Role of CCL2/CCR2 axis in the immunopathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches

An overview of autoantibodies in rheumatoid arthritis

(2020) Myrthe A.M. van Delft et al.   JOURNAL OF AUTOIMMUNITY

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

(2020) Hui Yang et al.   Molecular Cancer

Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis

(2020) Qinghua Fang et al.   MEDIATORS OF INFLAMMATION

Role of autophagy in the pathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches

(2020) Jafar Karami et al.   LIFE SCIENCES

The genetics of rheumatoid arthritis

(2020) Laura E Dedmon   RHEUMATOLOGY

Increased monocyte chemoattractant protein-1 and nitrotyrosine are associated with increased body weight in patients with rheumatoid arthritis after etanercept therapy

(2020) Hsien-Hao Huang et al.   NEUROPEPTIDES

A systematic review and meta-analysis of infection risk with small molecule JAK inhibitors in rheumatoid arthritis

(2019) Katie Bechman et al.   RHEUMATOLOGY

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2

(2018) Saseong Lee et al.   JOURNAL OF IMMUNOLOGY

Clinical management of seronegative and seropositive rheumatoid arthritis: A comparative study

(2018) Sang-Tae Choi et al.   PLoS One

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

(2018) Matteo Massara et al.   Nature Communications

Theeffect of caveolin-1 knockdown on interleukin-1β-induced chemokine (C-C motif) ligand 2 expression in synovial fluid-derived fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2018) Dorota Trzybulska et al.   Advances in Clinical and Experimental Medicine

Chemokine-Induced Macrophage Polarization in Inflammatory Conditions

(2018) Pieter Ruytinx et al.   Frontiers in Immunology

Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis

(2018) Amit Kumar Rana et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diagnosis and Management of Rheumatoid Arthritis

(2018) Daniel Aletaha et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immunopathogenesis of Rheumatoid Arthritis

(2017) Gary S. Firestein et al.   IMMUNITY

Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification

(2017) Yi-Ching Lin et al.   MOLECULAR IMMUNOLOGY

Role of the C-C chemokine receptor-2 in a murine model of injury-induced osteoarthritis

(2017) L. Longobardi et al.   OSTEOARTHRITIS AND CARTILAGE

Elevated ACKR2 expression is a common feature of inflammatory arthropathies

(2017) Helen M. Baldwin et al.   RHEUMATOLOGY

CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone

(2017) Jawed Akhtar Siddiqui et al.   Frontiers in Endocrinology

A brief look at the role of monocyte chemoattractant protein-1 (CCL2) in the pathophysiology of psoriasis

(2017) Shadi Behfar et al.   CYTOKINE

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

(2016) Harini Raghu et al.   ANNALS OF THE RHEUMATIC DISEASES

Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis

(2016) Satish Kumar Devarapu et al.   CLINICAL IMMUNOLOGY

The −2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene (MCP-1) is associated with an increased risk of rheumatoid arthritis in Argentine patients

(2016) Emilia Saint Martin et al.   CLINICAL RHEUMATOLOGY

Overview and potential unifying themes of the atypical chemokine receptor family

(2016) Alessandro Vacchini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis

(2016) Anca I. Catrina et al.   Nature Reviews Rheumatology

Macrophage heterogeneity in the context of rheumatoid arthritis

(2016) Irina A. Udalova et al.   Nature Reviews Rheumatology

Resveratrol lowers synovial hyperplasia, inflammatory markers and oxidative damage in an acute antigen-induced arthritis model

(2016) Romina R. Riveiro-Naveira et al.   RHEUMATOLOGY

Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response

(2016) Raffaella Bonecchi et al.   Frontiers in Immunology

Blockage of TNF-α by Infliximab Reduces CCL2 and CCR2 Levels in Patients With Rheumatoid Arthritis

(2016) Liping Xia et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis

(2015) Kyoung-Woon Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis

(2015) Lin Zhang et al.   YONSEI MEDICAL JOURNAL

The Duffy Antigen Receptor for Chemokines DARC/ACKR1

(2015) Richard Horuk   Frontiers in Immunology

The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density

(2014) K. M. Lee et al.   EMBO JOURNAL

New nomenclature for atypical chemokine receptors

(2014) Françoise Bachelerie et al.   NATURE IMMUNOLOGY

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

The biochemistry and biology of the atypical chemokine receptors

(2012) G.J. Graham et al.   IMMUNOLOGY LETTERS

Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis

(2012) Liat Izhak et al.   PLoS One

Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid arthritis and osteoarthritis

(2011) Kristina Eisinger et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Low-level laser irradiation treatment reduces CCL2 expression in rat rheumatoid synovia via a chemokine signaling pathway

(2011) Lin Zhang et al.   LASERS IN MEDICAL SCIENCE

Pathogenic role of CXCR7 in rheumatoid arthritis

(2010) Kaori Watanabe et al.   ARTHRITIS AND RHEUMATISM

MCP-1: Chemoattractant with a role beyond immunity: A review

(2010) Amita Yadav et al.   CLINICA CHIMICA ACTA

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Quantitative analysis of the secretion of the MCP family of chemokines by muscle cells

(2010) Jeanette Henningsen et al.   Molecular BioSystems

Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2

(2009) M.A. García Lopez et al.   CELLULAR SIGNALLING

CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis

(2009) Jian Zhang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CCR2 promotes hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   HEPATOLOGY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

(2009) Peter C. Taylor et al.   Nature Reviews Rheumatology

The Immunopathogenesis of Rheumatoid Arthritis

(2008) John B. Imboden   Annual Review of Pathology-Mechanisms of Disease

Investigational C-C chemokine receptor 2 antagonists for the treatment of autoimmune diseases

(2008) Alicja Kalinowska et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS