Impact of Cholesterol Metabolism in Immune Cell Function and Atherosclerosis

Neutrophils as regulators of cardiovascular inflammation

(2020) Carlos Silvestre-Roig et al.   Nature Reviews Cardiology

Regulation of intestinal lipid metabolism: current concepts and relevance to disease

(2020) Chih-Wei Ko et al.   Nature Reviews Gastroenterology & Hepatology

Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway

(2020) Guodong Tie et al.   Scientific Reports

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

(2019) Qilin Gu et al.   SCIENCE

Immune-Inflammatory Responses in Atherosclerosis: The Role of Myeloid Cells

(2019) Dimitry A. Chistiakov et al.   Journal of Clinical Medicine

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis and Atherogenesis

(2018) Marit Westerterp et al.   CIRCULATION

Hypercholesterolemia induces T cell expansion in humanized immune mice

(2018) Jonathan D. Proto et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of macrophage immunometabolism in atherosclerosis

(2018) Graeme J. Koelwyn et al.   NATURE IMMUNOLOGY

Cholesterol Transport Revisited: A New Turbo Mechanism to Drive Cholesterol Excretion

(2018) Jan Freark de Boer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Molecular Pathways Underlying Cholesterol Homeostasis

(2018) Milessa Silva Afonso et al.   Nutrients

Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis

(2018) Guanmei Wen et al.   Journal of the American Heart Association

LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux

(2018) David G. Thomas et al.   Cell Reports

Monocyte-Macrophages and T Cells in Atherosclerosis

(2017) Ira Tabas et al.   IMMUNITY

Monocyte and macrophage immunometabolism in atherosclerosis

(2017) Laszlo Groh et al.   Seminars in Immunopathology

Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function

(2017) George A. Robinson et al.   Frontiers in Immunology

Cholesterol Metabolism in T Cells

(2017) Andreas Bietz et al.   Frontiers in Immunology

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Atherosclerosis — do we know enough already to prevent it?

(2016) Chandrakala Aluganti Narasimhulu et al.   CURRENT OPINION IN PHARMACOLOGY

Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

(2016) Deepika Awasthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis

(2016) Hsin-Yuan Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol

(2016) Feng Wang et al.   NATURE IMMUNOLOGY

Lymphocytes in Atherosclerosis

(2015) C. C. Hedrick   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Treg/Th17 balance in stable CAD patients with different stages of coronary atherosclerosis

(2015) Alexandra V. Potekhina et al.   ATHEROSCLEROSIS

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

The Relation Between Atherosclerosis and the Neutrophil–Lymphocyte Ratio

(2015) Sevket Balta et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism

(2015) Michael B. Fessler   CURRENT ALLERGY AND ASTHMA REPORTS

7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils

(2015) Gonzalo Alba et al.   EUROPEAN JOURNAL OF NUTRITION

Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists

(2015) Xiao Hu et al.   Nature Chemical Biology

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Regulation of High-Density Lipoprotein on Hematopoietic Stem/Progenitor Cells in Atherosclerosis Requires Scavenger Receptor Type BI Expression

(2014) Mingming Gao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

(2014) Jing Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis

(2014) Sergio Martínez-Hervás et al.   CARDIOVASCULAR RESEARCH

Nuclear bile acid signaling through the farnesoid X receptor

(2014) Claire Mazuy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

(2014) N. Zelcer et al.   MOLECULAR AND CELLULAR BIOLOGY

Cholesterol Lowering Modulates T Cell Function In Vivo and In Vitro

(2014) Kuang-Yuh Chyu et al.   PLoS One

Oxysterols are agonist ligands of ROR t and drive Th17 cell differentiation

(2014) P. Soroosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The UPS and downs of cholesterol homeostasis

(2014) Laura J. Sharpe et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: Studies in mice and FH children

(2013) Sonia Tolani et al.   ATHEROSCLEROSIS

ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis

(2013) Houpu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

Low Levels of Circulating CD4+FoxP3+ T Cells Are Associated With an Increased Risk for Development of Myocardial Infarction But Not for Stroke

(2012) Maria Wigren et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Hematopoietic Stem and Progenitor Cell Mobilization by Cholesterol Efflux Pathways

(2012) Marit Westerterp et al.   Cell Stem Cell

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(2012) Xiao Meng et al.   MOLECULAR MEDICINE

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased Membrane Cholesterol in Lymphocytes Diverts T-Cells toward an Inflammatory Response

(2012) Jacqueline Surls et al.   PLoS One

Hematopoietic Stem/Progenitor Cell Proliferation and Differentiation Is Differentially Regulated by High-Density and Low-Density Lipoproteins in Mice

(2012) Yingmei Feng et al.   PLoS One

Hypercholesterolemia links hematopoiesis with atherosclerosis

(2012) Oliver Soehnlein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of cholesterol homeostasis

(2011) Leigh Goedeke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

(2011) Andrew J. Murphy et al.   JOURNAL OF CLINICAL INVESTIGATION

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

(2011) Cynthia Hong et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloperoxidase modulation by LDL apheresis in Familial Hypercholesterolemia

(2011) Mariarita Puntoni et al.   Lipids in Health and Disease

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

(2010) L. Yvan-Charvet et al.   SCIENCE

Apolipoprotein A-I and Its Role in Lymphocyte Cholesterol Homeostasis and Autoimmunity

(2009) Ashley J. Wilhelm et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Functional Role of CD11c + Monocytes in Atherogenesis Associated With Hypercholesterolemia

(2009) Huaizhu Wu et al.   CIRCULATION

ATP-Binding Cassette Transporter G1 Negatively Regulates Thymocyte and Peripheral Lymphocyte Proliferation

(2009) Allison J. Armstrong et al.   JOURNAL OF IMMUNOLOGY

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

(2008) Steven J. Bensinger et al.   CELL

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

(2008) Laurent Yvan-Charvet et al.   CIRCULATION

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Primed polymorphonuclear leukocytes constitute a possible link between inflammation and oxidative stress in hyperlipidemic patients

(2007) Rafi Mazor et al.   ATHEROSCLEROSIS