Cholesterol metabolism: a new molecular switch to control inflammation
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Title
Cholesterol metabolism: a new molecular switch to control inflammation
Authors
Keywords
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Journal
CLINICAL SCIENCE
Volume 135, Issue 11, Pages 1389-1408
Publisher
Portland Press Ltd.
Online
2021-06-04
DOI
10.1042/cs20201394
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Note: Only part of the references are listed.- Geranylgeranyl pyrophosphate amplifies T reg differentiation via increased IL‐2 expression to ameliorate DSS‐induced colitis
- (2021) Mahesh Pandit et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Atorvastatin inhibits IL-17A, TNF, IL-6, and IL-10 in PBMC cultures from patients with severe rheumatoid arthritis
- (2020) Priscilla Stela Santana de Oliveira et al. IMMUNOBIOLOGY
- LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes
- (2020) Yahya Sohrabi et al. Frontiers in Immunology
- Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine
- (2020) Michael N. Trinh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities
- (2020) Jin Zhao et al. Viruses-Basel
- Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
- (2020) Jack A. Bibby et al. Nature Communications
- Impact of Cholesterol Metabolism in Immune Cell Function and Atherosclerosis
- (2020) María Aguilar-Ballester et al. Nutrients
- Cholesterol-25-hydroxylase promotes efferocytosis and resolution of lung inflammation
- (2020) Jennifer H. Madenspacher et al. JCI Insight
- Does adherence to lipid‐lowering medications improve cancer survival? A nationwide study of breast and colorectal cancer, and melanoma
- (2020) Jia‐Li Feng et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Diverse Immunoregulatory Roles of Oxysterols—The Oxidized Cholesterol Metabolites
- (2020) Chloe Choi et al. Metabolites
- Cholesterol metabolism: At the cross road between cancer cells and immune environment
- (2020) Joanna Kopecka et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
- (2019) Esperanza Perucha et al. Nature Communications
- The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis
- (2019) Annika Wyss et al. Mucosal Immunology
- Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression
- (2019) Pieter Goossens et al. Cell Metabolism
- Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
- (2019) Swechha M. Pokharel et al. Nature Communications
- The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
- (2019) Anthony Kusnadi et al. IMMUNITY
- Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
- (2019) Maheshwor Timilshina et al. Cell Reports
- Biology and therapeutic potential of interleukin-10
- (2019) Margarida Saraiva et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
- (2019) Murali K. Akula et al. Nature Communications
- Lipoprotein receptor signalling in atherosclerosis
- (2019) Chieko Mineo CARDIOVASCULAR RESEARCH
- Mechanisms and regulation of cholesterol homeostasis
- (2019) Jie Luo et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Foam Cells: One Size Doesn’t Fit All
- (2019) Valentina Guerrini et al. TRENDS IN IMMUNOLOGY
- The anti-inflammatory effects of statins on patients with rheumatoid arthritis: A systemic review and meta-analysis of 15 randomized controlled trials
- (2018) Guo-min Li et al. AUTOIMMUNITY REVIEWS
- Metabolic Induction of Trained Immunity through the Mevalonate Pathway
- (2018) Siroon Bekkering et al. CELL
- Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease
- (2018) Angela Jeong et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Hypercholesterolemia induces T cell expansion in humanized immune mice
- (2018) Jonathan D. Proto et al. JOURNAL OF CLINICAL INVESTIGATION
- Cholesterol negatively regulates IL-9–producing CD8+T cell differentiation and antitumor activity
- (2018) Xingzhe Ma et al. JOURNAL OF EXPERIMENTAL MEDICINE
- 25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism
- (2018) Ying Liu et al. JOURNAL OF LIPID RESEARCH
- Liver X receptors in lipid signalling and membrane homeostasis
- (2018) Bo Wang et al. Nature Reviews Endocrinology
- Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes
- (2018) Fabrizio De Benedetti et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery
- (2018) Yun Xia et al. CELL
- Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
- (2018) Marianne de la Roche et al. JOURNAL OF CELL BIOLOGY
- 25-Hydroxycholesterol protects against acute lung injury via targeting MD-2
- (2018) Wei Ouyang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation
- (2018) Mingming Sun et al. JOURNAL OF IMMUNOLOGY
- IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
- (2018) Minkyung Song et al. NATURE
- LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux
- (2018) David G. Thomas et al. Cell Reports
- Foundations of Immunometabolism and Implications for Metabolic Health and Disease
- (2017) Gökhan S. Hotamisligil IMMUNITY
- Immune oxysterols: Role in mycobacterial infection and inflammation
- (2017) Saikou Y. Bah et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Liver X receptor activation promotes differentiation of regulatory T cells
- (2017) Martin Herold et al. PLoS One
- Inflammation and metabolism in tissue repair and regeneration
- (2017) Sabine A. Eming et al. SCIENCE
- Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages
- (2017) Elisa Araldi et al. Cell Reports
- Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice
- (2017) Britta Noebauer et al. Journal of Diabetes Research
- IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production
- (2017) Solenne Vigne et al. Frontiers in Immunology
- Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation
- (2016) Deepika Awasthi et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cholesterol Accumulation in CD11c + Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease
- (2016) Ayaka Ito et al. IMMUNITY
- Lipid rafts in immune signalling: current progress and future perspective
- (2016) Pallavi Varshney et al. IMMUNOLOGY
- MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains
- (2016) Lihua Lai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation
- (2016) Monica Molteni et al. MEDIATORS OF INFLAMMATION
- Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
- (2016) Wei Yang et al. NATURE
- Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol
- (2016) Feng Wang et al. NATURE IMMUNOLOGY
- Control of the innate immune response by the mevalonate pathway
- (2016) Murali K Akula et al. NATURE IMMUNOLOGY
- Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
- (2016) Yong Hwan Park et al. NATURE IMMUNOLOGY
- Resolution of inflammation: a new therapeutic frontier
- (2016) James N. Fullerton et al. NATURE REVIEWS DRUG DISCOVERY
- The Intracellular Cholesterol Landscape: Dynamic Integrator of the Immune Response
- (2016) Michael B. Fessler TRENDS IN IMMUNOLOGY
- 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
- (2016) Jiho Jang et al. Nature Communications
- The Phenotype and Genotype of Mevalonate Kinase Deficiency: A Series of 114 Cases From the Eurofever Registry
- (2016) Nienke M. ter Haar et al. Arthritis & Rheumatology
- The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer
- (2016) Amy E. Baek et al. Hormones & Cancer
- Interferon Control of the Sterol Metabolic Network: Bidirectional Molecular Circuitry-Mediating Host Protection
- (2016) Kevin A. Robertson et al. Frontiers in Immunology
- Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling
- (2015) Autumn G. York et al. CELL
- Homeostasis, Inflammation, and Disease Susceptibility
- (2015) Maya E. Kotas et al. CELL
- Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells
- (2015) Fabio R. Santori et al. Cell Metabolism
- Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism
- (2015) Michael B. Fessler CURRENT ALLERGY AND ASTHMA REPORTS
- Oxysterols regulate encephalitogenic CD4+ T cell trafficking during central nervous system autoimmunity
- (2015) F. Chalmin et al. JOURNAL OF AUTOIMMUNITY
- T cell metabolism drives immunity
- (2015) Michael D. Buck et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Regulation of atherosclerotic plaque inflammation
- (2015) M. Bäck et al. JOURNAL OF INTERNAL MEDICINE
- Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection
- (2015) Yu Xiang et al. JOURNAL OF VIROLOGY
- Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists
- (2015) Xiao Hu et al. Nature Chemical Biology
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
- (2015) A. Warnatsch et al. SCIENCE
- T lymphocyte regulation by mevalonate metabolism
- (2015) Martin Thurnher et al. Science Signaling
- Detection of dihydroxycholesterols in human plasma using HPLC–ESI-MS/MS
- (2015) Ratna Karuna et al. STEROIDS
- Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy
- (2015) Teemu P. Miettinen et al. Cell Reports
- LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling
- (2015) Ayaka Ito et al. eLife
- T lymphocyte regulation by mevalonate metabolism
- (2015) Martin Thurnher et al. Science Signaling
- Protein Prenylation: Enzymes, Therapeutics, and Biotechnology Applications
- (2014) Charuta C. Palsuledesai et al. ACS Chemical Biology
- Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps
- (2014) Ariane Neumann et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- mTOR signaling, Tregs and immune modulation
- (2014) Nicole M Chapman et al. Immunotherapy
- Molecular Mechanisms of Cellular Cholesterol Efflux
- (2014) Michael C. Phillips JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of Protein Geranylgeranylation Specifically Interferes with CD40-Dependent B Cell Activation, Resulting in a Reduced Capacity To Induce T Cell Immunity
- (2014) Alexander Shimabukuro-Vornhagen et al. JOURNAL OF IMMUNOLOGY
- Liver X receptor regulates mouse GM-CSF-derived dendritic cell differentiation in vitro
- (2014) Limei Zhong et al. MOLECULAR IMMUNOLOGY
- Cholesterol Lowering Modulates T Cell Function In Vivo and In Vitro
- (2014) Kuang-Yuh Chyu et al. PLoS One
- Oxysterols are agonist ligands of ROR t and drive Th17 cell differentiation
- (2014) P. Soroosh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling
- (2014) E. S. Gold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
- (2014) A. Reboldi et al. SCIENCE
- The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release
- (2013) Darren Lee Asquith et al. ANNALS OF THE RHEUMATIC DISEASES
- Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells
- (2013) Yonghae Son et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulation of mevalonate metabolism in cancer and immune cells
- (2013) Martin Thurnher et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Enteroviruses Harness the Cellular Endocytic Machinery to Remodel the Host Cell Cholesterol Landscape for Effective Viral Replication
- (2013) Olha Ilnytska et al. Cell Host & Microbe
- IntracellularMycobacterium tuberculosisExploits Host-derived Fatty Acids to Limit Metabolic Stress
- (2013) Wonsik Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils
- (2013) Laura Raccosta et al. JOURNAL OF EXPERIMENTAL MEDICINE
- mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
- (2013) Hu Zeng et al. NATURE
- Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
- (2013) Yoko Kidani et al. NATURE IMMUNOLOGY
- Metabolic targets for cancer therapy
- (2013) Lorenzo Galluzzi et al. NATURE REVIEWS DRUG DISCOVERY
- CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation
- (2013) F. Flores-Borja et al. Science Translational Medicine
- Interleukin-18 and IL-18 Binding Protein
- (2013) Charles A. Dinarello et al. Frontiers in Immunology
- Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses
- (2012) Nathanael J. Spann et al. CELL
- Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses
- (2012) Tangsheng Yi et al. IMMUNITY
- Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol
- (2012) Su-Yang Liu et al. IMMUNITY
- The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response
- (2012) Mathieu Blanc et al. IMMUNITY
- Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering
- (2012) Eszter Molnár et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tumor-promoting Versus Tumor-antagonizing Roles of γδ T Cells in Cancer Immunotherapy
- (2012) Volker Kunzmann et al. JOURNAL OF IMMUNOTHERAPY
- Increased Membrane Cholesterol in Lymphocytes Diverts T-Cells toward an Inflammatory Response
- (2012) Jacqueline Surls et al. PLoS One
- Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease
- (2012) HISATOSHI SUGIURA et al. RESPIROLOGY
- Statins accelerate the onset of collagen type II-induced arthritis in mice
- (2012) Rob J Vandebriel et al. ARTHRITIS RESEARCH & THERAPY
- Lipid paradox in rheumatoid arthritis: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease
- (2011) E. Myasoedova et al. ANNALS OF THE RHEUMATIC DISEASES
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- LXRα Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8
- (2011) Benoit Pourcet et al. CIRCULATION RESEARCH
- Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice
- (2011) Omar M. Khan et al. JOURNAL OF CLINICAL INVESTIGATION
- Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
- (2011) Guoliang Cui et al. JOURNAL OF CLINICAL INVESTIGATION
- Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling
- (2011) M. B. Fessler et al. JOURNAL OF IMMUNOLOGY
- Oxysterols direct B-cell migration through EBI2
- (2011) Changlu Liu et al. NATURE
- Oxysterols direct immune cell migration via EBI2
- (2011) Sébastien Hannedouche et al. NATURE
- Statins Enhance Formation of Phagocyte Extracellular Traps
- (2010) Ohn A. Chow et al. Cell Host & Microbe
- Cholesterol, the central lipid of mammalian cells
- (2010) Frederick R Maxfield et al. CURRENT OPINION IN CELL BIOLOGY
- CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
- (2010) Paul A. Blair et al. IMMUNITY
- Activation of Liver X Receptor Sensitizes Human Dendritic Cells to Inflammatory Stimuli
- (2010) D. Torocsik et al. JOURNAL OF IMMUNOLOGY
- Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
- (2010) Makoto Hirotani et al. JOURNAL OF NEUROIMMUNOLOGY
- Adenosine-Triphosphate-Binding Cassette Transporter-1 Trafficking and Function
- (2010) Martin H. Kang et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Acyl-coenzyme A:cholesterol acyltransferases
- (2009) Ta-Yuan Chang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The LDL Receptor
- (2009) Joseph L. Goldstein et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR
- (2009) Noelia A-Gonzalez et al. IMMUNITY
- Molecular mechanism and function of CD40/CD40L engagement in the immune system
- (2009) Raul Elgueta et al. IMMUNOLOGICAL REVIEWS
- Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
- (2009) Hannelie Korf et al. JOURNAL OF CLINICAL INVESTIGATION
- Liver X Receptors Control IgE Expression in B Cells
- (2009) G. Heine et al. JOURNAL OF IMMUNOLOGY
- Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
- (2009) Ulf Diczfalusy et al. JOURNAL OF LIPID RESEARCH
- Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
- (2009) Eduardo J Villablanca et al. NATURE MEDICINE
- 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
- (2009) D. R. Bauman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response
- (2008) Steven J. Bensinger et al. CELL
- Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance
- (2008) Arun Radhakrishnan et al. Cell Metabolism
- Lipids, lipid modifying agents and cardiovascular risk: a review of the evidence
- (2008) David Preiss et al. CLINICAL ENDOCRINOLOGY
- Th17 cells in human disease
- (2008) Laura A. Tesmer et al. IMMUNOLOGICAL REVIEWS
- Integration of metabolism and inflammation by lipid-activated nuclear receptors
- (2008) Steven J. Bensinger et al. NATURE
- The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
- (2008) Nicolas Manel et al. NATURE IMMUNOLOGY
- Cellular cholesterol trafficking and compartmentalization
- (2008) Elina Ikonen NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mammalian Rho GTPases: new insights into their functions from in vivo studies
- (2008) Sarah J. Heasman et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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