions by Bioisostere Replacement

(2012) Binxun Yu et al.   ACS Chemical Biology

Virtual Screening Methods as Tools for Drug Lead Discovery from Large Chemical Libraries

(2012) X. H. Ma et al.   CURRENT MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of New Diaminoquinazolines as β-Catenin/Tcf4 Pathway Inhibitors

(2012) Yongjun Mao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction

(2011) Wang Tian et al.   BIOCHEMISTRY

A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis

(2011) Wei Wang et al.   CELL RESEARCH

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

(2011) F. C. Gonsalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Updated Overview on Wnt Signaling Pathways

(2010) Tata Purushothama Rao et al.   CIRCULATION RESEARCH

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

Inhibition of β-catenin/Tcf signaling by flavonoids

(2010) Seyeon Park et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin

(2010) E Lavergne et al.   ONCOGENE

2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer

(2009) Zecheng Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and Synthesis of Novel Diaminoquinazolines within VivoEfficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition

(2009) Christoph M. Dehnhardt et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Bcl-w promoter is activated by β-catenin/TCF4 in human colorectal carcinoma cells

(2008) Abigail Lapham et al.   GENE

Crystal Structure of a Full-Length β-Catenin

(2008) Yi Xing et al.   STRUCTURE

Terminal Regions of β-Catenin Come into View

(2008) Cara J. Gottardi et al.   STRUCTURE