Liver X receptors in lipid signalling and membrane homeostasis

Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis

(2018) Bo Wang et al.   Cell Stem Cell

ER phospholipid composition modulates lipogenesis during feeding and in obesity

(2017) Xin Rong et al.   JOURNAL OF CLINICAL INVESTIGATION

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease

(2017) Courtney Lane-Donovan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils

(2016) Todd G. Kirchgessner et al.   Cell Metabolism

Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion

(2016) Lily Jakulj et al.   Cell Metabolism

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

(2016) Bo Wang et al.   Cell Metabolism

Development of Tetrachlorophthalimides as Liver X Receptor β (LXRβ)-Selective Agonists

(2016) Sayaka Nomura et al.   ChemMedChem

Cholesterol Accumulation in CD11c + Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease

(2016) Ayaka Ito et al.   IMMUNITY

Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer’s Disease

(2016) Shawn J. Stachel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist

(2016) Yajun Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

(2016) Tamer Sallam et al.   NATURE

Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex

(2016) Jing Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LXR Regulation of Brain Cholesterol: From Development to Disease

(2016) Rebecca Courtney et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Deficiency in Lysophosphatidylcholine Acyltransferase 3 Reduces Plasma Levels of Lipids by Reducing Lipid Absorption in Mice

(2015) Zhiqiang Li et al.   GASTROENTEROLOGY

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis

(2015) Jinkuk Choi et al.   Science Translational Medicine

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

(2015) Xin Rong et al.   eLife

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

(2015) Tomomi Hashidate-Yoshida et al.   eLife

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

The LXR–Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice

(2014) Cynthia Hong et al.   Cell Metabolism

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

Liver X Receptor Regulates Arachidonic Acid Distribution and Eicosanoid Release in Human Macrophages

(2013) Minako Ishibashi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

(2013) Simon W. Beaven et al.   Cell Metabolism

IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

(2013) E. Scotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Sterols and oxysterols in immune cell function

(2013) Nathanael J Spann et al.   NATURE IMMUNOLOGY

Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding

(2013) A. Koeberle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Determinants of Statin-Induced Low-Density Lipoprotein Cholesterol Reduction

(2012) Daniel I. Chasman et al.   Circulation-Cardiovascular Genetics

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

(2012) Yoko Kidani et al.   IMMUNOLOGICAL REVIEWS

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

(2012) Yuan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

(2011) Ryan G. Holzer et al.   CELL

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

(2011) L. Zhang et al.   GENES & DEVELOPMENT

The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans

(2011) Daphna Weissglas-Volkov et al.   JOURNAL OF CLINICAL INVESTIGATION

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

(2011) A. C. Calkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter

(2011) E. J. Tarling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-Specific Liver X Receptor Activation Promotes Macrophage Reverse Cholesterol Transport In Vivo

(2010) Tomoyuki Yasuda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Liver X Receptor Signaling Pathways and Atherosclerosis

(2010) Anna C. Calkin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intestinal Specific LXR Activation Stimulates Reverse Cholesterol Transport and Protects from Atherosclerosis

(2010) Giuseppe Lo Sasso et al.   Cell Metabolism

Regulation of LPCAT3 by LXR

(2010) O. Demeure et al.   GENE

The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

(2010) Cynthia Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

(2010) Cynthia Hong et al.   JOURNAL OF LIPID RESEARCH

Identification of Phenylsulfone-Substituted Quinoxaline (WYE-672) as a Tissue Selective Liver X-receptor (LXR) Agonist

(2010) Baihua Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells

(2010) A J C Pommier et al.   ONCOGENE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue activity

(2010) M. Korach-Andre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central nervous system: cholesterol turnover, brain development and neurodegeneration

(2009) John M. Dietschy   BIOLOGICAL CHEMISTRY

Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator

(2009) Hassen Ratni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of Liver X Receptor Regulates Substrate Oxidation in White Adipocytes

(2009) Britta M. Stenson et al.   ENDOCRINOLOGY

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

(2009) S. Ghisletti et al.   GENES & DEVELOPMENT

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

LXR-SREBP-1c-Phospholipid Transfer Protein Axis Controls Very Low Density Lipoprotein (VLDL) Particle Size

(2009) Hiroaki Okazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR-623, a Novel Liver X-Receptor Agonist, in Healthy Participants

(2009) Arie Katz et al.   JOURNAL OF CLINICAL PHARMACOLOGY

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse

(2009) Elaine M. Quinet et al.   JOURNAL OF LIPID RESEARCH

Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice

(2009) Aldo Grefhorst et al.   JOURNAL OF LIPID RESEARCH

Differential SUMOylation of LXRα and LXRβ Mediates Transrepression of STAT1 Inflammatory Signaling in IFN-γ-Stimulated Brain Astrocytes

(2009) Jee Hoon Lee et al.   MOLECULAR CELL

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Effect of Macrophage Overexpression of Murine Liver X Receptor -α ( LXR -α) on Atherosclerosis in LDL-Receptor Deficient Mice

(2008) Daniel Teupser et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

(2008) Steven J. Bensinger et al.   CELL

Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis

(2008) Dennis E Vance   CURRENT OPINION IN LIPIDOLOGY

LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms

(2008) Lars Verschuren et al.   JOURNAL OF LIPID RESEARCH