Rethinking developmental toxicity testing: Evolution or revolution?

Application of Adverse Outcome Pathways to U.S. EPA’s Endocrine Disruptor Screening Program

(2017) Patience Browne et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Has Toxicity Testing Moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology

(2017) Virginia Zaunbrecher et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Programming microphysiological systems for children’s health protection

(2017) TB Knudsen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Probabilistic assessment method of the non-monotonic dose-responses-Part I: Methodological approach

(2017) Grégoire Chevillotte et al.   FOOD AND CHEMICAL TOXICOLOGY

The Threshold of Toxicological Concern for prenatal developmental toxicity in rats and rabbits

(2017) B. van Ravenzwaay et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Reproductive and developmental toxicology studies with gantenerumab in PS2APP transgenic mice

(2017) Paul Barrow et al.   REPRODUCTIVE TOXICOLOGY

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

(2016) Ann M. Richard et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Point of departure (PoD) selection for the derivation of acceptable daily exposures (ADEs) for active pharmaceutical ingredients (APIs)

(2016) Joel P. Bercu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Computational modeling and simulation of genital tubercle development

(2016) Maxwell C.K. Leung et al.   REPRODUCTIVE TOXICOLOGY

Grouping 34 Chemicals Based on Mode of Action Using Connectivity Mapping

(2016) K. Nadira De Abrew et al.   TOXICOLOGICAL SCIENCES

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

(2016) Clemens Wittwehr et al.   TOXICOLOGICAL SCIENCES

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

(2016) Richard Judson et al.   TOXICOLOGICAL SCIENCES

Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology

(2015) G. T. Knight et al.   CHEMICAL COMMUNICATIONS

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis

(2015) Elisa C.M. Tonk et al.   REPRODUCTIVE TOXICOLOGY

SEURAT: Safety Evaluation Ultimately Replacing Animal Testing—Recommendations for future research in the field of predictive toxicology

(2014) George Daston et al.   ARCHIVES OF TOXICOLOGY

Somites Without a Clock

(2014) A. S. Dias et al.   SCIENCE

Establishment and Assessment of a New Human Embryonic Stem Cell-Based Biomarker Assay for Developmental Toxicity Screening

(2013) Jessica A. Palmer et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Framework for Identifying Chemicals with Structural Features Associated with the Potential to Act as Developmental or Reproductive Toxicants

(2013) Shengde Wu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of a Statistical Model to Predict the Potential for Repeated Dose and Developmental Toxicity of Dermally Administered Crude Oil and Relation to Reproductive Toxicity

(2013) Richard H. McKee et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The threshold of toxicological concern for prenatal developmental toxicity in rabbits and a comparison to TTC values in rats

(2012) B. van Ravenzwaay et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Assessment of diurnal systemic dose of agrochemicals in regulatory toxicity testing – An integrated approach without additional animal use

(2012) Shakil A. Saghir et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Developmental and reproductive toxicology studies in IL-12p40 knockout mice

(2011) Brian P. Enright et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern

(2011) Michael C. Laufersweiler et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

(2011) Nisha S. Sipes et al.   TOXICOLOGICAL SCIENCES

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

(2011) N.C. Kleinstreuer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation

(2011) Susan D. Hester et al.   PLoS Computational Biology

ILSI/HESI maternal toxicity workshop summary: maternal toxicity and its impact on study design and data interpretation

(2010) Bruce K. Beyer et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Predicting developmental toxicity through toxicogenomics

(2010) George P. Daston et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

The threshold of toxicological concern for prenatal developmental toxicity

(2010) B. van Ravenzwaay et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY