mTOR signaling, Tregs and immune modulation

Foxp3+ T Cells Inhibit Antitumor Immune Memory Modulated by mTOR Inhibition

(2014) Yanping Wang et al.   CANCER RESEARCH

Regulatory T cells in cancer immunotherapy

(2014) Hiroyoshi Nishikawa et al.   CURRENT OPINION IN IMMUNOLOGY

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Amino Acids Fuel T Cell-Mediated Inflammation

(2014) Maya C. Poffenberger et al.   IMMUNITY

CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells

(2014) F. Guo et al.   JOURNAL OF IMMUNOLOGY

Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells

(2014) T. Hoshii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cell subsets in human cancer: are they regulating for or against tumor progression?

(2013) Theresa L. Whiteside   CANCER IMMUNOLOGY IMMUNOTHERAPY

mTOR and lymphocyte metabolism

(2013) Hu Zeng et al.   CURRENT OPINION IN IMMUNOLOGY

Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment

(2013) Thomas F Gajewski et al.   CURRENT OPINION IN IMMUNOLOGY

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

(2013) Kai Yang et al.   IMMUNITY

Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology

(2013) Michael Kalos et al.   IMMUNITY

Human T follicular helper (Tfh) cells and disease

(2013) Cindy S Ma et al.   IMMUNOLOGY AND CELL BIOLOGY

Promotion and prevention of autoimmune disease by CD8+ T cells

(2013) David M. Gravano et al.   JOURNAL OF AUTOIMMUNITY

Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity

(2013) Alexey Berezhnoy et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

(2013) Geok Choo Sim et al.   JOURNAL OF CLINICAL INVESTIGATION

TSC1 regulates the balance between effector and regulatory T cells

(2013) Yoon Park et al.   JOURNAL OF CLINICAL INVESTIGATION

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Regulatory T cell proliferative potential is impaired in human autoimmune disease

(2013) Fortunata Carbone et al.   NATURE MEDICINE

mTOR and metabolic pathways in T cell quiescence and functional activation

(2013) Kai Yang et al.   SEMINARS IN IMMUNOLOGY

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

(2013) Stephen R Daley et al.   eLife

Molecular Determinants of Regulatory T Cell Development: The Essential Roles of Epigenetic Changes

(2013) Yohko Kitagawa et al.   Frontiers in Immunology

Regulatory T Cells Exhibit Decreased Proliferation but Enhanced Suppression After Pulsing With Sirolimus

(2012) K. Singh et al.   AMERICAN JOURNAL OF TRANSPLANTATION

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

(2012) Keunwook Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leptin-Induced mTOR Activation Defines a Specific Molecular and Transcriptional Signature Controlling CD4+ Effector T Cell Responses

(2012) C. Procaccini et al.   JOURNAL OF IMMUNOLOGY

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

Phenotypic and Functional Properties of Helios+ Regulatory T Cells

(2012) Daniel J. Zabransky et al.   PLoS One

TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice

(2012) Lianjun Zhang et al.   PLoS One

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

Sirolimus Enhances the Magnitude and Quality of Viral-Specific CD8+ T-Cell Responses to Vaccinia Virus Vaccination in Rhesus Macaques

(2011) A. P. Turner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines

(2011) Y Wang et al.   BRITISH JOURNAL OF CANCER

Regulation of T-cell survival and mitochondrial homeostasis by TSC1

(2011) Thomas F. O'Brien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells

(2011) E. Tresoldi et al.   HAEMATOLOGICA

A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8+ T Cell Memory and Tumor Immunity

(2011) Qingsheng Li et al.   IMMUNITY

CD103 is a hallmark of tumor-infiltrating regulatory T cells

(2011) David Anz et al.   INTERNATIONAL JOURNAL OF CANCER

Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells

(2011) R. A. Gottschalk et al.   JOURNAL OF IMMUNOLOGY

The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism

(2011) Nancie J. MacIver et al.   JOURNAL OF IMMUNOLOGY

The Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells

(2011) Q. Wu et al.   JOURNAL OF IMMUNOLOGY

Loss of T Cell CD98 H Chain Specifically Ablates T Cell Clonal Expansion and Protects from Autoimmunity

(2011) J. Cantor et al.   JOURNAL OF IMMUNOLOGY

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells

(2011) Tatiana N. Golovina et al.   PLoS One

Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression

(2011) Karine Serre et al.   PLoS One

Helios Expression Is a Marker of T Cell Activation and Proliferation

(2011) Tatiana Akimova et al.   PLoS One

Suppression of leukemia development caused by PTEN loss

(2011) W. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation

(2011) Kajsa Wing et al.   TRENDS IN IMMUNOLOGY

mTOR Signaling

(2011) M. Laplante et al.   Cold Spring Harbor Perspectives in Biology

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)

(2010) Tyler R Simpson et al.   CURRENT OPINION IN IMMUNOLOGY

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

The role of natural regulatory T cells in infection

(2010) Ana M. Sanchez et al.   IMMUNOLOGIC RESEARCH

Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice

(2010) Xiaohe Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin Modulates the Survival of Autoreactive CD4+ T Cells through the Nutrient/Energy-Sensing Mammalian Target of Rapamycin Signaling Pathway

(2010) M. Galgani et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses

(2010) I. R. Ferrer et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

(2010) Derese Getnet et al.   MOLECULAR IMMUNOLOGY

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

IL-35-mediated induction of a potent regulatory T cell population

(2010) Lauren W Collison et al.   NATURE IMMUNOLOGY

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

(2010) Matthew R Janes et al.   NATURE MEDICINE

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression

(2009) Yonghao Cao et al.   CELL RESEARCH

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

(2009) Peter Tamás et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

(2009) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

(2009) Guangwei Liu et al.   NATURE IMMUNOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

(2009) Yann M Kerdiles et al.   NATURE IMMUNOLOGY

Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs

(2009) K. Bocian et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function

(2008) Alice Mayer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

(2008) Johnthomas Kang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

(2008) Beth Apsel et al.   Nature Chemical Biology

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

(2008) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology