Regulation of atherosclerotic plaque inflammation

Aspirin-triggered 15-epi-lipoxin A4 signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation

(2015) Marcelo H. Petri et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Discovery of Small Molecule CD40–TRAF6 Inhibitors

(2015) Barbara Zarzycka et al.   Journal of Chemical Information and Modeling

Chemokines in Atherosclerosis

(2014) Alma Zernecke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

(2014) Magnus Bäck et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability

(2014) Marcelo H. Petri et al.   CARDIOVASCULAR RESEARCH

Deficiency of the Sialyltransferase St3Gal4 Reduces Ccl5-Mediated Myeloid Cell Recruitment and Arrest

(2014) Yvonne Döring et al.   CIRCULATION RESEARCH

Biomechanical factors in atherosclerosis: mechanisms and clinical implications

(2014) Brenda R. Kwak et al.   EUROPEAN HEART JOURNAL

Anti-CD40-mediated cancer immunotherapy: an update of recent and ongoing clinical trials

(2014) Sufia Butt Hassan et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Towards non-invasive imaging of vulnerable atherosclerotic plaques by targeting co-stimulatory molecules

(2014) Adrienne Müller et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors

(2014) Sven de Vos et al.   Journal of Hematology & Oncology

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1

(2014) Andreas Schober et al.   NATURE MEDICINE

Programmed Cell Death-1 Deficiency Exacerbates T Cell Activation and Atherogenesis despite Expansion of Regulatory T Cells in Atherosclerosis-Prone Mice

(2014) Clément Cochain et al.   PLoS One

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

(2014) A. Chatzigeorgiou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Docosahexaenoic acid supplementation modifies fatty acid incorporation in tissues and prevents hypoxia induced-atherosclerosis progression in apolipoprotein-E deficient mice

(2014) Laetitia Van Noolen et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Interruption of classic CD40L-CD40 signalling but not of the novel CD40L-Mac-1 interaction limits arterial neointima formation in mice

(2014) Benjamin Rupprecht et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions

(2014) Andreas Doesch et al.   Drug Design Development and Therapy

Pharmacological Inhibition of the Chemokine Receptor, CX3CR1, Reduces Atherosclerosis in Mice

(2013) Lucie Poupel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CXCL12 Promotes the Stabilization of Atherosclerotic Lesions Mediated by Smooth Muscle Progenitor Cells in Apoe -Deficient Mice

(2013) Shamima Akhtar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leukocyte-Specific CCL3 Deficiency Inhibits Atherosclerotic Lesion Development by Affecting Neutrophil Accumulation

(2013) Saskia C.A. de Jager et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating CD40 + and CD86 + B Cell Subsets Demonstrate Opposing Associations With Risk of Stroke

(2013) Polyxeni T. Mantani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phase IA/II, multicentre, open-label study of the CD40 antagonistic monoclonal antibody lucatumumab in adult patients with advanced non-Hodgkin or Hodgkin lymphoma

(2013) Michelle Fanale et al.   BRITISH JOURNAL OF HAEMATOLOGY

Leukotrienes as a molecular link between obstructive sleep apnoea and atherosclerosis

(2013) Françoise Stanke-Labesque et al.   CARDIOVASCULAR RESEARCH

Inflammation and immune system interactions in atherosclerosis

(2013) Bart Legein et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Efficacy of the CCR5 Antagonist Maraviroc in Reducing Early, Ritonavir-Induced Atherogenesis and Advanced Plaque Progression in Mice

(2013) Sabrina Cipriani et al.   CIRCULATION

Activation of CXCR7 Limits Atherosclerosis and Improves Hyperlipidemia by Increasing Cholesterol Uptake in Adipose Tissue

(2013) Xiaofeng Li et al.   CIRCULATION

A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma

(2013) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Lymphocytic tumor necrosis factor receptor superfamily co-stimulatory molecules in the pathogenesis of atherosclerosis

(2013) Esther Smeets et al.   CURRENT OPINION IN LIPIDOLOGY

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

(2013) Oliver Soehnlein et al.   EMBO Molecular Medicine

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans

(2013) Peter Libby et al.   IMMUNITY

T-cell co-stimulation by CD28–CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development

(2013) M.M. Ewing et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Adaptive immunity in atherogenesis: new insights and therapeutic approaches

(2013) Andrew H. Lichtman et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

(2013) Roland Klingenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCL5 limits macrophage foam cell formation in atherosclerosis

(2013) Anthony Rousselle et al.   JOURNAL OF CLINICAL INVESTIGATION

Interruption of the OX40-OX40 Ligand Pathway in LDL Receptor-Deficient Mice Causes Regression of Atherosclerosis

(2013) A. C. Foks et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium bovisBCG killed by extended freeze-drying induces an immunoregulatory profile and protects against atherosclerosis

(2013) O. A. Ovchinnikova et al.   JOURNAL OF INTERNAL MEDICINE

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

(2013)   LANCET

CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice

(2013) Ela Karshovska et al.   THROMBOSIS AND HAEMOSTASIS

Contribution of Platelet CX 3 CR1 to Platelet–Monocyte Complex Formation and Vascular Recruitment During Hyperlipidemia

(2012) Otilia Postea et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interference of the CD30–CD30L Pathway Reduces Atherosclerosis Development

(2012) Amanda C. Foks et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Distribution of macrophage polarization markers in human atherosclerosis

(2012) J. Lauran Stöger et al.   ATHEROSCLEROSIS

A phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma

(2012) William Bensinger et al.   BRITISH JOURNAL OF HAEMATOLOGY

CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE−/− mice

(2012) Kongyang Ma et al.   CARDIOVASCULAR RESEARCH

Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice

(2012) Wuzhou Wan et al.   CARDIOVASCULAR RESEARCH

Conditional Targeting of Tumor Necrosis Factor Receptor–Associated Factor 6 Reveals Opposing Functions of Toll-Like Receptor Signaling in Endothelial and Myeloid Cells in a Mouse Model of Atherosclerosis

(2012) Apostolos Polykratis et al.   CIRCULATION

Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice

(2012) Yvonne Döring et al.   CIRCULATION RESEARCH

Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis

(2012) Dirk Lievens et al.   EUROPEAN HEART JOURNAL

Nationwide cohort study of the leukotriene receptor antagonist montelukast and incident or recurrent cardiovascular disease

(2012) Erik Ingelsson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Treatment with Evasin-3 Reduces Atherosclerotic Vulnerability for Ischemic Stroke, but Not Brain Injury in Mice

(2012) Jean-Christophe Copin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia

(2012) John C. Byrd et al.   LEUKEMIA & LYMPHOMA

Impact of Macrophage Inflammatory Protein-1α Deficiency on Atherosclerotic Lesion Formation, Hepatic Steatosis, and Adipose Tissue Expansion

(2012) Arion Kennedy et al.   PLoS One

Regulation of Atherogenesis by Chemokine Receptor CCR6

(2012) Wuzhou Wan et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Effect of CC Chemokine Receptor 2 CCR2 Blockade on Serum C-Reactive Protein in Individuals at Atherosclerotic Risk and With a Single Nucleotide Polymorphism of the Monocyte Chemoattractant Protein-1 Promoter Region

(2011) Jim Gilbert et al.   AMERICAN JOURNAL OF CARDIOLOGY

Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation

(2011) De-xiu Bu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Crucial Role of CD40 Signaling in Vascular Wall Cells in Neointimal Formation and Vascular Remodeling After Vascular Interventions

(2011) Zifang Song et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Lipoprotein-Derived Lysophosphatidic Acid Promotes Atherosclerosis by Releasing CXCL1 from the Endothelium

(2011) Zhe Zhou et al.   Cell Metabolism

Upregulation of the 5-Lipoxygenase Pathway in Human Aortic Valves Correlates With Severity of Stenosis and Leads to Leukotriene-Induced Effects on Valvular Myofibroblasts

(2011) Edit Nagy et al.   CIRCULATION

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

Genetic Deletion of Chemokine Receptor Ccr6 Decreases Atherogenesis in ApoE -Deficient Mice

(2011) Wuzhou Wan et al.   CIRCULATION RESEARCH

B-Cell Aortic Homing and Atheroprotection Depend on Id3

(2011) Amanda C. Doran et al.   CIRCULATION RESEARCH

The Role of Matrix Metalloproteinases in Atherothrombosis

(2011) Daniel F. J. Ketelhuth et al.   Current Atherosclerosis Reports

Intraplaque haemorrhages as the trigger of plaque vulnerability

(2011) J.-B. Michel et al.   EUROPEAN HEART JOURNAL

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

(2011) Christian Weber et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

(2011) Stephane Potteaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Belatacept

(2011) Flavio Vincenti et al.   NATURE REVIEWS DRUG DISCOVERY

Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis

(2011) P. Fogelstrand et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

CD40 Is Essential in the Upregulation of TRAF Proteins and NF-KappaB-Dependent Proinflammatory Gene Expression after Arterial Injury

(2011) Zifang Song et al.   PLoS One

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Aspirin-Triggered Lipoxin and Resolvin E1 Modulate Vascular Smooth Muscle Phenotype and Correlate with Peripheral Atherosclerosis

(2010) Karen J. Ho et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis

(2010) Olof Rådmark et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

(2010) D. Lievens et al.   BLOOD

CD137 (4–1BB) Deficiency Reduces Atherosclerosis in Hyperlipidemic Mice

(2010) Hyung Jun Jeon et al.   CIRCULATION

Tumor Necrosis Factor Receptor–Associated Factor 1 (TRAF1) Deficiency Attenuates Atherosclerosis in Mice by Impairing Monocyte Recruitment to the Vessel Wall

(2010) Anna Missiou et al.   CIRCULATION

Chemokine Receptor 7 Knockout Attenuates Atherosclerotic Plaque Development

(2010) Maren Luchtefeld et al.   CIRCULATION

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

(2010) Alexandra Kadl et al.   CIRCULATION RESEARCH

TRAF5 Deficiency Accelerates Atherogenesis in Mice by Increasing Inflammatory Cell Recruitment and Foam Cell Formation

(2010) Anna Missiou et al.   CIRCULATION RESEARCH

Treatment With 5-Lipoxygenase Inhibitor VIA-2291 (Atreleuton) in Patients With Recent Acute Coronary Syndrome

(2010) Jean-Claude Tardif et al.   Circulation-Cardiovascular Imaging

FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis

(2010) Paola Maderna et al.   FASEB JOURNAL

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

(2010) Esther Lutgens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B cell depletion reduces the development of atherosclerosis in mice

(2010) Hafid Ait-Oufella et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor Necrosis Factor Receptor Associated Factor 6 Is Not Required for Atherogenesis in Mice and Does Not Associate with Atherosclerosis in Humans

(2010) Peter Stachon et al.   PLoS One

The role of CD154 in haematopoietic development

(2010) Tom Seijkens et al.   THROMBOSIS AND HAEMOSTASIS

Leukotriene Receptor Antagonism and the Prevention of Extracellular Matrix Degradation During Atherosclerosis and In-Stent Stenosis

(2009) Hanna Hlawaty et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mediators of neutrophil recruitment in human abdominal aortic aneurysms

(2009) Xavier Houard et al.   CARDIOVASCULAR RESEARCH

CXCL4 Downregulates the Atheroprotective Hemoglobin Receptor CD163 in Human Macrophages

(2009) Christian A. Gleissner et al.   CIRCULATION RESEARCH

Inhibitors of the 5-Lipoxygenase Pathway in Atherosclerosis

(2009) Magnus Back   CURRENT PHARMACEUTICAL DESIGN

Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus

(2009) Xavier Houard et al.   FASEB JOURNAL

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists

(2009) Denis Sohy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

CD40 and autoimmunity: The dark side of a great activator

(2009) Anna L. Peters et al.   SEMINARS IN IMMUNOLOGY

The immunobiology of CD154–CD40–TRAF interactions in atherosclerosis

(2009) David Engel et al.   SEMINARS IN IMMUNOLOGY

Heterogeneity of Human Macrophages in Culture and in Atherosclerotic Plaques

(2008) Stephen W. Waldo et al.   AMERICAN JOURNAL OF PATHOLOGY

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

(2008) L. Landsman et al.   BLOOD

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling

(2008) M. M. P. C. Donners et al.   BLOOD

Leukotriene Signaling in Atherosclerosis and Ischemia

(2008) Magnus Bäck   CARDIOVASCULAR DRUGS AND THERAPY

Multidrug Resistance Protein-1 Affects Oxidative Stress, Endothelial Dysfunction, and Atherogenesis via Leukotriene C 4 Export

(2008) Cornelius F.H. Mueller et al.   CIRCULATION

CD137 Is Expressed in Human Atherosclerosis and Promotes Development of Plaque Inflammation in Hypercholesterolemic Mice

(2008) Peder S. Olofsson et al.   CIRCULATION

Anti-oxLDL antibody isotype levels, as potential markers for progressive atherosclerosis in APOE−/−and APOE−/−CD40L−/−mice

(2008) M. L. F. Smook et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammatory signaling through leukotriene receptors in atherosclerosis

(2008) Magnus Bäck   Current Atherosclerosis Reports

CD40 Ligand+ Microparticles From Human Atherosclerotic Plaques Stimulate Endothelial Proliferation and Angiogenesis

(2008) Aurélie S. Leroyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

(2007) Alma Zernecke et al.   CIRCULATION RESEARCH