Applicability of organ-on-chip systems in toxicology and pharmacology

Reconstituted Human Organ Models as a Translational Tool for Human Organ Response: Definition, Expectations, Cases, and Strategies for Implementation in Drug Discovery and Development

(2020) Kazuhiro Tetsuka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Lung-on-a-chip: the future of respiratory disease models and pharmacological studies

(2020) Jesus Shrestha et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Quantitative adverse outcome pathway (qAOP) models for toxicity prediction

(2020) Nicoleta Spinu et al.   ARCHIVES OF TOXICOLOGY

Levelling the Translational Gap for Animal to Human Efficacy Data

(2020) Guilherme S. Ferreira et al.   Animals

Congruence of Transcription Programs in Adult Stem Cell-Derived Jejunum Organoids and Original Tissue During Long-Term Culture

(2020) Bart van der Hee et al.   Frontiers in Cell and Developmental Biology

Setting the stage for next-generation risk assessment with non-animal approaches: the EU-ToxRisk project experience

(2020) M. J. Moné et al.   ARCHIVES OF TOXICOLOGY

Drosophila melanogaster: A Model Organism to Study Cancer

(2019) Zhasmine Mirzoyan et al.   Frontiers in Genetics

Biomimetic human lung-on-a-chip for modeling disease investigation

(2019) Kaiyan Li et al.   Biomicrofluidics

Analysis of exposure margins in developmental toxicity studies for detection of human teratogens

(2019) Paul A. Andrews et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development

(2019) Jonathon Parrish et al.   TRENDS IN BIOTECHNOLOGY

Exploring current read-across applications and needs among selected U.S. Federal Agencies

(2019) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology – Evolution versus revolution

(2019) T. Burgdorf et al.   TOXICOLOGY IN VITRO

The NIH microphysiological systems program: developing in vitro tools for safety and efficacy in drug development

(2019) Danilo A Tagle   CURRENT OPINION IN PHARMACOLOGY

Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips

(2018) Yusuf B. Arık et al.   Biomicrofluidics

Ecotoxicology Goes on a Chip: Embracing Miniaturized Bioanalysis in Aquatic Risk Assessment

(2018) Olivia Campana et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Adverse outcome pathway networks II: Network analytics

(2018) Daniel L. Villeneuve et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathway networks I: Development and applications

(2018) Dries Knapen et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Microsensor systems for cell metabolism – from 2D culture to organ-on-chip

(2018) Jochen Kieninger et al.   LAB ON A CHIP

Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility

(2018) Thomas Luechtefeld et al.   TOXICOLOGICAL SCIENCES

AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks

(2018) Maureen E. Pittman et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Validation redefined

(2018) Aldert H. Piersma et al.   TOXICOLOGY IN VITRO

Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies

(2018) A.H. Piersma et al.   TOXICOLOGY IN VITRO

In vitro to in vivo extrapolation for high throughput prioritization and decision making

(2018) Shannon M. Bell et al.   TOXICOLOGY IN VITRO

3S - Systematic, systemic, and systems biology and toxicology

(2018) Lena Smirnova   ALTEX-Alternatives to Animal Experimentation

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

(2018) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

(2018) David Pamies   ALTEX-Alternatives to Animal Experimentation

Rethinking developmental toxicity testing: Evolution or revolution?

(2018) Anthony R. Scialli et al.   Birth Defects Research

Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system

(2018) Carlota Oleaga et al.   BIOMATERIALS

Genetic and transcriptional evolution alters cancer cell line drug response

(2018) Uri Ben-David et al.   NATURE

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Organ-on-chip models: Implications in drug discovery and clinical applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology

(2017) Rory B. Conolly et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Modeling Physiological Events in 2D vs. 3D Cell Culture

(2017) Kayla Duval et al.   PHYSIOLOGY

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications

(2017) Alicia Paini et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In vitro to in vivo extrapolation of effective dosimetry in developmental toxicity testing: Application of a generic PBK modelling approach

(2017) Styliani Fragki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

(2017) Matthias S. Roost et al.   Nature Communications

21st Century Cell Culture for 21st Century Toxicology

(2016) David Pamies et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Organoids: Modeling Development and the Stem Cell Niche in a Dish

(2016) Kai Kretzschmar et al.   DEVELOPMENTAL CELL

Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data

(2016) Scott Auerbach et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program

(2016) Agnes L. Karmaus et al.   FOOD AND CHEMICAL TOXICOLOGY

Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

(2016) E. L. Jackson et al.   Integrative Biology

Toward Good Read-Across Practice (GRAP) guidance

(2016) Nicholas Ball   ALTEX-Alternatives to Animal Experimentation

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions

(2015) Tewes Tralau et al.   ARCHIVES OF TOXICOLOGY

The safety, efficacy and regulatory triangle in drug development: Impact for animal models and the use of animals

(2015) Peter J.K. van Meer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation

(2014) Alexander Peyton Nesmith et al.   LAB ON A CHIP

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

(2014) Natalie Alépée   ALTEX-Alternatives to Animal Experimentation

A phenotypic comparison of osteoblast cell lines versus human primary osteoblasts for biomaterials testing

(2013) E. M. Czekanska et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The Clinical Relevance of Cancer Cell Lines

(2013) J.-P. Gillet et al.   JNCI-Journal of the National Cancer Institute

The value of non-human primates in the development of monoclonal antibodies

(2013) P J K van Meer et al.   NATURE BIOTECHNOLOGY

Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro

(2013) Akihito Tanaka et al.   PLoS One

Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

(2011) Hossein Tavana et al.   BIOMEDICAL MICRODEVICES

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells

(2009) Jianhua Zhang et al.   CIRCULATION RESEARCH

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

(2009) H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

Hematopoietic and endothelial differentiation of human induced pluripotent stem cells

(2009) Kyung-Dal Choi et al.   STEM CELLS