Microsensor systems for cell metabolism – from 2D culture to organ-on-chip

Characterization of SH-SY5Y human neuroblastoma cell growth over glass and SU-8 substrates

(2017) A. Ajetunmobi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfabricated, amperometric, enzyme-based biosensors for in vivo applications

(2016) Andreas Weltin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Metabolic response of lung cancer cells to radiation in a paper-based 3D cell culture system

(2016) Karen A. Simon et al.   BIOMATERIALS

A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices

(2016) Seyed Ali Mousavi Shaegh et al.   Biomicrofluidics

Characterization and application of a new pH sensor based on magnetron sputtered porous WO 3 thin films deposited at oblique angles

(2016) Pedro Salazar et al.   ELECTROCHIMICA ACTA

Data Processing in Cellular Microphysiometry

(2016) Joachim Wiest et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

pH response behaviors and mechanisms of different tungsten/tungsten oxide electrodes for long-term monitoring

(2016) Qi Guo et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Surface-tension driven open microfluidic platform for hanging droplet culture

(2016) T. E. de Groot et al.   LAB ON A CHIP

3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates

(2016) E. J. Vrij et al.   LAB ON A CHIP

Implementing oxygen control in chip-based cell and tissue culture systems

(2016) Pieter E. Oomen et al.   LAB ON A CHIP

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated multi-sensor system for parallel in-situ monitoring of cell nutrients, metabolites, cell density and pH in biotechnological processes

(2016) Stefan Mross et al.   SENSORS AND ACTUATORS B-CHEMICAL

Electrical Impedance Spectroscopy for Microtissue Spheroid Analysis in Hanging-Drop Networks

(2016) Yannick R. F. Schmid et al.   ACS Sensors

Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks

(2016) Patrick M. Misun et al.   Microsystems & Nanoengineering

Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers

(2016) Reza Riahi et al.   Scientific Reports

Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

(2015) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Real-Time Monitoring of Cellular Bioenergetics with a Multianalyte Screen-Printed Electrode

(2015) Jennifer R. McKenzie et al.   ANALYTICAL CHEMISTRY

Superoxide microsensor integrated into a Sensing Cell Culture Flask microsystem using direct oxidation for cell culture application

(2015) H. Flamm et al.   BIOSENSORS & BIOELECTRONICS

Towards personalized medicine: chemosensitivity assays of patient lung cancer cell spheroids in a perfused microfluidic platform

(2015) Janine Ruppen et al.   LAB ON A CHIP

Multiscattering-enhanced optical biosensor: multiplexed, non-invasive and continuous measurements of cellular processes

(2015) Volodymyr B. Koman et al.   Biomedical Optics Express

Long-term microfluidic glucose and lactate monitoring in hepatic cell culture

(2014) Sebastian Prill et al.   Biomicrofluidics

Design, development, and validation of an in-situ biosensor array for metabolite monitoring of cell cultures

(2014) Cristina Boero et al.   BIOSENSORS & BIOELECTRONICS

Polymer-based, flexible glutamate and lactate microsensors for in vivo applications

(2014) Andreas Weltin et al.   BIOSENSORS & BIOELECTRONICS

Pericellular oxygen monitoring with integrated sensor chips for reproducible cell culture experiments

(2014) J. Kieninger et al.   CELL PROLIFERATION

Measuring dissolved oxygen to track erythroid differentiation of hematopoietic progenitor cells in culture

(2014) Susan M. Browne et al.   JOURNAL OF BIOTECHNOLOGY

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

(2014) Erik O. Pettersen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A method for estimating the oxygen consumption rate in multicellular tumour spheroids

(2014) D. R. Grimes et al.   Journal of the Royal Society Interface

A microfluidic-based platform for tumour spheroid culture, monitoring and drug screening

(2014) K. Kwapiszewska et al.   LAB ON A CHIP

Oxygen control with microfluidics

(2014) Martin D. Brennan et al.   LAB ON A CHIP

Microvasculature: An essential component for organ-on-chip systems

(2014) Hyunjae Lee et al.   MRS BULLETIN

Fabrication and Evaluation of a Micro(Bio)Sensor Array Chip for Multiple Parallel Measurements of Important Cell Biomarkers

(2014) Roy Pemberton et al.   SENSORS

Integrated multifunctional cell-based biosensor system for monitoring extracellular acidification and cellular growth

(2014) Kaiqi Su et al.   SENSORS AND ACTUATORS A-PHYSICAL

The effects of sensing electrode thickness on ruthenium oxide thin-film pH sensor

(2014) A. Sardarinejad et al.   SENSORS AND ACTUATORS A-PHYSICAL

Fabrication method and characterization of electrodeposited and heat-treated iridium oxide films for pH sensing

(2014) Tae Yong Kim et al.   SENSORS AND ACTUATORS B-CHEMICAL

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Platform for High-Throughput Testing of the Effect of Soluble Compounds on 3D Cell Cultures

(2013) Frédérique Deiss et al.   ANALYTICAL CHEMISTRY

Automated platform for sensor-based monitoring and controlled assays of living cells and tissues

(2013) P. Wolf et al.   BIOSENSORS & BIOELECTRONICS

Human-on-chip for therapy development and fundamental science

(2013) Camilla Luni et al.   CURRENT OPINION IN BIOTECHNOLOGY

Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem

(2013) Andreas Weltin et al.   LAB ON A CHIP

Oxygen levels in thermoplastic microfluidic devices during cell culture

(2013) Christopher J. Ochs et al.   LAB ON A CHIP

In vitro and in vivo evaluation of SU-8 biocompatibility

(2013) Krishnamurthy V. Nemani et al.   Materials Science & Engineering C-Materials for Biological Applications

Cellular impedance sensing combined with LAPS as a new means for real-time monitoring cell growth and metabolism

(2013) Chengxiong Wu et al.   SENSORS AND ACTUATORS A-PHYSICAL

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

Metabolic Multianalyte Microphysiometry Reveals Extracellular Acidosis is an Essential Mediator of Neuronal Preconditioning

(2012) Jennifer R. McKenzie et al.   ACS Chemical Neuroscience

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

A novel microphysiometer based on high sensitivity LAPS and microfluidic system for cellular metabolism study and rapid drug screening

(2012) Ning Hu et al.   BIOSENSORS & BIOELECTRONICS

Connecting the Chemical and Biological Properties of Nitric Oxide

(2012) Jose Carlos Toledo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

On-chip anticancer drug test of regular tumor spheroids formed in microwells by a distributive microchannel network

(2012) Choong Kim et al.   LAB ON A CHIP

Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy

(2012) Alon Greenbaum et al.   NATURE METHODS

A Self-Contained System With CNTs-Based Biosensors for Cell Culture Monitoring

(2012) Cristina Boero et al.   IEEE Journal on Emerging and Selected Topics in Circuits and Systems

Highly Sensitive Carbon Nanotube-Based Sensing for Lactate and Glucose Monitoring in Cell Culture

(2011) C Boero et al.   IEEE TRANSACTIONS ON NANOBIOSCIENCE

Real-Time Monitoring of Cisplatin-Induced Cell Death

(2011) Hamed Alborzinia et al.   PLoS One

The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM)

(2011) G. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptation to oxygen deprivation in cultures of human pluripotent stem cells, endothelial progenitor cells, and umbilical vein endothelial cells

(2010) Hasan Erbil Abaci et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Enzyme-coated microelectrodes to monitor lactate production in a nanoliter microfluidic cell culture device

(2010) Igor A. Ges et al.   BIOSENSORS & BIOELECTRONICS

A screen-printed microband glucose biosensor system for real-time monitoring of toxicity in cell culture

(2010) R.M. Pemberton et al.   BIOSENSORS & BIOELECTRONICS

High glucose concentrations attenuate hypoxia-inducible factor-1α expression and signaling in non-tumor cells

(2010) Nathalie Dehne et al.   EXPERIMENTAL CELL RESEARCH

Dually fluorescent sensing of pH and dissolved oxygen using a membrane made from polymerizable sensing monomers

(2010) Yanqing Tian et al.   SENSORS AND ACTUATORS B-CHEMICAL

Different stages of pluripotency determine distinct patterns of proliferation, metabolism, and lineage commitment of embryonic stem cells under hypoxia

(2010) Tiago G. Fernandes et al.   Stem Cell Research

Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals

(2009) Gerardo Ferrer-Sueta et al.   ACS Chemical Biology

A Noninvasive Thin Film Sensor for Monitoring Oxygen Tension during in Vitro Cell Culture

(2009) Peter C. Thomas et al.   ANALYTICAL CHEMISTRY

Enzyme electrodes to monitor glucose consumption of single cardiac myocytes in sub-nanoliter volumes

(2009) Igor A. Ges et al.   BIOSENSORS & BIOELECTRONICS

Chemoradiation interactions under reduced oxygen conditions: Cellular characteristics of an in vitro model

(2009) An Wouters et al.   CANCER LETTERS

The Bionas technology for anticancer drug screening

(2009) Pedro Mestres et al.   Expert Opinion on Drug Discovery

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

(2009) Peter Ebbesen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

A Clark-type oxygen chip for in situ estimation of the respiratory activity of adhering cells

(2009) Ching-Chou Wu et al.   TALANTA

High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements

(2009) Simone Beckers et al.   TOXICOLOGY IN VITRO

Application of screen-printed microband biosensors to end-point measurements of glucose and cell numbers in HepG2 cell culture

(2008) R.M. Pemberton et al.   ANALYTICAL BIOCHEMISTRY

Detection of the Superoxide Radical Anion Using Various Alkanethiol Monolayers and Immobilized Cytochromec

(2008) Xiaojun J. Chen et al.   ANALYTICAL CHEMISTRY

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Electrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress

(2008) Christian Amatore et al.   CHEMICAL REVIEWS

Monitoring pH and dissolved oxygen in mammalian cell culture using optical sensors

(2008) Mariam Naciri et al.   CYTOTECHNOLOGY

Ultra wide-field lens-free monitoring of cells on-chip

(2007) Aydogan Ozcan et al.   LAB ON A CHIP

Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing

(2007) Min-Hsien Wu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Measurement of pH and dissolved oxygen within cell culture media using a hydrogel microarray sensor

(2007) Seungjoon Lee et al.   SENSORS AND ACTUATORS B-CHEMICAL

Preparation and characteristics of ruthenium dioxide for pH array sensors with real-time measurement system

(2007) Yi-Hung Liao et al.   SENSORS AND ACTUATORS B-CHEMICAL