Quantitative adverse outcome pathway (qAOP) models for toxicity prediction

Developing adverse outcome pathways on silver nanoparticle-induced reproductive toxicity via oxidative stress in the nematode Caenorhabditis elegans using a Bayesian network model

(2019) Jaeseong Jeong et al.   Nanotoxicology

When are Adverse Outcome Pathways and Associated Assays “Fit for Purpose” for Regulatory Decision‐Making and Management of Chemicals?

(2019) Katie Coady et al.   Integrated Environmental Assessment and Management

Extracting and Benchmarking Emerging Adverse Outcome Pathway Knowledge

(2019) Nathan L Pollesch et al.   TOXICOLOGICAL SCIENCES

Development of Adverse Outcome Pathway for PPARγ antagonism leading to pulmonary fibrosis and chemical selection for its validation: ToxCast™ database and a deep learning artificial neural network model based approach

(2019) Jaeseong Jeong et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Toxicokinetic and toxicodynamic (TK-TD) modeling to study oxidative stress-dependent toxicity of heavy metals in zebrafish

(2019) Yongfei Gao et al.   CHEMOSPHERE

Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach

(2019) Jean-Charles Carvaillo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Linking mitochondrial dysfunction to organismal and population health in context of environmental pollutants: Progress and considerations for mitochondrial adverse outcome pathways

(2019) David A. Dreier et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse Outcome Pathways: Moving from a Scientific Concept to an Internationally Accepted Framework

(2019) Markus Hecker et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment

(2019) Edward J. Perkins et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Application of Bayesian networks in determining nanoparticle-induced cellular outcomes using transcriptomics

(2019) Irini Furxhi et al.   Nanotoxicology

sAOP: linking chemical stressors to adverse outcomes pathway networks

(2019) Alejandro Aguayo-Orozco et al.   BIOINFORMATICS

An industry perspective: A streamlined screening strategy using alternative models for chemical assessment of developmental neurotoxicity

(2019) Jinpeng Li et al.   NEUROTOXICOLOGY

Development and analysis of an adverse outcome pathway network for human neurotoxicity

(2019) Nicoleta Spinu et al.   ARCHIVES OF TOXICOLOGY

Quantitative Predictions for Molecular Initiating Events using 3D Quantitative Structure-Activity Relationships

(2019) Timothy Eric Harry Allen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Adverse outcome pathways potentially related to hazard identification of microplastics based on toxicity mechanisms

(2019) Jaeseong Jeong et al.   CHEMOSPHERE

Quantitative Response-Response Relationships Linking Aromatase Inhibition to Decreased Fecundity are Conserved Across Three Fishes with Asynchronous Oocyte Development

(2019) Jon A. Doering et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Predicting Drug-Induced Liver Injury with Bayesian Machine Learning

(2019) Dominic P. Williams et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting the Probability that a Chemical Causes Steatosis Using Adverse Outcome Pathway Bayesian Networks (AOPBNs)

(2019) Lyle D. Burgoon et al.   RISK ANALYSIS

Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches

(2019) Marylène Rugard et al.   TOXICOLOGICAL SCIENCES

A Cross-species Quantitative Adverse Outcome Pathway for Activation of the Aryl Hydrocarbon Receptor Leading to Early Life Stage Mortality in Birds and Fishes

(2018) Jon A. Doering et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Adverse outcome pathway networks II: Network analytics

(2018) Daniel L. Villeneuve et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathway networks I: Development and applications

(2018) Dries Knapen et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Harvesting the promise of AOPs: An assessment and recommendations

(2018) Annamaria Carusi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks

(2018) Maureen E. Pittman et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Is there a role for the adverse outcome pathway framework to support radiation protection?

(2018) Vinita Chauhan et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology

(2017) Rory B. Conolly et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Advancing the adverse outcome pathway framework-An international horizon scanning approach

(2017) Carlie A. LaLone et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Quantitative weight of evidence to assess confidence in potential modes of action

(2017) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework

(2017) Iman Hassan et al.   TOXICOLOGICAL SCIENCES

Editor’s Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis

(2017) Michelle M. Angrish et al.   TOXICOLOGICAL SCIENCES

A Bayesian network model for predicting aquatic toxicity mode of action using two dimensional theoretical molecular descriptors

(2016) John F. Carriger et al.   AQUATIC TOXICOLOGY

Using Molecular Initiating Events to Develop a Structural Alert Based Screening Workflow for Nuclear Receptor Ligands Associated with Hepatic Steatosis

(2016) Claire L. Mellor et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A History of the Molecular Initiating Event

(2016) Timothy E. H. Allen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Adverse outcome pathways: From research to regulation scientific workshop report

(2016) Nicole C. Kleinstreuer et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A weight of evidence assessment approach for adverse outcome pathways

(2016) Zachary A. Collier et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

(2016) Clemens Wittwehr et al.   TOXICOLOGICAL SCIENCES

Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish

(2016) Luigi Margiotta-Casaluci et al.   Scientific Reports

Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy

(2015) Joanna S. Jaworska et al.   ARCHIVES OF TOXICOLOGY

Quantitative Adverse Outcome Pathway Analysis of Hatching in Zebrafish with CuO Nanoparticles

(2015) Erik B. Muller et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

(2015) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence

(2015) Edward J. Perkins et al.   TOXICOLOGICAL SCIENCES

Limitations of toxicity characterization in life cycle assessment: Can adverse outcome pathways provide a new foundation?

(2015) Kurt A Gust et al.   Integrated Environmental Assessment and Management

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment

(2014) Cameron MacKay   ALTEX-Alternatives to Animal Experimentation

Adverse outcome pathways during zebrafish embryogenesis: A case study with paraoxon

(2012) Krystle L. Yozzo et al.   AQUATIC TOXICOLOGY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

A Bayesian Network Model for Biomarker-Based Dose Response

(2010) C. Eric Hack et al.   RISK ANALYSIS