Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions

Non-animal methodologies within biomedical research and toxicity testing

(2016) Andrew Knight   ALTEX-Alternatives to Animal Experimentation

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)

(2016) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

Long term cultures of primary human hepatocytes as an alternative to drug testing in animals

(2016) Anett Ullrich   ALTEX-Alternatives to Animal Experimentation

Insights on the human microbiome and its xenobiotic metabolism: what is known about its effects on human physiology?

(2014) Tewes Tralau et al.   Expert Opinion on Drug Metabolism & Toxicology

No Animals Harmed:Toward a Paradigm Shift in Toxicity Testing

(2014) Joanne Zurlo   HASTINGS CENTER REPORT

On mapping the human toxome

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Uncertainty of testing methods – What do we (want to) know?

(2014) Martin Paparella   ALTEX-Alternatives to Animal Experimentation

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

(2014) Richard Judson   ALTEX-Alternatives to Animal Experimentation

Unraveling the Health Effects of Environmental Mixtures: An NIEHS Priority

(2013) Danielle J. Carlin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Regulatory agency struggles under the weight of genomic data

(2013) Yevgeniy Grigoryev   NATURE MEDICINE

Use of nutrigenomics endpoints in dietary interventions

(2013) Henk F. J. Hendriks   PROCEEDINGS OF THE NUTRITION SOCIETY

Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure

(2012) Yuri Dancik et al.   ADVANCED DRUG DELIVERY REVIEWS

Detailed modeling of skin penetration—An overview

(2012) Arne Naegel et al.   ADVANCED DRUG DELIVERY REVIEWS

Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes

(2012) Yuri G. Anissimov et al.   ADVANCED DRUG DELIVERY REVIEWS

Stress response pathways, toxicity pathways and adverse outcome pathways

(2012) Paul Jennings   ARCHIVES OF TOXICOLOGY

Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies

(2012) Stefan A. Hoffmann et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell-based therapies for lung disease

(2012) O. Garcia et al.   BRITISH MEDICAL BULLETIN

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Wind of Change Challenges Toxicological Regulators

(2012) Tewes Tralau et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Prioritizing Chemicals and Data Requirements for Screening-Level Exposure and Risk Assessment

(2012) Jon A. Arnot et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

“Drugs on oxygen”: an update and perspective on the role of cytochrome P450 testing in pharmacology

(2012) Tewes Tralau et al.   Expert Opinion on Drug Metabolism & Toxicology

An illusion of hormesis in the Ames test: Statistical significance is not equivalent to biological significance

(2012) Errol Zeiger et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

(2012) Anna Astashkina et al.   PHARMACOLOGY & THERAPEUTICS

Applicability of in vitro tests for skin irritation and corrosion to regulatory classification schemes: Substantiating test strategies with data from routine studies

(2012) Susanne N. Kolle et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Workshop: Use of “read-across” for chemical safety assessment under REACH

(2012) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Identification and Characterization of Adverse Effects in 21st Century Toxicology

(2012) Douglas A. Keller et al.   TOXICOLOGICAL SCIENCES

Science and Decisions: Advancing Toxicology to Advance Risk Assessment

(2012) Joseph V. Rodricks et al.   TOXICOLOGICAL SCIENCES

Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model

(2012) Eric F. Lock et al.   TOXICOLOGICAL SCIENCES

Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure

(2012) Julie A. Bourdon et al.   TOXICOLOGY

Implementation challenges for designing Integrated In Vitro Testing Strategies (ITS) aiming at reducing and replacing animal experimentation

(2012) Bart De Wever et al.   TOXICOLOGY IN VITRO

Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studies

(2012) Martin Wiesinger et al.   TOXICOLOGY IN VITRO

Commentary: Dermal penetration of bisphenol A—Consequences for risk assessment

(2012) Ursula Gundert-Remy et al.   TOXICOLOGY LETTERS

Drug-mediated toxicity: illuminating the ‘bad’ in the test tube by means of cellular assays?

(2012) Tewes Tralau et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The virtual liver: a multidisciplinary, multilevel challenge for systems biology

(2012) Hermann-Georg Holzhütter et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Developmental toxicity testing in the 21st century: the sword of Damocles shattered by embryonic stem cell assays?

(2011) Andrea Seiler et al.   ARCHIVES OF TOXICOLOGY

Present state and future perspectives of using pluripotent stem cells in toxicology research

(2011) Anna M. Wobus et al.   ARCHIVES OF TOXICOLOGY

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

Alternatives to animal testing: current status and future perspectives

(2011) Manfred Liebsch et al.   ARCHIVES OF TOXICOLOGY

A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

(2011) Henrik Johansson et al.   BMC GENOMICS

Network News: Innovations in 21st Century Systems Biology

(2011) Adam P. Arkin et al.   CELL

Evolution of Gene Regulatory Networks Controlling Body Plan Development

(2011) Isabelle S. Peter et al.   CELL

Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects

(2011) M. Peiser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mathematical models of skin permeability: An overview

(2011) Samir Mitragotri et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

GRADE guidelines: 3. Rating the quality of evidence

(2011) Howard Balshem et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

A living system on a chip

(2011) Monya Baker   NATURE

A decision-directed approach for prioritizing research into the impact of nanomaterials on the environment and human health

