Naturally occurring compounds acting as potent anti-metastatic agents and their suppressing effects on Hedgehog and WNT/β-catenin signalling pathways

Nanotechnology for the delivery of phytochemicals in cancer therapy

(2016) Jing Xie et al.   BIOTECHNOLOGY ADVANCES

Metastasis: new functional implications of platelets and megakaryocytes

(2016) Raphael Leblanc et al.   BLOOD

Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?

(2016) Maren Diepenbruck et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway

(2016) Yunes Panahi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth

(2016) Peipei Duan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dietary flavonoid fisetin for cancer prevention and treatment

(2016) Rahul K. Lall et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Epithelial–mesenchymal transition: a new target in anticancer drug discovery

(2016) Fabrizio Marcucci et al.   NATURE REVIEWS DRUG DISCOVERY

Active ingredients leading in health claims on functional foods

(2016) Alie de Boer et al.   Journal of Functional Foods

Flavonoids in Inflammatory Bowel Disease: A Review

(2016) Teresa Vezza et al.   Nutrients

Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells

(2016) Jisun Oh et al.   Toxins

Molecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells

(2015) Verline Justilien et al.   CLINICAL CANCER RESEARCH

Downregulation of Wnt signaling by sonic hedgehog activation promotes repopulation of human tumor cell lines

(2015) J. Ma et al.   Disease Models & Mechanisms

SNAIL-induced epithelial-to-mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression

(2015) Daniel J. McGrail et al.   FASEB JOURNAL

Activation of TGF-β-induced non-Smad signaling pathways during Th17 differentiation

(2015) Maruf Hasan et al.   IMMUNOLOGY AND CELL BIOLOGY

Hedgehog signaling: From basic research to clinical applications

(2015) Erica Yao et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate cells

(2015) Naqi Lian et al.   LABORATORY INVESTIGATION

Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer

(2015) Asha Srinivasan et al.   MOLECULAR CARCINOGENESIS

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

When signals cross

(2015) Andrea Du Toit   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

(2015) Mark A. Feitelson et al.   SEMINARS IN CANCER BIOLOGY

Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development

(2015) Sergei Y. Sokol   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structural determinants of Smad function in TGF-β signaling

(2015) Maria J. Macias et al.   TRENDS IN BIOCHEMICAL SCIENCES

The emerging molecular machinery and therapeutic targets of metastasis

(2015) Yutong Sun et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened

(2015) Annelies Gonnissen et al.   Oncotarget

Genistein and Cancer: Current Status, Challenges, and Future Directions

(2015) Carmela Spagnuolo et al.   Advances in Nutrition

A new paradigm for tumor immune escape: β-catenin-driven immune exclusion

(2015) Stefani Spranger et al.   Journal for ImmunoTherapy of Cancer

Green tea polyphenol EGCG suppresses Wnt/β-catenin signaling by promoting GSK-3β- and PP2A-independent β-catenin phosphorylation/degradation

(2014) Sangtaek Oh et al.   BIOFACTORS

Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells

(2014) Wei Li et al.   Chinese Journal of Integrative Medicine

Curcumin as a cancer chemotherapy sensitizing agent

(2014) Youngjoo Kwon   Journal of the Korean Society for Applied Biological Chemistry

The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

(2014) Juli J. Unternaehrer et al.   Stem Cell Reports

Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion

(2013) Hildegonda P.H. Naber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vascular permeability changes involved in tumor metastasis

(2013) Jonathan García-Román et al.   CANCER LETTERS

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

An Apple Oligogalactan Potentiates the Growth Inhibitory Effect of Celecoxib on Colorectal Cancer

(2013) Yuhua Li et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness

(2012) Ester Sánchez-Tilló et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tumor stroma as targets for cancer therapy

(2012) Jing Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Resveratrol Impairs the Release of Steroid-resistant Cytokines from Bacterial Endotoxin-Exposed Alveolar Macrophages in Chronic Obstructive Pulmonary Disease

(2011) Jürgen Knobloch et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Flavonoids: Potential Wnt/beta-catenin signaling modulators in cancer

(2011) Nathália G. Amado et al.   LIFE SCIENCES

Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment

(2011) Purusotam Basnet et al.   MOLECULES

Resveratrol Inhibits Mucin Gene Expression, Production and Secretion From Airway Epithelial Cells

(2011) Su Yel Lee et al.   PHYTOTHERAPY RESEARCH

1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1

(2010) Pavlo L Kovalenko et al.   BMC GENOMICS

Significance of E-cadherin expression in triple-negative breast cancer

(2010) S Kashiwagi et al.   BRITISH JOURNAL OF CANCER

Common Botanical Compounds Inhibit the Hedgehog Signaling Pathway in Prostate Cancer

(2010) A. Slusarz et al.   CANCER RESEARCH

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

(2010) Muh-Hwa Yang et al.   CELL CYCLE

Targeting Hedgehog -- a Cancer Stem Cell Pathway

(2010) A. A. Merchant et al.   CLINICAL CANCER RESEARCH

(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells

(2010) Guo-Qing Tang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Antiproliferative Effects of Apple Peel Extract Against Cancer Cells

(2010) Shannon Reagan-Shaw et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1and Survivin Expression through Wnt/β-Catenin Signaling Pathway

(2009) Bao-En Shan et al.   CANCER INVESTIGATION

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Cellular signaling perturbation by natural products

(2009) Fazlul H. Sarkar et al.   CELLULAR SIGNALLING

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells

(2009) Pay-Chin Leow et al.   INVESTIGATIONAL NEW DRUGS

Inhibition of suicidal erythrocyte death by resveratrol

(2009) Syed M. Qadri et al.   LIFE SCIENCES

Lycopene Effects Contributing to Prostate Health

(2009) Karin Wertz   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Macrophage-derived IL-1β stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3

(2009) P Kaler et al.   ONCOGENE

Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds

(2009) Kavita Bisht et al.   TOXICOLOGY

Curcumin and cancer: An “old-age” disease with an “age-old” solution

(2008) Preetha Anand et al.   CANCER LETTERS

Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates  -catenin signaling in mammary epithelial cells

(2008) Y. Su et al.   CARCINOGENESIS

Regulation of Akt/FOXO3a/GSK-3β/AR Signaling Network by Isoflavone in Prostate Cancer Cells

(2008) Yiwei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt and Hedgehog Signaling Pathways in Bone Development

(2008) Timothy F. Day et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

The modulation of endothelial cell gene expression by green tea polyphenol-EGCG

(2008) Liping Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling

(2008) Steven Hoseong Yang et al.   NATURE GENETICS

Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries ofAronia melanocarpa, seeds of grape and bark ofYucca schidigerain vitro

(2008) Beata Olas et al.   PLATELETS

(Pro-)vitamin D as treatment option for hedgehog-related malignancies

(2007) Maarten F. Bijlsma et al.   MEDICAL HYPOTHESES