Biomimetic human lung-on-a-chip for modeling disease investigation

Probing tumor microtissue formation and epithelial-mesenchymal transition on a well-mesh microchip

(2019) Kaiyan Li et al.   Biomicrofluidics

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

(2018) Xingyuan Yang et al.   LAB ON A CHIP

Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions

(2018) Mouhita Humayun et al.   LAB ON A CHIP

Fibrotic microtissue array to predict anti-fibrosis drug efficacy

(2018) Mohammadnabi Asmani et al.   Nature Communications

Induced pluripotent stem cells for treating cystic fibrosis: State of the science

(2018) Bette S. Pollard et al.   PEDIATRIC PULMONOLOGY

Multi-organ on a chip for personalized precision medicine

(2018) Vivekanandan Palaninathan et al.   MRS Communications

A 3D human lung-on-a-chip model for nanotoxicity testing

(2018) Min Zhang et al.   Toxicology Research

Application of chemical reaction engineering principles to “body-on-a-chip” systems

(2018) Jong Hwan Sung et al.   AICHE JOURNAL

Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases

(2017) Tinne C.J. Mertens et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Challenge in particle delivery to cells in a microfluidic device

(2017) Hajar Moghadas et al.   Drug Delivery and Translational Research

Advances in pulmonary therapy and drug development: Lung tissue engineering to lung-on-a-chip

(2016) Ali Doryab et al.   BIOTECHNOLOGY ADVANCES

Regulation of prostate cancer progression by the tumor microenvironment

(2016) Stephen L. Shiao et al.   CANCER LETTERS

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device

(2016) Ting Yu et al.   Oncotarget

Advances and Challenges in Recapitulating Human Pulmonary Systems: At the Cusp of Biology and Materials

(2016) Piyush Bajaj et al.   ACS Biomaterials-Science & Engineering

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

Advances and Challenges in Recapitulating Human Pulmonary Systems: At the Cusp of Biology and Materials

(2016) Piyush Bajaj et al.   ACS Biomaterials Science & Engineering

Engineering cell microenvironment using novel functional hydrogels

(2015) Xiaohui Zhang et al.   EUROPEAN POLYMER JOURNAL

A biologically inspired lung-on-a-chip device for the study of protein-induced lung inflammation

(2015) Tushar H. Punde et al.   Integrative Biology

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

(2015) JiSoo Park et al.   LAB ON A CHIP

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

(2015) Jeremy D. Caplin et al.   Advanced Healthcare Materials

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

Engineering living systems on chips: from cells to human on chips

(2014) Yoshitaka Sei et al.   Microfluidics and Nanofluidics

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Influence of the microenvironment on cell fate determination and migration

(2014) Alexander B. Bloom et al.   PHYSIOLOGICAL GENOMICS

The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment

(2014) Jun Ye et al.   TUMOR BIOLOGY

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

Human-on-chip for therapy development and fundamental science

(2013) Camilla Luni et al.   CURRENT OPINION IN BIOTECHNOLOGY

The future of the patient-specific Body-on-a-chip

(2013) Adam Williamson et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Biomechanical Forces Shape the Tumor Microenvironment

(2011) Adrian C. Shieh   ANNALS OF BIOMEDICAL ENGINEERING

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

(2011) Hossein Tavana et al.   BIOMEDICAL MICRODEVICES

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Biomimetic three-dimensional microenvironment for controlling stem cell fate

(2011) H. Zhang et al.   Interface Focus

A microfluidic respiratory assist device with high gas permeance for artificial lung applications

(2010) Tatiana Kniazeva et al.   BIOMEDICAL MICRODEVICES

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

The tumor microenvironment and its contribution to tumor evolution toward metastasis

(2008) Girieca Lorusso et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Droplet microfluidics

(2008) Shia-Yen Teh et al.   LAB ON A CHIP

Melanoma and the tumor microenvironment

(2008) Jessie Villanueva et al.   Current Oncology Reports