(2011) Igor Linkov et al.   Nature Nanotechnology

Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity

(2011) Reha Yildirimman et al.   TOXICOLOGICAL SCIENCES

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals

(2011) Caroline Bauch et al.   TOXICOLOGY IN VITRO

Physiologically based toxicokinetic modelling as a tool to assess target organ toxicity in route-to-route extrapolation—The case of coumarin

(2011) Hans Mielke et al.   TOXICOLOGY LETTERS

Organ engineering based on decellularized matrix scaffolds

(2011) Jeremy J. Song et al.   TRENDS IN MOLECULAR MEDICINE

Innovation in safety pharmacology testing

(2011) M.K. Pugsley et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing

(2010) Hans Mielke et al.   ARCHIVES OF TOXICOLOGY

High-content screening of small compounds on human embryonic stem cells

(2010) Ivana Barbaric et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pluripotent Human Stem Cells

(2010) Blaine W. Phillips et al.   BIODRUGS

Sicherheitsbewertung von Materialien im Kontakt mit Lebensmitteln

(2010) D. Wölfle et al.   Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz

In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs

(2010) M.J. Gomez-Lechon et al.   CURRENT PHARMACEUTICAL DESIGN

Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity

(2010) Richard S. Judson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Human ES cell lines—introduction

(2010) Peter W. Andrews et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Vascularised human tissue models: A new approach for the refinement of biomedical research

(2010) Johanna Schanz et al.   JOURNAL OF BIOTECHNOLOGY

Exploring In Vitro/In Vivo Correlation: Lessons Learned from Analyzing Phase I Results of the US EPA's ToxCast Project

(2010) ROMUALDO BENIGNI et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Computational Toxicology as Implemented by the U.S. EPA: Providing High Throughput Decision Support Tools for Screening and Assessing Chemical Exposure, Hazard and Risk

(2010) Robert Kavlock et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Distributed biological computation with multicellular engineered networks

(2010) Sergi Regot et al.   NATURE

Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix

(2010) Basak E Uygun et al.   NATURE MEDICINE

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

(2010) S. Hoehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants

(2010) Barbara Schenk et al.   REPRODUCTIVE TOXICOLOGY

A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals

(2010) Alan F Sasso et al.   Theoretical Biology and Medical Modelling

Stem Cells in Toxicology: Fundamental Biology and Practical Considerations

(2010) K.-S. Kang et al.   TOXICOLOGICAL SCIENCES

Identifying and characterizing chemical skin sensitizers without animal testing: Colipa’s research and method development program

(2010) P. Aeby et al.   TOXICOLOGY IN VITRO

Multiscale Modeling Framework of Transdermal Drug Delivery

(2009) Jee E. Rim et al.   ANNALS OF BIOMEDICAL ENGINEERING

EU research activities in alternative testing strategies: current status and future perspectives

(2009) T. Vanhaecke et al.   ARCHIVES OF TOXICOLOGY

The Potential of Embryonic Stem Cells Combined with -omics Technologies as Model Systems for Toxicology

(2009) J. Winkler et al.   CURRENT MEDICINAL CHEMISTRY

The future of drug safety testing: expanding the view and narrowing the focus

(2009) James L. Stevens et al.   DRUG DISCOVERY TODAY

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A catalogue of reporting guidelines for health research

(2009) I. Simera et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

3.3 Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity – molecular mechanisms and lessons for pharmacotoxicity

(2009) J Borlak   HUMAN & EXPERIMENTAL TOXICOLOGY

Twenty-first century approaches to toxicity testing, biomonitoring and risk assessment: perspectives from the global chemical industry

(2009) Richard D Phillips et al.   Journal of Exposure Science and Environmental Epidemiology

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Reactivity Profiling: Covalent Modification of Single Nucleophile Peptides for Skin Sensitization Risk Assessment

(2009) Maja Aleksic et al.   TOXICOLOGICAL SCIENCES

Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment

(2009) James Edward Trosko et al.   TOXICOLOGY

“ToxRTool”, a new tool to assess the reliability of toxicological data

(2009) Klaus Schneider et al.   TOXICOLOGY LETTERS

Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH)

(2008) W. Lilienblum et al.   ARCHIVES OF TOXICOLOGY

Bioinformatics, multiscale modeling and the IUPS Physiome Project

(2008) P. J. Hunter et al.   BRIEFINGS IN BIOINFORMATICS

The State of Innovation in Drug Development

(2008) I Kola   CLINICAL PHARMACOLOGY & THERAPEUTICS

Use of “Bricks and Mortar” Model To Predict Transdermal Permeation: Model Development and Initial Validation

(2008) Longjian Chen et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Reconstructing population exposures to environmental chemicals from biomarkers: Challenges and opportunities

(2008) Panos G Georgopoulos et al.   Journal of Exposure Science and Environmental Epidemiology

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

In-silico model of skin penetration based on experimentally determined input parameters. Part II: Mathematical modelling of in-vitro diffusion experiments. Identification of critical input parameters

(2007) Arne Naegel et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

(2007) Heidrun Ellinger-Ziegelbauer et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Exposure-triggered reproductive toxicity testing under the REACH legislation: A proposal to define significant/relevant exposure

(2007) Ulrike Bernauer et al.   TOXICOLOGY LETTERS