Cholesterol metabolism: At the cross road between cancer cells and immune environment

27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells

(2020) Shweta Dambal et al.   MOLECULAR CANCER RESEARCH

The cellular function of SCAP in metabolic signaling

(2020) Sun Hee Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma

(2020) Dimas Carolina Belisario et al.   Cells

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

(2020) Joanna Kopecka et al.   Cells

Cholesterol metabolism: New functions and therapeutic approaches in cancer

(2020) Huanji Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

(2019) Christopher E. Mahoney et al.   Nature Communications

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

(2019) Javier Garcia-Bermudez et al.   NATURE

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

(2019) Pieter Goossens et al.   Cell Metabolism

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma

(2018) Xiaoping Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABCA1, apoA-I, and BTN3A1: A Legitimate Ménage à Trois in Dendritic Cells

(2018) Chiara Riganti et al.   Frontiers in Immunology

27-hydroxycholesterol decreases cell proliferation in colon cancer cell lines

(2018) Jessica Warns et al.   BIOCHIMIE

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

(2018) Yun Xia et al.   CELL

The Role of Oxysterols in Human Cancer

(2017) Alzbeta Kloudova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

(2017) Amy E. Baek et al.   Nature Communications

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

(2017) Barbara Castella et al.   Nature Communications

Mevalonate metabolism governs cancer immune surveillance

(2017) Georg Gruenbacher et al.   OncoImmunology

Regulatory properties of statins and rho gtpases prenylation inhibitiors to stimulate melanoma immunogenicity and promote anti-melanoma immune response

(2016) Guillaume Sarrabayrouse et al.   INTERNATIONAL JOURNAL OF CANCER

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Control of the innate immune response by the mevalonate pathway

(2016) Murali K Akula et al.   NATURE IMMUNOLOGY

Protein prenylation: unique fats make their mark on biology

(2016) Mei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors

(2016) Joanna Kopecka et al.   Oncotarget

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

Anergic bone marrow Vγ9Vδ2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma

(2015) Barbara Castella et al.   OncoImmunology

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma

(2015) Iris Chiara Salaroglio et al.   Oncotarget

The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils

(2013) Laura Raccosta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

Immune Modulation by Zoledronic Acid in Human Myeloma: An Advantageous Cross-Talk between V 9V 2 T Cells,    CD8+ T Cells, Regulatory T Cells, and Dendritic Cells

(2011) B. Castella et al.   JOURNAL OF IMMUNOLOGY

Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

(2009) Eduardo J Villablanca et al.   NATURE MEDICINE

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

(2008) A. J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA