LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

(2015) Xin Rong et al.   eLife

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

Laurdan Fluorescence Lifetime Discriminates Cholesterol Content from Changes in Fluidity in Living Cell Membranes

(2013) Ottavia Golfetto et al.   BIOPHYSICAL JOURNAL

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

(2013) Marit Westerterp et al.   CIRCULATION RESEARCH

Characterization of Cholesterol Homeostasis in Telomerase-immortalized Tangier Disease Fibroblasts Reveals Marked Phenotype Variability

(2013) Frank Kannenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TLE3 Is a Dual-Function Transcriptional Coregulator of Adipogenesis

(2011) Claudio J. Villanueva et al.   Cell Metabolism

Eliminating SF-1 (NR5A1) Sumoylation In Vivo Results in Ectopic Hedgehog Signaling and Disruption of Endocrine Development

(2011) Florence Y. Lee et al.   DEVELOPMENTAL CELL

Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling

(2011) M. B. Fessler et al.   JOURNAL OF IMMUNOLOGY

Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding

(2011) Trevor Siggers et al.   NATURE IMMUNOLOGY

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXR  in the hepatic acute phase response

(2010) N. Venteclef et al.   GENES & DEVELOPMENT

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol

(2010) Xuewei Zhu et al.   JOURNAL OF LIPID RESEARCH

Differential SUMOylation of LXRα and LXRβ Mediates Transrepression of STAT1 Inflammatory Signaling in IFN-γ-Stimulated Brain Astrocytes

(2009) Jee Hoon Lee et al.   MOLECULAR CELL

Increased Cellular Free Cholesterol in Macrophage-specificAbca1Knock-out Mice Enhances Pro-inflammatory Response of Macrophages

(2008) Xuewei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased Recognition of SUMO-Sensitive Target Genes following Modification of SF-1 (NR5A1)

(2008) L. A. Campbell et al.   MOLECULAR AND CELLULAR BIOLOGY